Abstract: The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to amplified epidermal growth factor receptor (EGFR) and to the de2-7 EGFR truncation of the EGFR. In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof, is enhanced or evident upon aberrant post-translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. The binding members of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof.

Abstract: A workload manager is operable with a distributed transaction processor having a plurality of processing regions and comprises: a transaction initiator region for initiating a transaction; a transaction router component for routing an initiated transaction to one of the plurality of processing regions; an affinity controller component for restricting transaction routing operations to maintain affinities; the affinity controller component characterized in comprising a unit of work affinity component operable with a resource manager at the one of the plurality of processing regions to activate an affinity responsive to completion of a recoverable data operation at the one of the plurality of processing regions.

Abstract: A workload manager is operable with a distributed transaction processor having a plurality of processing regions and comprises: a transaction initiator region for initiating a transaction; a transaction router component for routing an initiated transaction to one of the plurality of processing regions; an affinity controller component for restricting transaction routing operations to maintain affinities; the affinity controller component characterised in comprising a unit of work affinity component operable with a resource manager at the one of the plurality of processing regions to activate an affinity responsive to completion of a recoverable data operation at the one of the plurality of processing regions.

Abstract: A method for automatically deriving a command for starting a program in an operating system of a computer, the method comprising the steps of: identifying an address space provided by an operating system; identifying a program in the address space; searching data logged by the operating system as a result of processing the identified program to identify a start command for initiating processing of the identified program; and outputting the identified start command.

Abstract: An apparatus and program product for automatically deriving a command for starting a program in an operating system of a computer, the method comprising the steps of: identifying an address space provided by an operating system; identifying a program in the address space; searching data logged by the operating system as a result of processing the identified program to identify a start command for initiating processing of the identified program; and outputting the identified start command.

Abstract: A workload manager is operable with a distributed transaction processor having a plurality of processing regions and comprises: a transaction initiator region for initiating a transaction; a transaction router component for routing an initiated transaction to one of the plurality of processing regions; an affinity controller component for restricting transaction routing operations to maintain affinities; the affinity controller component characterised in comprising a unit of work affinity component operable with a resource manager at the one of the plurality of processing regions to activate an affinity responsive to completion of a recoverable data operation at the one of the plurality of processing regions.

Abstract: A method, apparatus and program product for automatically deriving a command for starting a program in an operating system of a computer, the method comprising the steps of: identifying an address space provided by an operating system; identifying a program in the address space; searching data logged by the operating system as a result of processing the identified program to identify a start command for initiating processing of the identified program; and outputting the identified start command.

Abstract: A method, apparatus and program product for automatically deriving a command for starting a program in an operating system of a computer, the method comprising the steps of: identifying an address space provided by an operating system; identifying a program in the address space; searching data logged by the operating system as a result of processing the identified program to identify a start command for initiating processing of the identified program; and outputting the identified start command.

Abstract: A workload manager is operable with a distributed transaction processor having a plurality of processing regions and comprises: a transaction initiator region for initiating a transaction; a transaction router component for routing an initiated transaction to one of the plurality of processing regions; an affinity controller component for restricting transaction routing operations to maintain affinities; the affinity controller component characterised in comprising a unit of work affinity component operable with a resource manager at the one of the plurality of processing regions to activate an affinity responsive to completion of a recoverable data operation at the one of the plurality of processing regions.

Abstract: A combination lock to be installed on a panel such as a safe door, with a manually operable knob and dial at the front of the panel and the main part of the combination mechanism at the rear of the panel. A rotary operating spindle attached to the dial and a stationary bushing surrounding the spindle extend through the thickness of the panel and are made of non-metallic material having low heat conductivity, such as nylon. An operating or driving wheel or disk fixed to the rear end of the spindle has a projection for engaging and rotating a locking wheel or disk rotatable on the bushing in front of the operating disk, and this locking wheel engages and rotates another locking wheel in front of it. When radial slots in the locking wheel and the operating wheel are all in a predetermined alignment, a spring moves a finger on a slide member into the aligned slots, and this moves the latch bolt to an unlocked position.

Abstract: A heat absorbing body made from a mixture of water, Portland cement, cellulose fibers, and a foaming agent, with or without other ingredients such as water glass and sodium sulfate. Polypropylene fibers may be used in place of part or all of the cellulose fibers. Cellulose fibers (conveniently reclaimed or recycled cellulose fibers) are preferably used because of their ability to absorb and retain relatively large amounts of water in the composition. Various formulas are given for the mixture. The material is used as a filling for the walls of fire resistant safes and storage boxes, and also for the construction of structural panels for furniture and building construction, and for cast-in-place walls and floors and roofs of buildings.

Abstract: A safe has a self-sealing jamb where the door confronts and fits together with the box. This is done by forming the confronting surfaces in the jamb region of a resin material and making the jamb region non-linear in cross section and long enough in cross section so that after an outer portion of the resin material is burned off in a fire, a charred residue and a plasticized portion of the resin material remain in the jamb region to seal the door to the box around the jamb region for substantially preventing heat conduction or passage of hot gasses through the jamb region to the interior of the box. The safe can also be formed in a resin mold for the box and the door with the mold remaining in place when the safe is used. The mold is preferably filled with a non-flammable, thermal insulating material having a substantial volume of chemically bonded water and made thick enough to maintain the interior of the box below 180.degree. C for one hour in an ambient atmosphere of about 927.degree. C.