Patents by Inventor George Lee Peabody, V

George Lee Peabody, V has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • EFFICIENT PRODUCTION OF CIS, CIS-MUCONIC ACID FROM MIXED SUBSTRATES OF GLUCOSE, D-XYLOSE AND L-ARABINOSE
    Publication number: 20240026393
    Abstract: Muconic acid is a molecule that can be converted into direct replacement chemicals for incumbent petrochemicals and performance-advantaged bioproducts. Disclosed herein are Pseudomonas putida KT2440 that are engineered to convert glucose and xylose, the primary carbohydrates in lignocellulosic hydrolysates, to muconic acid using a model-guided strategy to maximize the theoretical yield. Using adaptive laboratory evolution (ALE) and metabolic engineering in a strain engineered to express the D-xylose isomerase pathway, we demonstrated that mutations in the heterologous D-xylose:H+ symporter (XylE), increased expression of a major facilitator superfamily transporter (PP_2569), and overexpression of aroB encoding the native 3-dehydroquinate synthase, enable efficient muconic acid production from glucose and xylose simultaneously. Using the rationally engineered strain, we produced 33.7 g/L muconate at 0.18 g/L/h and a 46% molar yield (92% of the maximum theoretical yield).
    Type: Application
    Filed: March 20, 2023
    Publication date: January 25, 2024
    Inventors: Chen LING, Christopher W. JOHNSON, Gregg Tyler BECKHAM, George Lee PEABODY, V, Adam Michael GUSS
  • Engineered microorganisms for the production of intermediates and final products
    Patent number: 11518975
    Abstract: The present disclosure relates to a non-naturally occurring microorganism that includes an endogenous genetic deletion that eliminates the expression of at least a pyruvate kinase, where the genetically modified prokaryotic microorganism is capable of producing 3-deoxy-D-arabino-heptulosonate-7-phosphate.
    Type: Grant
    Filed: April 30, 2019
    Date of Patent: December 6, 2022
    Assignees: Alliance for Sustainable Energy, LLC, UT-Battelle, LLC, TRIAD National Security, LLC
    Inventors: Christopher W. Johnson, Peter Corbin St. John, Gregg Tyler Beckham, Joshua Ryan Elmore, Adam Michael Guss, Davinia Salvachua Rodriguez, Gayle Joann Bentley, George Lee Peabody, V, Taraka Dale, Ramesh K. Jha, Niju Narayanan
  • ENGINEERED MICROORGANISMS FOR THE PRODUCTION OF INTERMEDIATES AND FINAL PRODUCTS
    Publication number: 20190367865
    Abstract: The present disclosure relates to a non-naturally occurring microorganism that includes an endogenous genetic deletion that eliminates the expression of at least a pyruvate kinase, where the genetically modified prokaryotic microorganism is capable of producing 3-deoxy-D-arabino-heptulosonate-7-phosphate.
    Type: Application
    Filed: April 30, 2019
    Publication date: December 5, 2019
    Inventors: Christopher W. JOHNSON, Peter Corbin ST. JOHN, Gregg Tyler BECKHAM, Joshua Ryan ELMORE, Adam Michael GUSS, Davinia Salvachua RODRIGUEZ, Gayle Joann BENTLEY, George Lee PEABODY V
  • Method of making non-hollow, non-fragmented spherical metal or metal alloy particles
    Patent number: 8888889
    Abstract: The invention is directed to systems and methods for making non-hollow, non-fragmented spherical metal or metal alloy particles using diffusion dryers.
    Type: Grant
    Filed: June 1, 2011
    Date of Patent: November 18, 2014
    Assignees: E I du Pont de Nemours and Company, University of Maryland
    Inventors: Howard David Glicksman, Sheryl Ehrman, Alex Langrock, George Lee Peabody, V, Kai Zhong
  • METHOD OF MAKING NON-HOLLOW, NON-FRAGMENTED SPHERICAL METAL OR METAL ALLOY PARTICLES
    Publication number: 20110293939
    Abstract: The invention is directed to making non-hollow, non-fragmented spherical metal or metal alloy particles.
    Type: Application
    Filed: June 1, 2011
    Publication date: December 1, 2011
    Applicant: E.I.DU PONT DE NEMOURS AND COMPANY UNIVERSITY OF MARYLAND
    Inventors: Howard David Glicksman, Sheryl Ehrman, Alex Langrock, George Lee Peabody, V, Kai Zhong