Abstract: The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to amplified epidermal growth factor receptor (EGFR) and to the de2-7 EGFR truncation of the EGFR. In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof, is enhanced or evident upon aberrant post-translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. The binding members of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof.

Abstract: A method and apparatus is provided to assure transformations between applications in an integration project. This assurance of transformations between applications includes mapping one or more related fields from a set of fields between the one or more source applications and the one or more target applications according to a set of integration objectives, checking a type compatibility for each of the one or more related fields mapped between the one or more source applications and the one or more target applications and indicating a mapping status according to the type compatibility between the source applications and the target applications.

Abstract: A method and apparatus is provided to discover and integrate applications in an application router framework. The discovery operation includes receiving a registration notification for an application on a network, adding information describing the application to a repository into a data structure and publishing the data structure onto an application router. The association operations include querying one or more application routers on an application network for meta-data and other information on applications, exchanging the meta-data and other information between the application routers and associating the applications together automatically using their respective application protocols.

Abstract: A method and apparatus is provided to discover and integrate applications in an application router framework. The discovery operation includes receiving a registration notification for an application on a network, adding information describing the application to a repository into a data structure and publishing the data structure onto an application router. The association operations include querying one or more application routers on an application network for meta-data and other information on applications, exchanging the meta-data and other information between the application routers and associating the applications together automatically using their respective application protocols.

Abstract: A method and apparatus is provided to discover and integrate applications in an application router framework. The discovery operation includes receiving a registration notification for an application on a network, adding information describing the application to a repository into a data structure and publishing the data structure onto an application router. The association operations include querying one or more application routers on an application network for meta-data and other information on applications, exchanging the meta-data and other information between the application routers and associating the applications together automatically using their respective application protocols.

Abstract: Techniques are provided to discover and integrate applications in an application router framework. The discovery operation includes receiving a registration notification for an application on a network, adding information describing the application to a repository into a data structure and publishing the data structure onto an application router. Association operations include querying one or more application routers on an application network for meta-data and other information on applications, exchanging the meta-data and other information between the application routers and associating the applications together automatically using their respective application protocols.

Abstract: A method, apparatus and computer program product is provided to create an integration process between a source system and target system. The integration method and system includes creating a mapping between one or more source objects and one or more target objects as part of an integration process between a respective source system and target system. The complete workflow has a sequence of activities that specifies operations on the one or more source objects and one or more target objects as between the respective source system and target system, including the mapping between one or more source objects and one or more target objects. Next, one implementation selectively includes a limited subset of operations from the sequence of activities in the complete workflow that interact with the one or more source objects and one or more target objects. These selective objects, operations and activities are identified as generally needing modification when performing an integration process.

Abstract: Techniques are provided to discover and integrate applications in an application router framework. The discovery operation includes receiving a registration notification for an application on a network, adding information describing the application to a repository into a data structure and publishing the data structure onto an application router. Association operations include querying one or more application routers on an application network for meta-data and other information on applications, exchanging the meta-data and other information between the application routers and associating the applications together automatically using their respective application protocols.

Abstract: A method, apparatus and computer program product is provided to create an integration process between a source system and target system. The integration method and system includes creating a mapping between one or more source objects and one or more target objects as part of an integration process between a respective source system and target system. The complete workflow has a sequence of activities that specifies operations on the one or more source objects and one or more target objects as between the respective source system and target system, including the mapping between one or more source objects and one or more target objects. Next, one implementation selectively includes a limited subset of operations from the sequence of activities in the complete workflow that interact with the one or more source objects and one or more target objects. These selective objects, operations and activities are identified as generally needing modification when performing an integration process.

Abstract: A method and apparatus is provided to discover and integrate applications in an application router framework. The discovery operation includes receiving a registration notification for an application on a network, adding information describing the application to a repository into a data structure and publishing the data structure onto an application router. The association operations include querying one or more application routers on an application network for meta-data and other information on applications, exchanging the meta-data and other information between the application routers and associating the applications together automatically using their respective application protocols.

Abstract: A method and apparatus is provided to discover and integrate applications in an application router framework. The discovery operation includes receiving a registration notification for an application on a network, adding information describing the application to a repository into a data structure and publishing the data structure onto an application router. The association operations include querying one or more application routers on an application network for meta-data and other information on applications, exchanging the meta-data and other information between the application routers and associating the applications together automatically using their respective application protocols.

Abstract: A method and apparatus is provided to discover and integrate applications in an application router framework. The discovery operation includes receiving a registration notification for an application on a network, adding information describing the application to a repository into a data structure and publishing the data structure onto an application router. The association operations include querying one or more application routers on an application network for meta-data and other information on applications, exchanging the meta-data and other information between the application routers and associating the applications together automatically using their respective application protocols.

Abstract: A method and apparatus is provided to discover and integrate applications in an application router framework. The discovery operation includes receiving a registration notification for an application on a network, adding information describing the application to a repository into a data structure and publishing the data structure onto an application router. The association operations include querying one or more application routers on an application network for meta-data and other information on applications, exchanging the meta-data and other information between the application routers and associating the applications together automatically using their respective application protocols.

Abstract: An audio signal transmission system to be used on commercial airlines for the discrete transmission of voice conversations emanating from the cockpit of the aircraft automatically to a ground tracking station or a tracking aircraft in an emergency situation, sich as a hijacking, unbeknownst to occupants of the cockpit other than the crew members. The transmission system comprises an audio switching assembly which, when activated, transfers audio signals from a voice recorder assembly normally found on commercial aircraft to a radio transceiver of the aircraft for automatic transmission to ground tracking stations. Activation of the system can occur by a crew member carrying out his normal activities therefore not alerting hijackers when performing either one or both of the duties relating to setting the dual transponder control to a preselected code setting and/or the frequency channel selector of the radio transceiver to a preselected frequency.

Abstract: A novel gas lift apparatus is described which is particularly useful for the dewatering of gas wells in which the gas pressure is low or for the lifting of oil from wells when mixed oil and gas are produced. Water or oil is allowed to collect in the tubing above the valve of the apparatus. Sensors provide indications of the water level or the hydrostatic head within the tubing, and of the gas pressure in the casing. The outputs of the sensors are fed to an electronic, pneumatic or hydraulic controller which at a predetermined differential pressure opens the valve. Alternatively, a timer can be used to energize the valve at a predetermined time.