Abstract: Child safety seat (1) for a vehicle (30) comprising a frame (2) shaped so as to accommodate a child (40) in a child area (3), the frame (2) comprising a sitting portion (2A), a backrest portion (2B) and side portions (2C); at least one impact absorbing assembly (4) connected to the frame (2) and comprising: a deformable polymeric layer (5); at least one honeycomb cellular insert (6) associated with the deformable polymeric layer (5). The at least one honeycomb cellular insert (6) comprises a plurality of open cells (7) having longitudinal axes (L) extending out of an inner/outer surface of the frame (2), said cells (7) being configured to absorb energy by plastic deformation in response to a longitudinal compressive load applied to said cells (7); and the deformable polymeric layer (5) is shaped so as to contain the at least one honeycomb cellular insert (6).

Abstract: Headrest (1) for a racing vehicle (10) comprising a cockpit (11) wherein a driver (20) wearing a helmet (30) can sit, comprising a flexible casing (2) configured to be anchored to a vehicle body (12) and at least one energy-absorbing member (3) comprising at least one honeycomb cellular structure (9) arranged inside said casing (2). The energy-absorbing member (3) further comprising a foam pad (8) shaped so as to hold the at least one honeycomb cellular structure (9).

Abstract: Protective padding (1) for a bar (10) of a rollcage (100) of a vehicle (200) comprising a honeycomb cellular structure (2), a base sheet layer (4), an outer sheet layer (11), and connecting means (3) configured to connect the honeycomb cellular structure (2) to said bar (10); wherein said honeycomb cellular structure (2) comprises a plurality of interconnected open cells (8) having longitudinal axes (L) arranged so that, when the honeycomb cellular structure (2) is connected to the bar (10), part of said longitudinal axes (L) are oriented outwardly with respect to the bar (10) and towards the interior of the rollcage (100); said open cells (8) being configured to absorb energy by plastic deformation in response to a compressive load compressing the honeycomb cellular structure (2) against the bar (10); wherein the base sheet layer (4) is attached to a base face (15) of the honeycomb cellular structure (2) facing the outer surface (13) of the bar (10) and the outer sheet layer (11) is attached to a top face (1

Abstract: Headrest (1) for a racing vehicle (10) comprising a cockpit (11) wherein a driver (20) wearing a helmet (30) can sit, comprising a flexible casing (2) configured to be anchored to a vehicle body (12) and at least one energy-absorbing member (3) comprising at least one honeycomb cellular structure (9) arranged inside said casing (2). The energy-absorbing member (3) further comprising a foam pad (8) shaped so as to hold the at least one honeycomb cellular structure (9).

Abstract: Body-protector (1,1?) comprising: a wearable article (2,2?); a shock-absorbing pad (3) anchored to the wearable article (2,2?); wherein the shock-absorbing pad (3) comprises a first member (4) configured to absorb shock energy by an irreversible plastic deformation and a second member (5) configured to absorb shock energy by a reversible elastic deformation and wherein the first member (4) is embedded in the second member (5); wherein the first member (4) comprises a plurality of cells (6) interconnected each other via their sidewalls (7) to form a pliable sheet (8) configured to absorb energy through irreversible deformation of said sidewalls (7) or said interconnections in response to a compressive load applied to said sheet (8). Said wearable article (2) being a glove (2?) wherein said shock-absorbing pad (3) is anchored to a back of the glove (2?).

Abstract: Thermoforming apparatus (1) for thermoforming an article (2), preferably a permeable article (2?), comprising: an elastic membrane (3,3?); a mould (4,4?); a hot air source (5) configured to blow a hot airflow (6) towards a zone (7) of the apparatus (1) configured to receive the article (2,2?) to be thermoformed; an actuation system (8) configured to move the mould (4,4?) towards the membrane (3,3?) or vice versa to compress the heated article (2,2?) between the membrane (3,3?) and the mould (4) such that an elastic force of the membrane (3,3?) on the article (2,2?) forces the article (2,2?) to assume the shape of the mould (4).2. Thermoforming apparatus (1) according to claim 1, wherein the mould (4?) and/or membrane (3?) are perforated so to permit a transit of the hot airflow (6) from the hot air source (5) to said zone (7).

Abstract: Body-protector (1,1?) comprising: a wearable article (2,2?); a shock-absorbing pad (3) anchored to the wearable article (2,2?); wherein the shock-absorbing pad (3) comprises a first member (4) configured to absorb shock energy by an irreversible plastic deformation and a second member (5) configured to absorb shock energy by a reversible elastic deformation and wherein the first member (4) is embedded in the second member (5); wherein the first member (4) comprises a plurality of cells (6) interconnected each other via their sidewalls (7) to form a pliable sheet (8) configured to absorb energy through irreversible deformation of said sidewalls (7) or said interconnections in response to a compressive load applied to said sheet (8). Said wearable article (2) being a glove (2?) wherein said shock-absorbing pad (3) is anchored to a back of the glove (2?).

Abstract: Protective shell (10) anchorable to a portable mobile device (20) comprising a honeycomb cellular structure (1) enclosed in a body (2) at least in part made of an elastic polymer, the body (2) comprising a back portion (9) configured to cover at least in part a backside (11) of the mobile device (20) and a side portion (12) configured to cover and fit with a sidewall (13) of the mobile device (20) so to anchor the body (2) to the mobile device (20); wherein said honeycomb cellular structure (1) comprises a plurality of open cells (3) connected each other via their sidewalls (14) to form at least a flexible sheet (15) configured to absorb energy through a deformation of said sidewalls (12) in response to a compressive load applied to said sheet (15); and wherein at least a part of the body (2) made of the elastic polymer fully encapsulates and permeates the open cells (3) of said honeycomb cellular structure (1).

Abstract: Helmet (1) comprising a first protective collapsible portion (2), a second protective collapsible portion (4), and at least one energy absorbing pad (3) permeable to air arranged between said first and second protective collapsible portions (2,4), wherein the first collapsible portion (2) and the second collapsible portion (4) are coupled to each other through one or more mechanical couplings (11-16).

Abstract: The application discloses a flexible strap for retaining protective eyewear on a wearer's head. The strap includes an energy absorbing material which is configured to deform to absorb kinetic energy on impact and which is held in contact with a first outer layer. A method of manufacture of the strap is also disclosed.

Abstract: A body protection assembly is disclosed for protecting a human body from injury due to an impact. An internal planar structure (102) defines the shape of the apparatus and an outer layer of a flexible sheet material (105) has a shape defined by the internal planar structure. The internal planar structure is constructed from a plurality of cells such that, in response to an impact, the cells at the position of an impact region deform to absorb kinetic energy. Furthermore, the outer layer of flexible sheet material extends the size of the impact region so as to increase the number of cells that absorb this kinetic energy.

Abstract: The application discloses a flexible strap for retaining protective eyewear on a wearer's head. The strap includes an energy absorbing material which is configured to deform to absorb kinetic energy on impact and which is held in contact with a first outer layer. A method of manufacture of the strap is also disclosed.

Abstract: Non ligand binding pocket antagonists for the human androgen receptor. The androgen receptor (AR) is a member of the Nuclear Receptor (NR) family and its role is to modulate the biological effects of the endogenous androgens, testosterone (tes) and dihydrotestosterone (DHT). Synthetic androgens and anti-androgens have therapeutic value in the treatment of various androgen dependent conditions, from regulation of male fertility to prostate cancer. Current treatment of prostate cancer (PCa) typically involves administration of ‘classical’ antiandrogens, competitive inhibitors of natural AR ligands, DHT and tes, for the ligand binding pocket (LBP) in the C-terminal ligand binding domain (LBD) of the AR. However, prolonged LBP-targeting can often lead to androgen resistance and alternative therapies and therapeutic strategies are urgently required. Disclosed herein are a class of non-steroidal, small molecule AR antagonists which inhibit the transcriptional activity of the AR by non LBP-mediated modulation.

Abstract: A body protection assembly is disclosed for protecting a human body from injury due to an impact. An internal planar structure (102) defines the shape of the apparatus and an outer layer of a flexible sheet material (105) has a shape defined by the internal planar structure. The internal planar structure is constructed from a plurality of cells such that, in response to an impact, the cells at the position of an impact region deform to absorb kinetic energy. Furthermore, the outer layer of flexible sheet material extends the size of the impact region so as to increase the number of cells that absorb this kinetic energy.

Abstract: Non ligand binding pocket antagonists for the human androgen receptor. The androgen receptor (AR) is a member of the Nuclear Receptor (NR) family and its role is to modulate the biological effects of the endogenous androgens, testosterone (tes) and dihydrotestosterone (DHT). Synthetic androgens and anti-androgens have therapeutic value in the treatment of various androgen dependent conditions, from regulation of male fertility to prostate cancer. Current treatment of prostate cancer (PCa) typically involves administration of ‘classical’ antiandrogens, competitive inhibitors of natural AR ligands, DHT and tes, for the ligand binding pocket (LBP) in the C-terminal ligand binding domain (LBD) of the AR. However, prolonged LBP-targeting can often lead to androgen resistance and alternative therapies and therapeutic strategies are urgently required. Disclosed herein are a class of non-steroidal, small molecule AR antagonists which inhibit the transcriptional activity of the AR by non LBP-mediated modulation.

Abstract: Described are compounds having a thiazolhydrazide scaffold, pharmaceutically acceptable salts of these compounds and pharmaceutical compositions containing at least one of these compounds together with pharmaceutically acceptable carrier, excipient and/or diluents. Said thiazolhydrazide compounds can be used for prophylaxis and/or treatment of neurodegenerative diseases and conditions.

Abstract: Described are compounds having a thiazolhydrazide scaffold, pharmaceutically acceptable salts of these compounds and pharmaceutical compositions containing at least one of these compounds together with pharmaceutically acceptable carrier, excipient and/or diluents. Said thiazolhydrazide compounds can be used for prophylaxis and/or treatment of neurodegenerative diseases and conditions.

Abstract: Compounds represented by the following structure (II) are disclosed: as are methods for making such compounds. Compositions and methods for treating various disease conditions including cancer and non-cancer diseases associated with vascular proliferation are also disclosed.

Abstract: Compounds represented by the following structure (I) are disclosed: as are methods for making such compounds, wherein said methods comprise reacting a diacyldiketopiperazine with a first aldehyde to produce an intermediate compound; and reacting the intermediate compound with a second aldehyde to produce the class of compounds with the generic structure, where the first aldehyde and the second aldehydes are selected from the group consisting of an oxazolecarboxaldeyhyde, imidazolecarboxaldehyde, a benzaldehyde, imidazolecarboxaldehyde derivatives, and benzaldehyde derivatives, thereby forming the above compound wherein R1, R1?, R1?, R2, R3, R4, R5, and R6, X1 and X2, Y, Z, Z1, Z2, Z3, and Z4 may each be separately defined in a manner consistent with the accompanying description. Compositions and methods for treating vascular proliferation are also disclosed.

Abstract: A measurement probe (10) is disclosed having strain sensing elements (36) mounted on spokes (38) of a strain sensing member (34). The member (34) is disposed in parallel and spaced from a diaphragm (42). Inner portions of the member and diaphragm are connected to a stylus holder (26) and outer portions of the member and diaphragm are connected to probe body (32). The probe can be used to produce a signal when contact force on the stylus (12) is within an adjustable upper and lower limit, and is thereby suited to use with a manually manipulatable coordinate measuring device.