Patents by Inventor George Michael Luke

George Michael Luke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7364385
    Abstract: A flood control system including panels made from plastic sheeting adhered to a frame and stacked one on top of the other. The panels are held in position by a series of columns, each of the columns having an H-shaped cross section that provides for and defines panel receiving slot adapted and arranged to interact with gaskets on the panels to provide a water tight barrier.
    Type: Grant
    Filed: May 7, 2007
    Date of Patent: April 29, 2008
    Inventor: George Michael Luke
  • Patent number: 4112234
    Abstract: Compounds of the formula ##STR1## wherein R.sup.1 is a straight or branched chain alkynyl group containing from 3 to 9 carbon atoms, inclusive, and nontoxic pharmaceutically acceptable acid addition salts thereof, are potent anti-ulcer agents.
    Type: Grant
    Filed: November 7, 1977
    Date of Patent: September 5, 1978
    Assignee: Bristol-Myers Company
    Inventors: Ronnie Ray Crenshaw, George Michael Luke
  • Patent number: 4102885
    Abstract: A one-step process for the preparation of 2,4-dihaloquinazolines is disclosed beginning with methoxycarbonyl- or phenoxycarbonyl-derivatives of substituted phenylureas which are cyclized and concomitantly halogenated with a cyclizing-halogenating reagent such as N,N-dimethylaniline in phosphorus oxychloride. The 2,4-dihaloquinazolines of the instant process are particularly valuable as intermediates in the preparation of 4-amino-2-(4-substituted-piperazin-1-yl) quinazolines useful in the treatment of cardiovascular disorders such as hypertension.
    Type: Grant
    Filed: June 20, 1977
    Date of Patent: July 25, 1978
    Assignee: Bristol-Myers Company
    Inventors: Ronnie Ray Crenshaw, George Michael Luke, Richard Anthony Partyka
  • Patent number: 4098788
    Abstract: 2-Halo-4-aminoquinazolines are produced by a two-step process involving cyclization of 1-phenyl-3-cyanoureas or 1-phenyl-3-cyanothioureas in the presence of phosphorus halides and phosphorus oxyhalides to provide a phosphoquinazoline intermediate which is hydrolyzed to the quinazoline. Exemplary of the process is the intramolecular cyclization of 1-(3,4-dimethoxyphenyl)-3-cyanourea in the presence of phosphorus pentachloride and phosphorus oxychloride to a phosphoquinazoline intermediate which is subsequently hydrolyzed with formic acid to 2-chloro-4-amino-6,7-dimethoxy-quinazoline. The 2-halo-4-aminoquinazolines of the instant process are particularly valuable as intermediates in the preparation of 4-amino-2-(4-substituted-piperazin-l-yl)quinazolines useful in the treatment of cardiovascular disease, e.g. hypertension.
    Type: Grant
    Filed: June 20, 1977
    Date of Patent: July 4, 1978
    Assignee: Bristol-Myers Company
    Inventors: Ronnie Ray Crenshaw, George Michael Luke, Richard Anthony Partyka
  • Patent number: 4013665
    Abstract: Compounds of the formula ##SPC1##Where A is selected from the group consisting of hydrogen, halogen, lower alkoxy, lower alkylthio, hydroxyl, thio, trifluoromethyl, lower diakylaminoalkyl, amino, lower alkylamino and lower dialkylamino,Where B is selected from the group consisting of hydrogen, lower alkyl, lower alkoxyl, lower alkylthio, hydroxyl, thio, trifluoromethyl, lower dialkylaminoalkoxyl, amino, lower alkylamino, and lower dialkylamino,Where C is selected from the group consisting of hydrogen, halogen, lower alkyl, lower alkoxyl, lower alkylthio, hydroxyl, thio, trifluoromethyl, lower dialkylaminoalkoxy, amino, lower alkylamino and lower dialkylamino,Where D is selected from the group consisting of hydrogen, halogen, lower alkyl, lower alkoxy, lower alkylthio, hydroxyl, thio, trifluoromethyl, lower dialkylaminoalkoxyl, amino, lower alkylamino and lower diaklamino,Where n is an integer from 2 to 12 inclusive,And Y is selected from the group consisting of amino, lower alkylamino, lower dialkylamino, and
    Type: Grant
    Filed: October 1, 1973
    Date of Patent: March 22, 1977
    Assignee: Bristol-Myers Company
    Inventors: Ronnie Ray Crenshaw, George Michael Luke, Paul Siminoff