Abstract: The message server system receives a data message transferred by a sending communication system for delivery to a receiving communication system. The data message has a first messaging format with disposition notification codes. The messaging server system converts the data message from the first messaging format to a second messaging format and transfers the data message for delivery to a receiving communication system over a particular communication network. The messaging server system processes the disposition notification codes and responsively transfers a disposition notification for delivery to the sending communication system, indicating that the data message was converted from the first messaging format into the second messaging format, and was transferred over the particular communication network for delivery to the receiving communication system.

Abstract: Compositions comprising peptides that are capable of binding a metal are disclosed. Such compositions can be used for binding metal in a variety of contexts and environments. In various embodiments, peptides are used for antioxidant activity, anti-inflammatory activity, anti-pain therapy, as chemical reagents, and/or as superoxide dismutase mimics.

Abstract: Compositions comprising peptides that are capable of binding a metal in a square planar orientation, a square pyramidal orientation, or both, are disclosed. Such compositions can be used for binding and releasing a metal in a variety of contexts and environments, such as the treatment of cancer.

Abstract: Compositions comprising peptides that are capable of binding a metal are disclosed. Such compositions can be used for binding metal in a variety of contexts and environments. In various embodiments, peptides are used for antioxidant activity, anti-inflammatory activity, anti-pain therapy, as chemical reagents, and/or as superoxide dismutase mimics.

Abstract: Compositions comprising certain tripeptides which are capable of binding a metal in a square planar orientation, a square pyramidal orientation, or both, are disclosed in processes for modulating tagged peptides or proteins. Such compositions and processes may be used for site-specific chiral inversion of amino acids, site-specific peptide cleavage, and protein purification, among other uses.

Abstract: The present invention provides crystal forms of (2-amino-4,5,6,7-tetrahydrobenzo[b]thiophen-3-yl)(4-chlorophenyl)methanone of the formula processes for the production of such crystal forms; pharmaceutical compositions comprising such crystal forms; and methods of treating diseases or conditions modulated by the adenosine A1 receptor, in particular neuropathic pain, in a mammal in need thereof, by employing such crystal forms, or pharmaceutical compositions comprising such.

Abstract: An system and method for monitoring and evaluating solid and semi-solid materials. In an embodiment adapted for pharmaceutical manufacturing, a rotating platter is provided which contains a plurality of chutes. Manufactured items from an earlier section of the manufacturing process are deposited upon the rotating platter, and are separated for analysis by the plurality of chutes. Mounted near the edge radius of the platter is a Raman probe, which focuses photons from a laser onto each of the manufactured items. The manufactured items radiate photons according to Raman scattering principles, which are collected by the Raman probe and analyzed by a computer against a template file. The computer operates upon the chutes to sort and release the manufactured items according to a criteria. Thus, an in-process monitoring and evaluation system may be utilized to inspect and sort manufactured items in real time.

Abstract: A method for carrying out sequential reactions, e.g., sequential biochemical reactions, and a rotary thermocycling apparatus especially adapted for conducting such reactions, for example, polymerase chain reactions, are disclosed. The apparatus comprises a plurality of stations, e.g., four stations, for receiving biochemical samples in flat-bottomed containers. Heating means are provided to independently control the temperature of each station, transport means are provided to move the containers from one station to another in a predetermined sequence, and at least one station has a spray unit to spray liquid reagents into a container at that station. The method includes sequentially cycling a sample through predetermined temperature changes and spraying the sample with at least one reagent.

Abstract: A method for carrying out sequential reactions, e.g., sequential biochemical reactions, and a rotary thermocycling apparatus especially adapted for conducting such reactions, for example, polymerase chain reactions, are disclosed. The apparatus comprises a plurality of stations, e.g., four stations, for receiving biochemical samples in flat-bottomed containers. Heating means are provided to independently control the temperature of each station, transport means are provided to move the containers from one station to another in a predetermined sequence, and at least one station has a spray unit to spray liquid reagents into a container at that station. The method includes sequentially cycling a sample through predetermined temperature changes and spraying the sample with at least one reagent.

Abstract: A rotary thermocycling apparatus, especially for biochemical reactions. The apparatus comprises a plurality of and especially at least four stations for receiving biochemical samples in a flat-bottomed container. Each station has a flat heated plate on which the container is placed and means to independently control the heated plate at a pre-determined temperature.