Patents by Inventor George N. Cox

George N. Cox has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hematopoietic Growth Factor Proteins and Analogs Thereof and Angiotensin Converting Enzyme Inhibitors for Treatment of Radiation Exposure
    Publication number: 20220202903
    Abstract: Methods and compositions comprising hematopoietic growth factor proteins and/or protein analogs thereof and/or combinations thereof and angiotensin converting enzyme inhibitors to treat the acute and long term adverse effects of radiation exposure in subjects who have been or will be exposed to radiation are disclosed.
    Type: Application
    Filed: December 13, 2021
    Publication date: June 30, 2022
    Inventors: George N. Cox, Christie M. Orschell, Meetha Manek Medhora, Brian Fish
  • Methods and Compositions for Enhancement of Stem Cell-based Immunomodulation and Tissue Repair
    Publication number: 20220033804
    Abstract: Provided herein are methods and compositions for enhancement of stem-cell based immunomodulation and promotion of tissue repair.
    Type: Application
    Filed: July 30, 2021
    Publication date: February 3, 2022
    Inventors: Andres J. Garcia, George N. Cox, Jose Garcia, Asma Nusrat, Miguel Angel Quiros Quesada
  • Hematopoietic growth factor proteins and analogs thereof and angiotensin converting enzyme inhibitors for treatment of radiation exposure
    Patent number: 11229683
    Abstract: Methods and compositions comprising hematopoietic growth factor proteins and/or protein analogs thereof and/or combinations thereof and angiotensin converting enzyme inhibitors to treat the acute and long term adverse effects of radiation exposure in subjects who have been or will be exposed to radiation are disclosed.
    Type: Grant
    Filed: September 19, 2016
    Date of Patent: January 25, 2022
    Assignees: Bolder Biotechnology, Inc., Indiana University Research and Technology Corporation, The Medical College of Wisconsin, Inc.
    Inventors: George N. Cox, Christie M. Orschell, Meetha Manek Medhora, Brian Fish
  • LONG ACTING PROTEINS AND PEPTIDES AND METHODS OF MAKING AND USING THE SAME
    Publication number: 20200283471
    Abstract: Disclosed is a method for refolding a protein or peptide that does not contain essential disulfides and that contains at least one free cysteine residue. Also disclosed are polymer IFN-? conjugates that have been created by the chemical coupling of polymers such as polyethylene glycol moieties to IFN-?, particularly via a free cysteine in the protein. Also disclosed are analogs of bioactive peptides that may be used to create longer acting versions of the peptides, including analogs of glucagon, glucagon-like peptide-1 (GLP-1), GLP-2, Gastric inhibitory peptide (GIP), PYY, exendin, ghrelin, gastrin, amylin, and oxyntomodulin.
    Type: Application
    Filed: October 25, 2019
    Publication date: September 10, 2020
    Inventors: George N. Cox, Mary S. Rosendahl
  • Methods and use of growth hormone supergene family protein analogs for treatment of radiation exposure
    Patent number: 10653752
    Abstract: Methods and compositions for the use of long-acting hematopoietic factor protein analogs for accelerating hematopoietic recovery in subjects who have been or will be exposed to radiation are disclosed.
    Type: Grant
    Filed: June 4, 2018
    Date of Patent: May 19, 2020
    Assignee: Bolder Bio Technology, Inc.
    Inventors: George N. Cox, Christie M. Orschell
  • Cysteine analogs of exendin-4
    Patent number: 10508131
    Abstract: Disclosed is a method for refolding a protein or peptide that does not contain essential disulfides and that contains at least one free cysteine residue. Also disclosed are polymer IFN-? conjugates that have been created by the chemical coupling of polymers such as polyethylene glycol moieties to IFN-?, particularly via a free cysteine in the protein. Also disclosed are analogs of bioactive peptides that may be used to create longer acting versions of the peptides, including analogs of glucagon, glucagon-like peptide-1 (GLP-1), GLP-2, Gastric inhibitory peptide (GIP), PYY, exendin, ghrelin, gastrin, amylin, and oxyntomodulin.
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: December 17, 2019
    Assignee: Bolder Biotechnology, Inc.
    Inventors: George N. Cox, Mary S. Rosendahl
  • CYSTEINE VARIANTS OF INTERLEUKIN-11 AND METHODS OF USE THEREOF
    Publication number: 20190270787
    Abstract: Disclosed are cysteine variants of interleukin-11 (IL-11) and methods of making and using such proteins in therapeutic applications.
    Type: Application
    Filed: May 10, 2019
    Publication date: September 5, 2019
    Inventor: George N. Cox
  • Method to increase the number of circulating platelets by administering PEGylated cysteine variants of IL-11
    Patent number: 10329337
    Abstract: Disclosed are cysteine variants of interleukin-11 (IL-11) and methods of making and using such proteins in therapeutic applications.
    Type: Grant
    Filed: March 27, 2017
    Date of Patent: June 25, 2019
    Assignee: BOLDER BIOTECHNOLOGY, INC.
    Inventor: George N. Cox
  • METHODS AND USE OF GROWTH HORMONE SUPERGENE FAMILY PROTEIN ANALOGS FOR TREATMENT OF RADIATION EXPOSURE
    Publication number: 20180339021
    Abstract: Methods and compositions for the use of long-acting hematopoietic factor protein analogs for accelerating hematopoietic recovery in subjects who have been or will be exposed to radiation are disclosed.
    Type: Application
    Filed: June 4, 2018
    Publication date: November 29, 2018
    Inventors: George N. Cox, Christie M. Orschell
  • LONG ACTING PROTEINS AND PEPTIDES AND METHODS OF MAKING AND USING THE SAME
    Publication number: 20180334475
    Abstract: Disclosed is a method for refolding a protein or peptide that does not contain essential disulfides and that contains at least one free cysteine residue. Also disclosed are polymer IFN-? conjugates that have been created by the chemical coupling of polymers such as polyethylene glycol moieties to IFN-?, particularly via a free cysteine in the protein. Also disclosed are analogs of bioactive peptides that may be used to create longer acting versions of the peptides, including analogs of glucagon, glucagon-like peptide-1 (GLP-1), GLP-2, Gastric inhibitory peptide (GIP), PYY, exendin, ghrelin, gastrin, amylin, and oxyntomodulin.
    Type: Application
    Filed: November 17, 2017
    Publication date: November 22, 2018
    Inventors: George N. Cox, Mary S. Rosendahl
  • Methods and use of growth hormone supergene family protein analogs for treatment of radiation exposure
    Patent number: 10016485
    Abstract: Methods and compositions for the use of long-acting hematopoietic factor protein analogs for accelerating hematopoietic recovery in subjects who have been or will be exposed to radiation are disclosed.
    Type: Grant
    Filed: March 17, 2016
    Date of Patent: July 10, 2018
    Assignee: Bolder Biotechnology, Inc.
    Inventors: George N. Cox, Christie M. Orschell
  • CYSTEINE VARIANTS OF INTERLEUKIN-11 AND METHODS OF USE THEREOF
    Publication number: 20170369547
    Abstract: Disclosed are cysteine variants of interleukin-11 (IL-11) and methods of making and using such proteins in therapeutic applications.
    Type: Application
    Filed: March 27, 2017
    Publication date: December 28, 2017
    Inventor: George N. Cox
  • METHODS FOR MAKING PROTEINS CONTAINING FREE CYSTEINE RESIDUES
    Publication number: 20170362626
    Abstract: The present invention relates to novel methods of making soluble proteins having free cysteines in which a host cell is exposed to a cysteine blocking agent. The soluble proteins produced by the methods can then be modified to increase their effectiveness. Such modifications include attaching a PEG moiety to form pegylated proteins.
    Type: Application
    Filed: January 24, 2017
    Publication date: December 21, 2017
    Inventors: George N. Cox, Daniel H. Doherty, Mary S. Rosendahl
  • Methods of preparing cysteine variants of human recombinant IL-11
    Patent number: 9637530
    Abstract: Disclosed are cysteine variants of interleukin-11 (IL-11) and methods of making and using such proteins in therapeutic applications.
    Type: Grant
    Filed: April 25, 2014
    Date of Patent: May 2, 2017
    Assignee: Bolder Biotechnology, Inc.
    Inventor: George N. Cox, III
  • Hematopoitetic Growth Factor Proteins and Analogs Thereof and Angiotensin Converting Enzyme Inhibitors for Treatment of Radiation Exposure
    Publication number: 20170080055
    Abstract: Methods and compositions comprising hematopoietic growth factor proteins and/or protein analogs thereof and/or combinations thereof and angiotensin converting enzyme inhibitors to treat the acute and long term adverse effects of radiation exposure in subjects who have been or will be exposed to radiation are disclosed.
    Type: Application
    Filed: September 19, 2016
    Publication date: March 23, 2017
    Inventors: George N. Cox, Christie M. Orschell, Meetha Manek Medhora, Brian Fish
  • METHODS AND USE OF GROWTH HORMONE SUPERGENE FAMILY PROTEIN ANALOGS FOR TREATMENT OF RADIATION EXPOSURE
    Publication number: 20170035852
    Abstract: Methods and compositions for the use of long-acting hematopoietic factor protein analogs for accelerating hematopoietic recovery in subjects who have been or will be exposed to radiation are disclosed.
    Type: Application
    Filed: March 17, 2016
    Publication date: February 9, 2017
    Inventors: George N. Cox, Christie M. Orschell
  • LONG ACTING PROTEINS AND PEPTIDES AND METHODS OF MAKING AND USING THE SAME
    Publication number: 20170015701
    Abstract: Disclosed is a method for refolding a protein or peptide that does not contain essential disulfides and that contains at least one free cysteine residue. Also disclosed are polymer IFN-? conjugates that have been created by the chemical coupling of polymers such as polyethylene glycol moieties to IFN-?, particularly via a free cysteine in the protein. Also disclosed are analogs of bioactive peptides that may be used to create longer acting versions of the peptides, including analogs of glucagon, glucagon-like peptide-1 (GLP-1), GLP-2, Gastric inhibitory peptide (GIP), PYY, exendin, ghrelin, gastrin, amylin, and oxyntomodulin.
    Type: Application
    Filed: February 22, 2016
    Publication date: January 19, 2017
    Inventors: George N. Cox, Mary S. Rosendahl
  • METHODS FOR MAKING PROTEINS CONTAINING FREE CYSTEINE RESIDUES
    Publication number: 20160244798
    Abstract: The present invention relates to novel methods of making soluble proteins having free cysteines in which a host cell is exposed to a cysteine blocking agent. The soluble proteins produced by the methods can then be modified to increase their effectiveness. Such modifications include attaching a PEG moiety to form pegylated proteins.
    Type: Application
    Filed: January 15, 2015
    Publication date: August 25, 2016
    Inventors: George N. Cox, Daniel H. Doherty, Mary S. Rosendahl
  • CYSTEINE VARIANTS OF INTERLEUKIN-11 AND METHODS OF USE THEREOF
    Publication number: 20160200790
    Abstract: Disclosed are cysteine variants of interleukin-11 (IL-11) and methods of making and using such proteins in therapeutic applications.
    Type: Application
    Filed: April 25, 2014
    Publication date: July 14, 2016
    Applicant: BOLDER BIOTECHNOLOGY, INC.
    Inventor: George N. Cox, III
  • Methods and use of growth hormone supergene family protein analogs for treatment of radiation exposure
    Patent number: 9320777
    Abstract: Methods and compositions for the use of long-acting hematopoietic factor protein analogs for accelerating hematopoietic recovery in subjects who have been or will be exposed to radiation are disclosed.
    Type: Grant
    Filed: May 14, 2012
    Date of Patent: April 26, 2016
    Assignee: Bolder Biotechnology, Inc.
    Inventors: George N. Cox, Christie M. Orschell