Patents by Inventor George M. Plotkin

George M. Plotkin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4577160
    Abstract: This disclosure is concerned with novel techniques and circuit configurations for rendering high gain operational amplifiers and related differencing amplifiers adaptable for use with very low impedance signal sources to permit amplification of low-power signals with ultra-low noise, high D. C. stability, high gain, and wide frequency response, through development of the signal current as a very small increment on a much larger pre-existing current forced in opposite directions through an electronic switching device connected to such amplifier and producing minimal uncorrelated noise therein.
    Type: Grant
    Filed: December 22, 1983
    Date of Patent: March 18, 1986
    Assignee: Robert H. Rines
    Inventors: Jerome Y. Lettvin, George M. Plotkin
  • Patent number: 4496539
    Abstract: This invention discloses a method of using galactose-binding lectins, such as Ricinus communis agglutinin I (RCA.sub.I), to kill cancer cells. RCA.sub.I has been found to severely weaken certain types of cancer cells, such as bladder carcinoma. This weakening can kill substantial numbers of cancer cells. In addition, it is possible to attach RCA.sub.I to other substances which impose stress on cells, such as cytotoxic drugs or enzymes that catalyze exothermic reactions, which can kill weakened cancer cells.
    Type: Grant
    Filed: February 1, 1982
    Date of Patent: January 29, 1985
    Assignee: Massachusetts Institute of Technology
    Inventors: George M. Plotkin, Charles J. Bendrick, George Wolf
  • Patent number: 4334017
    Abstract: An improved method for assaying for cancer by detecting .beta.-linked galactose moieties associated with cells is disclosed wherein a label specific for such moieties is added to the cells and subsequently sensed.
    Type: Grant
    Filed: March 16, 1981
    Date of Patent: June 8, 1982
    Assignee: Massachusetts Institute of Technology
    Inventors: George M. Plotkin, George Wolf
  • Patent number: 4228405
    Abstract: There is disclosed a novel compact power oscillator which is normally quiescent until applied to a load, to produce, under load, a unique waveform which has a unique application to self-protective devices and medical uses. The oscillator includes a high gain inverting amplifier, preferably a Darlington pair constituted by a germanium output transistor driven by a small signal transistor, a transformer, a D.C. source such as a battery, and a pair of output electrodes.
    Type: Grant
    Filed: April 23, 1979
    Date of Patent: October 14, 1980
    Assignee: VRL Growth Associates, Incorporated
    Inventors: Kevin G. Rhoads, George M. Plotkin
  • Patent number: 4132600
    Abstract: An enzymatic noninvasive method for detecting cancer in mammalian tissue is disclosed. This method comprises incubating exfoliated cells from mammalian tissue suspected of containing cancerous cells, and assaying them for galactosyl transferase activity. The level of galactosyl transferase activity has been found to be significantly altered in cells from cancerous tissue as compared to the level in cells from normal tissue.
    Type: Grant
    Filed: June 1, 1977
    Date of Patent: January 2, 1979
    Assignee: Massachusetts Institute of Technology
    Inventors: George M. Plotkin, George Wolf