Abstract: The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to amplified epidermal growth factor receptor (EGFR) and to the de2-7 EGFR truncation of the EGFR. In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof, is enhanced or evident upon aberrant post-translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. The binding members of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof.

Abstract: A method and apparatus is provided for integrating an application into a network of computing resources. Applications using this integration have a virtualized access to one or more computing resources associated with the network. Virtualization is generally assured through at least one network connection between the virtual layer and the native network. Together, the virtual access is used to generate a virtual application network capable of providing the application access to the network of computing resources. The application is created into an orchestration of operations to manipulate the one or more computing resources according to a business process. As needed, the application and orchestration can be further partitioning into components to be distributed and executed over the virtual application network using the virtualized access.

Abstract: A method and apparatus is provided for integrating an application into a network of computing resources. Applications using this integration have a virtualized access to one or more computing resources associated with the network. Virtualization is generally assured through at least one network connection between the virtual layer and the native network. Together, the virtual access is used to generate a virtual application network capable of providing the application access to the network of computing resources. The application is created into an orchestration of operations to manipulate the one or more computing resources according to a business process. As needed, the application and orchestration can be further partitioning into components to be distributed and executed over the virtual application network using the virtualized access.

Abstract: An Object Request Broker (ORB) working in the Common Object Request Broker Architecture (CORBA) is structured to handle the registration of multiple and diverse communications protocols. The protocol engine of the ORB has it architecture modified so that it can accept a plug-in component which has a protocol connector and a protocol adapter portion for communication between client and server applications, respectively. The plug-in converts from the client/server applications to the General Inter-ORB Protocol used by the ORB. The plug-in will be fully operational if it has an interface to the rest of the ORB as required by the invention, including a protocol connection interface for the connector interface and Listener and Dispatcher interfaces for the server-adaptor interface.