Abstract: The invention relates to the use of the benzo[b]-thiophene-2-carboximidamide derivative having formula I ##STR1## or pharmaceutically acceptable salts thereof, for the preparation of a medicament which is suitable for the treatment of heart failure, having high bioavailability without inducing nausea, vomiting and/or restlessness.

Abstract: A method is provided for treating patients suffering from or susceptible to bronchoconstriction, particularly for patients suffering from an asthmatic attach which comprises the use of benzothiophene, benzofuran, dihydronaphthalene or indene derivatives represented by formula I ##STR1## wherein each of R.sup.1, R.sup.2, R.sup.3 and R.sup.4 is independently H, (1-4C) alkyl, (1-4C) halogen substituted alkyl, OH, (1-4C) alkoxy, (1-4C) halogen substituted alkoxy, NO.sub.2, CN, halogen, an unsubstituted or (1-4C) alkyl substituted amino group, or wherein two adjacent groups R.sup.1, R.sup.2, R.sup.3 or R.sup.4 together form methylenedioxy;X is S, O or (CH.sub.2).sub.m in which m is 1 or 2;R.sup.5 is H or (1-4C) alkyl;R.sup.6 is H, NH.sub.2 or (1-4C) alkyl;R.sup.7 is H, (1-4C) alkyl or OR.sup.8 in whichR.sup.8 is H, (1-4C) alkyl or (1-8C) acyl;and its pharmaceutically acceptable salts for the preparation of a medicament with bronchodilator activity.

Abstract: The invention relates to pyridazinone compounds of the general formula I: ##STR1## wherein R.sup.1 represents one to four substituents, which may be the same or different and are selected from H, OH, halogen, NO.sub.2, unsubstituted or C1-C4 alkyl substituted amino, C1-C4 alkyl, C1-C4 halogen substituted alkyl, O--ALK--NR.sup.4 R.sup.5, C1-C4 alkoxy, whereby two substituents taken together may also represent a methylenedioxy group;R.sup.2 and R.sup.3 represent independently H or C1-C4 alkyl;R.sup.4 and R.sup.5 represent independently H or C1-C4 alkyl, or form together with the nitrogen a 5- or 6- membered ring;X represents S or O;the dotted line represents an optional bond;and their pharmaceutically acceptable salts.

Abstract: The present invention relates to novel 21-alkylated steroids of the pregnane series having the formula: ##STR1## wherein R.sub.1 =alkyl (1-4 C); R.sub.2 =carboxyacyl (1-18 C); X=H, F or Cl; Y=O, H(OH), H(lower acyloxy), H(F) or H(Cl) with the proviso that Y is not H(F) when X is F; and the dotted line indicates the optional presence of a double bond, to processes for their preparation and to pharmaceutical compositions containing same.The novel compounds possess strong anti-inflammatory properties, when applied locally and cause little or systemic, thymolytic, adrenolytic and salt-retaining effects.

Abstract: The invention relates to novel 21-alkylated steroids of the pregnane series having the formula: ##STR1## WHEREIN X = H or halogen;Y = h.sub.2, h(oh), h(oacyl), O or H(halogen);R.sub.1 = an alkyl group having 1-4 C-atoms;R.sub.2 = r.sub.1 or H;R.sub.3 = h, ch.sub.3 or halogen;Z = oh, oalkyl or Oacyl or form together with R.sub.4 a group as indicated below;Q = (when C.sub.15 -C.sub.16 is saturated) alkylidene having 1-4 C-atoms or (.beta.H) (.alpha.R.sub.4), in which R.sub.4 together with Z is alkylidenedioxy having 3-5 C-atoms, alkylidene having 1-4 C-atoms, aralkylidene having 7-8 C-atoms, alkylene of the formula ##STR2## wherein A = H or halogen and B = H, halogen, alkyl (1-4 C), haloalkyl, alkoxy or phenyl, or a [17.alpha.,16.alpha.-d]- or [16.alpha.,17.alpha.-d]-oxazolino-group, wherein the C-atom in 2'-position may be substituted by alkyl (1-4 C) or phenyl; or Q = (when C.sub.15 -C.sub.16 is unsaturated) methyl or halomethyl, and a process for obtaining same.

Abstract: The invention relates to novel alkylated steroids of the pregnane series having the formula: ##SPC1##, whereinX = a member of the group consisting of H and halogen;Y = a member of the group consisting of H.sub.2, H(OH), H(OAcyl) and O;R.sub.1 = a member of the group consisting of H, CH.sub.3 and halogen;R.sub.2 = alkyl having 1-4 carbon atoms;R.sub.3 = a member of the group consisting of H (except when Y = H.sub.2), OAcyl, Oalkyl, and CH.sub.3 ;R.sub.4 = a member of the group consisting of H and alkyl having 1-4 carbon atoms and in which at least one of the substituents R.sub.3 and R.sub.4 is alkyl; andC.sub.1 -c.sub.2 and C.sub.6 -C.sub.7 are selected from a saturated and an unsaturated bond.The novel compounds possess strong anti-inflammatory properties and are useful in the treatment of inflammatory conditions especially those associated with the skin and allergic reactions.