Patents by Inventor George Luke
George Luke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11795168Abstract: The present disclosure is directed to solid and salt forms of inhibitors of the CBP/p300 family of bromodomains made up of salts and crystalline forms of Formula (I). The compounds can be useful in the treatment of disease or disorders associated with the inhibition of the CBP/p300 family of bromodomains. For instance, the disclosure is concerned with compounds and compositions for inhibition of the CBP/p300 family of bromodomains, methods of treating diseases or disorders associated with the inhibition of CBP/p300 family of bromodomains (e.g., certain forms of cancer), and methods of synthesis of these compounds.Type: GrantFiled: September 23, 2021Date of Patent: October 24, 2023Assignee: Forma Therapeutics, Inc.Inventors: George Luke, Suresh Babu
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Publication number: 20220089594Abstract: The present disclosure is directed to solid and salt forms of inhibitors of the CBP/p300 family of bromodomains made up of salts and crystalline forms of Formula (I). The compounds can be useful in the treatment of disease or disorders associated with the inhibition of the CBP/p300 family of bromodomains. For instance, the disclosure is concerned with compounds and compositions for inhibition of the CBP/p300 family of bromodomains, methods of treating diseases or disorders associated with the inhibition of CBP/p300 family of bromodomains (e.g., certain forms of cancer), and methods of synthesis of these compounds.Type: ApplicationFiled: September 23, 2021Publication date: March 24, 2022Inventors: George LUKE, Suresh BABU
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Patent number: 7669487Abstract: A desorber for use with a chemical ionisation mass spectrometer comprises a body portion that has a cavity formed therein, the cavity being arranged to receive a sample collector, the sample collector being preferably carried by a holding device that can be slid in and out of the cavity. The body portion includes an air intake passage in communication with the cavity and at least one heating element arranged to heat air drawn through the air intake passage into the cavity.Type: GrantFiled: April 5, 2005Date of Patent: March 2, 2010Assignee: Mass Spec Analytical Ltd.Inventors: John George Luke, Richard Sleeman
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Patent number: 7357044Abstract: A sample collection device for use with a chemical analyzer, the device comprising a sample collecting assembly having at least one sampling medium and a sample desorbing assembly arranged to receive the sampling medium therein, the sample collecting assembly and sample desorbing assembly being movable with respect to one another between a sample collecting configuration in which the sampling medium is substantially exposed and a sample desorbing configuration in which the sampling medium is substantially housed within the sample desorbing assembly.Type: GrantFiled: May 11, 2005Date of Patent: April 15, 2008Assignee: Mass Spec Analytical Ltd.Inventors: Richard Sleeman, John George Luke, Samantha Ollerton
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Publication number: 20070249616Abstract: Compounds of Formula I are provided, in which variables are as described herein: Such compounds may be used to modulate MCH binding to MCH receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting MCH receptors (e.g., receptor localization studies).Type: ApplicationFiled: June 15, 2007Publication date: October 25, 2007Applicant: NEUROGEN CORPORATIONInventors: Alan Hutchison, Bertrand Chenard, James Tarrant, Guiying Li, Manuka Ghosh, George Luke, John Peterson, Wallace Pringle, Mary-Margaret O'Donnell, Kyungae Lee, Linda Gustavson, Dario Doller
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Patent number: 7275636Abstract: A transport roller suspension mechanism for supporting at least one transport roller of a sample transport mechanism for introducing a substantially planar sample carrier to a chemical analysis device, the transport roller mechanism comprising: a suspension block arranged to be pivotally connected to a fixed portion of the sample transport mechanism and being arranged to rotatably receive one end of a transport roller shaft; and a biasing member arranged to be resiliently urged against the suspension block.Type: GrantFiled: April 5, 2005Date of Patent: October 2, 2007Assignee: Mass Spec Analytical Ltd.Inventors: John George Luke, Richard Sleeman
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Publication number: 20070208048Abstract: The invention provides Aryl substituted imidazoles, pyrazoles, pyridizines and related compounds of the Formula where the ring system represented by is a 5 membered heteroaryl ring system, in which x is 0, A is chosen from carbon and heteroatoms nitrogen, oxygen, and sulfur, and E and G are independently carbon or nitrogen provided that the 5 membered heteroaryl ring system does not contain more than 3 heteroatoms or more than 1 oxygen or sulfur atom, or a 6 membered heteroaryl ring system, in which x is 1, A, B, E, and G are independently chosen from carbon and nitrogen, provided that the 6 membered heteroaryl ring system does not contain more than 3 nitrogen atoms. The remaining variables, Ar1, Ar2, R, R1, R2, R3, R4, R5, R6, y and z are defined herein Such compounds are ligands of C5a receptors. Preferred compounds of the invention act bind to C5a receptors with high affinity and exhibit neutral antagonist or inverse agonist activity at C5a receptors.Type: ApplicationFiled: March 1, 2007Publication date: September 6, 2007Inventors: George Luke, George Maynard, Scott Mitchell, Andrew Thurkauf, Linghong Xie, LuYan Zhang, Suoming Zhang, He Zhao, Bertrand Chenard, Yang Gao, Bingsong Han, Xiao He
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Publication number: 20060142301Abstract: Compounds of Formula I are provided, in which variables are as described herein: Such compounds may be used to modulate MCH binding to MCH receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting MCH receptors (e.g., receptor localization studies).Type: ApplicationFiled: April 6, 2005Publication date: June 29, 2006Inventors: Alan Hutchison, Bertrand Chenard, James Tarrant, Guiying Li, Manuka Ghosh, George Luke, John Peterson, Wallace Pringle, Mary-Margaret O'Donnell, Kyungae Lee, Linda Gustavson, Dario Doller
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Publication number: 20060025425Abstract: This invention relates to benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds, all of which may be described by of Formula I The invention is particularly related to such compounds that bind with high selectivity and high affinity to the benzodiazepine site of GABAA receptors. This invention also relates to pharmaceutical compositions comprising such compounds and to the use of such compounds in treatment of certain central nervous system (CNS) diseases. Novel processes for preparing compounds of Formula I are disclosed. This invention also relates to the use of benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds of Formula I in combination with one or more other CNS agents to potentiate the effects of the other CNS agents. Additionally this invention relates to the use such compounds as probes for the localization of GABAA receptors in tissue sections.Type: ApplicationFiled: July 12, 2005Publication date: February 2, 2006Inventors: Guiying Li, Pamela Albaugh, Kevin Currie, Guolin Cai, Linda Gustavson, Kyungae Lee, Alan Hutchison, George Maynard, Jun Yuan, Ling Xie, Manuka Ghosh, Nian Liu, George Luke, Scott Mitchell, Martin Allen, Spiros Liras
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Publication number: 20060009456Abstract: Aryl-substituted piperazine derivatives are provided. Such compounds may be used to modulate MCH receptor activity in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting MCH receptors (e.g., receptor localization studies).Type: ApplicationFiled: June 16, 2005Publication date: January 12, 2006Inventors: Alan Hutchinson, Bertrand Chenard, Guiying Li, Manuka Ghosh, James Tarrant, Taeyoung Yoon, George Luke, Kyungae Lee, Mary-Margaret O'Donnell, Wallace Pringle, John Peterson, Kevin Hodgetts, Cheryl Steenstra, Dario Doller
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Publication number: 20050239791Abstract: Compounds of Formula I are provided, in which variables are as described herein: Such compounds may be used to modulate MCH binding to MCH receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting MCH receptors (e.g., receptor localization studies).Type: ApplicationFiled: April 6, 2005Publication date: October 27, 2005Inventors: Alan Hutchison, Bertrand Chenard, George Luke, Guiying Li, Manuka Ghosh, John Peterson, James Tarrant, Dario Doller
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Patent number: 6949562Abstract: Disclosed are heterocyclic compounds of the formula and the pharmaceutically acceptable salts thereof wherein the variables A, V, Y, J, E, X, T, G, Q, W, Z, b, n and m are defined herein. These compounds are highly selective agonists, antagonists or inverse agonists for GABAA brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAA brain receptor.Type: GrantFiled: September 23, 2003Date of Patent: September 27, 2005Assignees: Neurogen Corporation, Pfizer, Inc.Inventors: Daniel Yohannes, George Maynard, Jun Yuan, Linghong Xie, Kyungae Lee, Manuka Ghosh, George Luke, Xiaojun Liu, Arthur Nagal, Lawrence Vincent, Kevin Currie, Zhe-Quing Wang
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Publication number: 20040110778Abstract: Disclosed are heterocyclic compounds of the formula 1Type: ApplicationFiled: September 23, 2003Publication date: June 10, 2004Inventors: Daniel Yohannes, George Maynard, Jun Yuan, Linghong Xie, Kyungae Lee, Manuka Ghosh, George Luke, Xiaojun Liu, Arthur Nagal, Lawrence Vincent, Kevin Currie, Zhe-Quing Wang
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Patent number: 6653471Abstract: Disclosed are heterocyclic compounds of the formula and the pharmaceutically acceptable salts thereof wherein the variables A, V, Y, J, E, X, T, G, Q, W, Z, b, n and m are defined herein. These compounds are highly selective agonists, antagonists or inverse agonists for GABAA brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAA brain receptor.Type: GrantFiled: August 6, 2001Date of Patent: November 25, 2003Assignee: Neurogen CorporationInventors: Daniel Yohannes, George Maynard, Jun Yuan, Linghong Xie, Kyungae Lee, Manuka Ghosh, George Luke, Xiaojun Liu, Arthur Nagal, Lawrence Vincent, Kevin Currie, Zhe-Quing Wang
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Publication number: 20030105081Abstract: Disclosed are heterocyclic compounds of the formula 1Type: ApplicationFiled: August 6, 2001Publication date: June 5, 2003Inventors: Daniel Yohannes, George Maynard, Jun Yuan, Linghong Xie, Kyungae Lee, Manuka Ghosh, George Luke, Xiaojun Liu, Arthur Nagel, Lawrence Vincent, Kevin Currie, Zhe-Quing Wang
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Patent number: 5604642Abstract: The invention provides method and apparatus for making light-weight honeycomb mirrors by assembling fused quartz ribs in a honeycomb pattern so that rib ends are proximate other rib ends to form rib junctions. A laser beam is then directed at the rib junctions to weld the rib ends together to form a honeycomb structure having a plurality of rib-defined cells or modules therein. Fused quartz plates of matching size are then positioned across the so-formed rib cells and welded by directing a high powered laser beam at the edges of the plates and adjacent ribs to weld the plates to the rib cells of the honeycomb structure and define a honeycomb mirror blank. The surface of the plates of, e.g. fused quartz, are then ground and polished to a mirror finish and a reflective coating added, to complete the light-weight honeycomb mirror by the method and apparatus of the invention.Type: GrantFiled: January 20, 1995Date of Patent: February 18, 1997Assignee: The United States of America as represented by the Secretary of the Air ForceInventors: Czeslaw Deminet, George Luke
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Patent number: 3950948Abstract: Hydraulic control apparatus for automatic remote control of a hydraulic actuating ram. The apparatus has a double-acting slave cylinder connectable hydraulically to an actuating ram, and a double-acting master cylinder the piston of which is mechanically connected to the piston of the slave cylinder, the master cylinder being operable by hydraulic pressure supplied via a pilot-operated valve arranged automatically to reverse the stroke of the master ram at limits set according to the desired stroke of the actuating ram. The control apparatus may be used for controlling actuating rams which effect reciprocating pivotal movement about one or more axes of a water jet monitor.Type: GrantFiled: September 13, 1974Date of Patent: April 20, 1976Assignee: English Clays Lovering Pochin & Company LimitedInventor: William George Luke