Abstract: Heterocyclic compounds such as 3,4,5,6-tetrahydro-2,3,10-triaza-benzo[e]azulene-1-carboxylic acid arylamides, 5,7-Dihydro-6H-pyrazolo[3,4-h]quinoline-9-carboxylic acid arylamides, 5,7-Dihydro-6H-pyrazolo[3,4-h]quinazoline-9-carboxylic acid arylamides, 2,4,5,6-Tetrahydro-1,2,6,7-tetraaza-as-indacene-8-carboxylic acid arylamides and related compounds are disclosed. These compounds are highly selective agonists, antagonists or inverse agonists for GABAA brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAA brain receptors and are therefore useful in the treatment of anxiety, depression, sleep and seizure disorders, overdose with benzodiazepine drugs, Alzheimer's dementia, and for enhancement of memory. Pharmaceutical compositions, including packaged pharmaceutical compositions, are further provided. Intermediates useful for the synthesis of pyrazolecarboxylic acid arylamides are also provided.

Abstract: This invention relates to heteroaryl substituted fused bicyclic heteroaryl compounds, such as heteroaryl substituted imidazopyridines, imidazopyrazines, imidazopyridizines, imidazopyrimidines, and imidazothiazoles, which may be described by Formula I or Formula II: 1

Abstract: Disclosed are heterocyclic compounds of the formula 1

Abstract: This invention relates to cycloalkylpyrrole-3-carboxylic acid derivatives and heterocycloalkylpyrrole-3-carboxylic acid derivatives that bind with high selectively and/or high affinity to the benzodiazepine site of GABAA receptors. This invention also relates to pharmaceutical compositions comprising such compounds and to the use of such compounds in the treatment of central nervous system (CNS) diseases. This invention also relates to the use of these cycloalkylpyrrole-3-carboxylic acid derivatives and heterocycloalkylpyrrole-3-carboxylic acid derivatives in combination with one or more other CNS agents to potentiate the effects of the other CNS agents. Additionally this invention relates to the use such compounds as probes for the detection of GABAA receptors in tissue samples.

Abstract: An information management, retrieval and display system searches through an informational resource, such as a document (e.g., a treaty), a number of individual documents (e.g., Web pages resident on the Internet), or a stream of information (e.g., DNA code, source code, satellite data transmissions, etc.) and displays the results of the search in an collapsible/expandable format based upon a user-selected display criteria or hierarchy. Such a display hierarchy will allow the end-user to effectively and quickly obtain items of interest from the search results.

Abstract: Disclosed are compounds of the formula 1

Abstract: Disclosed are compounds of the formula 1

Abstract: Disclosed are compounds of the formula: 1

Abstract: An information management, retrieval and display system searches through an informational resource, such as a document (e.g., a treaty), a number of individual documents (e.g., Web pages resident on the Internet), or a stream of information (e.g., DNA code, source code, satellite data transmissions, etc.) and displays the results of the search in an collapsible/expandable format based upon a user-selected display criteria or hierarchy. Such a display hierarchy will allow the end-user to effectively and quickly obtain items of interest from the search results.

Abstract: A multichannel radiotelephony system provides two way cordless communications with a plurality of multichannel transceivers portable within a coverage area comprised by a plurality of cells, each associated with a base station and antennas, such as to permit channel frequency reuse in cells within the coverage area. For at least part of the coverage area, the locations of the antennas within the cells and the locations of the base stations are independently mapped, the antennas being associated with active antenna systems and the active antenna systems being connected to the base stations utilizing broadband transmission by means of a fixed bi-directional signal distribution network. The network is connected to the base stations and the antenna systems through suitable interfaces incorporating frequency translation so that available frequency bands in the signal distribution network which will normally be shared with other services, may be utilised. Plural base stations may be co-located.

Abstract: A multichannel radiotelephony system provides two way cordless communications with a plurality of multichannel transceivers portable within a coverage area comprised by a plurality of cells, each associated with a base station and antennas, such as to permit channel frequency reuse in cells within the coverage area. For at least part of the coverage area, the locations of the antennas within the cells and the locations of the base stations are independently mapped, the antennas being associated with active antenna systems and the active antenna systems being connected to the base stations utilizing broadband transmission by means of a fixed bi-directional signal distribution network. The network is connected to the base stations and the antenna systems through suitable interfaces incorporating frequency translation so that available frequency bands in the signal distribution network which will normally be shared with other services, may be utilised. Plural base stations may be co-located.