Abstract: Disclosed herein are methods for detecting differentially methylated CpG islands associated with epigenetic changes in a subject using discrete cosine transform (DCT) and spectral clustering on non-native data. Based, in part, on algorithms continually improved through machine learning and the application of a combination of DCT and spectral clustering when applying a deep learning program on non-native data, the methods and systems generate a customized report on an individual's overall health. This contains a neural network-trained assessment of the individual's genome, including differences in DNA methylation and gene expression—quantitative results which can predict the onset of developing health concerns and conditions associated with aging.

Abstract: Disclosed herein are methods for detecting differentially methylated CpG islands associated with epigenetic changes in a subject. Based, in part, on algorithms continually improved through machine learning, the methods and systems generate a customized report on an individual's overall health. This contains a neural network-trained assessment of the individual's genome, including differences in DNA methylation and gene expression—quantitative results which can predict the onset of developing health concerns and conditions associated with aging. The results can then be privately and conveniently accessed and shared with health providers to deliver a qualitative assessment backed by clinical judgment, and to facilitate deploying targeted treatments of identified conditions associated with aging.

Abstract: A capacitive sensing system may include a fluid cup configured to receive a fluid, and processing circuitry and a capacitive sensor coupled to one another, the capacitive sensor is a distance separated from and in parallel with a top surface of the fluid in the fluid cup, the distance the capacitive sensor is separated from the top surface of the fluid being variable with a fill level of the fluid in the fluid cup. The capacitive sensor and the fluid in the fluid cup may form elements of a capacitor with a capacitance that is a function of at least the distance the capacitive sensor is separated from the top surface of the fluid. The processing circuitry may be configured to measure a change in signal corresponding to a change in capacitance of the capacitor and determine the fill level based on a magnitude of the change in signal.

Abstract: A solid-production system for producing a solid on demand is provided herein. In some aspects, the solid-production system includes a conveying mechanism; a fluid-dispensing mechanism; a pressure plate arranged to urge the fluid mold into interaction with a cooling block to form a solid; a solid-dispensing mechanism arranged to dispense the solid loosened by a solid ejector to a user; and processing circuitry configured to implement a master state machine, and slave state machines for respective ones of the fluid-dispensing mechanism, conveying mechanism, pressure plate and solid-dispensing mechanism, wherein the master state machine is configured to send commands to the slave state machines based on states of the slave state machines, and the slave state machines are configured to execute the commands to control the respective ones of the conveying mechanism, fluid-dispensing mechanism, pressure plate, and solid-dispensing mechanism.

Abstract: A solid-production system for producing a solid on demand is disclosed herein. In some aspects, the solid-production system includes a cooling block arranged to interact with one or more fluid molds to reduce a first temperature of a fluid dispensed in each of the one or more fluid molds to a second temperature, the second temperature being lower than the first temperature, to solidify the fluid in each of the one or more fluid molds; wherein the cooling block has a thermal mass operable to absorb and store thermal energy transferred by the fluid in each of the one or more fluid molds so as to reduce the first temperature of the fluid to the second temperature.

Abstract: A solid-production system for producing a solid on demand is provided herein. In some aspects, the solid-production system includes a conveying mechanism; a fluid-dispensing mechanism; a pressure plate arranged to urge the fluid mold into interaction with a cooling block to form a solid; a solid-dispensing mechanism arranged to dispense the solid loosened by a solid ejector to a user; and processing circuitry configured to implement a master state machine, and slave state machines for respective ones of the fluid-dispensing mechanism, conveying mechanism, pressure plate and solid-dispensing mechanism, wherein the master state machine is configured to send commands to the slave state machines based on states of the slave state machines, and the slave state machines are configured to execute the commands to control the respective ones of the conveying mechanism, fluid-dispensing mechanism, pressure plate, and solid-dispensing mechanism.

Abstract: A rotation detection system for detecting the rotation of a lock dial includes a magnet coupled to the lock dial to generate a changing magnetic field in response to rotation of the lock dial, a sensor disposed near enough to the magnet to detect the magnetic field and provide a sensor output signal indicative of the magnetic field, and a controller coupled to the sensor for receiving the sensor output signal, the controller providing a controller output signal in response to a change in the sensor output signal. An alarm interface can receive the controller output signal and provide an alarm signal.

Abstract: A lock assembly for securing a container having an interior region is provided. In one illustrative embodiment, the lock assembly includes a keypad having a plurality of buttons on a first surface of the keypad, a light-emitting diode, and a bezel surrounding at least a portion of the keypad. The bezel includes a reflective surface positioned to reflect a light from the light-emitting diode, the reflected light illuminating the plurality of buttons.

Abstract: A rotation detection system for detecting the rotation of a lock dial includes a magnet coupled to the lock dial to generate a changing magnetic field in response to rotation of the lock dial, a sensor disposed near enough to the magnet to detect the magnetic field and provide a sensor output signal indicative of the magnetic field, and a controller coupled to the sensor for receiving the sensor output signal, the controller providing a controller output signal in response to a change in the sensor output signal. An alarm interface can receive the controller output signal and provide an alarm signal.

Abstract: A lock assembly for securing a container having an interior region is provided. In one illustrative embodiment, the lock assembly includes a keypad having a plurality of buttons on a first surface of the keypad, a light-emitting diode, and a bezel surrounding at least a portion of the keypad. The bezel includes a reflective surface positioned to reflect a light from the light-emitting diode, the reflected light illuminating the plurality of buttons.

Abstract: Briefly described, embodiments of the present disclosure relate to methods and systems for identifying and classifying taxa of organohalide-respiring bacteria, including methods and systems for identify and classify two or more taxa of Dehalococcoides.

Abstract: A lock assembly for securing a container having an interior region is provided. In one illustrative embodiment, the lock assembly includes a keypad having a plurality of buttons on a first surface of the keypad, a light-emitting diode, and a bezel surrounding at least a portion of the keypad. The bezel includes a reflective surface positioned to reflect a light from the light-emitting diode, the reflected light illuminating the plurality of buttons.

Abstract: Briefly described, embodiments of the present disclosure relate to methods and systems for identifying and classifying taxa of organohalide-respiring bacteria, including methods and systems for identify and classify two or more taxa of Dehalococcoides.

Abstract: An extruder apparatus is disclosed and which includes a cylindrical barrel having a feed end and a discharge end, the feed end having an outlet in fluid communication with a feed box. The extruder screw is mounted in the cylindrical barrel, and the screw has an outer surface having one or more helical flights mounted thereon. The screw has a discharge end and a terminal end, wherein the screw further comprising a notch at the terminal end.

Abstract: A lock assembly (16) for securing a container (10) having an interior region is disclosed. The lock assembly (16) includes a housing (18) positionable on the interior of the container (10), a bolt (26) moveable relative to the housing (18) between an extended position inhibiting access to the interior region of the container (10) and a retracted position to facilitate access to the interior region, a dial (20) positionable on an exterior of the container (10). The dial (20) includes a plurality of indicators (30, 32) indicative of a plurality of dial positions, and an electronic controller (46) operably coupled to the dial (20) to detect the relative position of the dial (20) to determine if a combination entered with the dial (20) provides authorization to move the bolt (26) from the extended position to the retracted position.

Abstract: The present invention relates to toner compositions containing extra particulate additives. The additives may include a mixture of silica particles having differing BET surface areas and may include an acicular inorganic oxide. The control of such additives may be relied upon to control toner performance with respect to functional performance considerations such as filming and/or overall print quality.

Abstract: The present invention relates to toner compositions containing extra particulate additives. The additives may include a mixture of silica particles having differing BET surface areas and may include an acicular inorganic oxide. The control of such additives may be relied upon to control toner performance with respect to functional performance considerations such as filming and/or overall print quality.

Abstract: The present invention relates to the use of extra particulate additives in selected chemically processed toner compositions for use in an image forming apparatus. The extra particulate additive may have a controlled aspect ratio and be combined with the chemically processed toner. The chemically processed toner may provide toner particles having controlled diameters and rheological properties that may be combined with a release agent. The release agent may also be selected with respect to, e.g., concentration and/or mean domain size within the toner particles including considerations of coating chemistry and/or DSC melting behavior.

Abstract: A gear pump and method for pumping elastomeric material having two gears with meshing herringbone gear teeth. Each of the gear teeth has helical side portions and a curved central portion which extends circumferentially of the gear a distance equal to at least one half the pitch of the gear teeth to provide a continuous squeezing contact between the teeth of the two gears for pumping a uniform strip of elastomeric material from the gear pump.

Abstract: An electrosurgical instrument for use in cutting and/or coagulating tissue includes one or more electrode surfaces (15 and 16) at least partly coated with tungsten disulphide. The tungsten disulphide coating acts to reduce the incidence of tissue becoming adhered to the or each electrode surface (15, 16). Examples of electrosurgical instruments employing such coated electrodes include forceps, scissors or scalpel blade instruments.