Patents by Inventor George N. Rudenko
George N. Rudenko has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10557114Abstract: The invention features plant acyl-ACP thioesterase genes of the FatB class and proteins encoded by these genes. The genes are useful for constructing recombinant host cells having altered fatty acid profiles. Oleaginous microalga host cells with the new genes or previously identified FatB genes are disclosed. The microalgae cells produce triglycerides with useful fatty acid profiles.Type: GrantFiled: October 8, 2017Date of Patent: February 11, 2020Assignee: CORBION BIOTECH, INC.Inventors: George N. Rudenko, Jason Casolari, Scott Franklin
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Publication number: 20190194703Abstract: Novel plant acyl-ACP thioesterase genes of the FatB and FatA classes and proteins encoded by these genes are disclosed. The genes are useful for constructing recombinant host cells having altered fatty acid profiles. Expression of the novel and/or mutated FATB and FATA genes is demonstrated in oleaginous microalga host cells. Furthermore, a method for producing an oil elevated in one or more of C12:0, C14:0, C16:0, C18:0 and/or C18:1 fatty acids includes transforming a cell with novel and/or mutated FATB and/or FATA genes, e.g., having an N-terminal deletion. The cells produce triglycerides with altered and useful fatty acid profiles.Type: ApplicationFiled: November 9, 2018Publication date: June 27, 2019Inventors: Jason Casolari, George N. Rudenko, Scott Franklin, Xinhua Zhao
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Patent number: 10316299Abstract: The present invention relates to beta-ketoacyl ACP synthase genes of the KASI/KASIV type and proteins encoded by these genes. The genes can be included in nucleic acid constructs, vectors or host cells. Expression of the gene products can alter the fatty acid profile of host cells. The KAS genes can be combined with a FATA or FATB thioesterase gene to create a cell that produces an increased amount of C8-C16 fatty acids. Suitable host cells include plastidic cells of plants or microalgae. Oleaginous microalga host cells with the new genes are disclosed.Type: GrantFiled: April 10, 2018Date of Patent: June 11, 2019Assignee: CORBION BIOTECH, INC.Inventors: David Davis, George N. Rudenko, Aravind Somanchi, Jason Casolari, Scott Franklin, Aren Ewing
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Patent number: 10287613Abstract: Recombinant DNA techniques are used to produce oleaginous recombinant cells that produce triglyceride oils having desired fatty acid profiles and regiospecific or stereospecific profiles. Genes manipulated include those encoding stearoyl-ACP desturase, delta 12 fatty acid desaturase, acyl-ACP thioesterase, ketoacyl-ACP synthase, and lysophosphatidic acid acyltransferase. The oil produced can have enhanced oxidative or thermal stability, or can be useful as a frying oil, shortening, roll-in shortening, tempering fat, cocoa butter replacement, as a lubricant, or as a feedstock for various chemical processes. The fatty acid profile can be enriched in midchain profiles or the oil can be enriched in triglycerides of the saturated-unsaturated-saturated type.Type: GrantFiled: January 19, 2018Date of Patent: May 14, 2019Assignee: CORBION BIOTECH, INC.Inventors: Scott Franklin, Aravind Somanchi, George N. Rudenko, Riyaz Bhat, Xinhua Zhao, Risha Bond, Walter Rakitsky, Alejandro Marangoni, Diza Braksmayer
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Patent number: 10260076Abstract: Disclosed herein are methods of manufacturing renewable chemicals through the manufacture of novel triglyceride oils followed by chemical modification of the oils. Methods such as transesterification, hydrogenation, hydrocracking, deoxygenation, isomerization, interesterification, hydroxylation, hydrolysis and saponification are disclosed. Novel oils containing fatty acid chain lengths of C8, C10, C12 or C14 are also disclosed and are useful as feedstocks in the methods of the invention.Type: GrantFiled: February 27, 2017Date of Patent: April 16, 2019Assignee: CORBION BIOTECH, INC.Inventors: Scott Franklin, Aravind Somanchi, Karen Espina, George N. Rudenko, Penelope Chua
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Patent number: 10125382Abstract: Novel plant acyl-ACP thioesterase genes of the FatB and FatA classes and proteins encoded by these genes are disclosed. The genes are useful for constructing recombinant host cells having altered fatty acid profiles. Expression of the novel and/or mutated FATB and FATA genes is demonstrated in oleaginous microalga host cells. Furthermore, a method for producing an oil elevated in one or more of C12:0, C14:0, C16:0, C18:0 and/or C18:1 fatty acids includes transforming a cell with novel and/or mutated FATB and/or FATA genes, e.g., having an N-terminal deletion. The cells produce triglycerides with altered and useful fatty acid profiles.Type: GrantFiled: September 18, 2015Date of Patent: November 13, 2018Assignee: CORBION BIOTECH, INC.Inventors: Jason Casolari, George N. Rudenko, Scott Franklin, Xinhua Zhao
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Publication number: 20180237811Abstract: Recombinant DNA techniques are used to produce oleaginous recombinant cells that produce triglyceride oils having desired fatty acid profiles and regiospecific or stereospecific profiles. Genes manipulated include those encoding stearoyl-ACP desturase, delta 12 fatty acid desaturase, acyl-ACP thioesterase, ketoacyl-ACP synthase, and lysophosphatidic acid acyltransferase. The oil produced can have enhanced oxidative or thermal stability, or can be useful as a frying oil, shortening, roll-in shortening, tempering fat, cocoa butter replacement, as a lubricant, or as a feedstock for various chemical processes. The fatty acid profile can be enriched in midchain profiles or the oil can be enriched in triglycerides of the saturated-unsatturated-saturated type.Type: ApplicationFiled: January 19, 2018Publication date: August 23, 2018Applicants: Corbion Biotech, Inc., Corbion Biotech, Inc.Inventors: Scott Franklin, Aravind Somanchi, George N. Rudenko, Riyaz Bhat, Xinhua Zhao, Risha Bond, Walter Rakitsky, Alejandro Marangoni, Diza Braksmayer
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Publication number: 20180230442Abstract: The present invention relates to beta-ketoacyl ACP synthase genes of the KASI/KASIV type and proteins encoded by these genes. The genes can be included in nucleic acid constructs, vectors or host cells. Expression of the gene products can alter the fatty acid profile of host cells. The KAS genes can be combined with a FATA or FATB thioesterase gene to create a cell that produces an increased amount of C8-C16 fatty acids. Suitable host cells include plastidic cells of plants or microalgae. Oleaginous microalga host cells with the new genes are disclosed.Type: ApplicationFiled: April 10, 2018Publication date: August 16, 2018Inventors: David Davis, George N. Rudenko, Aravind Somanchi, Jason Casolari, Scott Franklin, Aren Ewing
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Publication number: 20180208953Abstract: The invention features plant acyl-ACP thioesterase genes of the FatB class and proteins encoded by these genes. The genes are useful for constructing recombinant host cells having altered fatty acid profiles. Oleaginous microalga host cells with the new genes or previously identified FatB genes are disclosed. The microalgae cells produce triglycerides with useful fatty acid profiles.Type: ApplicationFiled: October 8, 2017Publication date: July 26, 2018Applicant: TerraVia Holdings, Inc.Inventors: George N. Rudenko, Jason Casolari, Scott Franklin
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Publication number: 20170314048Abstract: Disclosed herein are methods of manufacturing renewable chemicals through the manufacture of novel triglyceride oils followed by chemical modification of the oils. Methods such as transesterification, hydrogenation, hydrocracking, deoxygenation, isomerization, interesterification, hydroxylation, hydrolysis and saponification are disclosed. Novel oils containing fatty acid chain lengths of C8, C10, C12 or C14 are also disclosed and are useful as feedstocks in the methods of the invention.Type: ApplicationFiled: February 27, 2017Publication date: November 2, 2017Inventors: Scott Franklin, Aravind Somanchi, Karen Espina, George N. Rudenko, Penelope Chua
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Patent number: 9783836Abstract: The invention features plant acyl-ACP thioesterase genes of the FatB class and proteins encoded by these genes. The genes are useful for constructing recombinant host cells having altered fatty acid profiles. Oleaginous microalga host cells with the new genes or previously identified FatB genes are disclosed. The microalgae cells produce triglycerides with useful fatty acid profiles.Type: GrantFiled: March 13, 2014Date of Patent: October 10, 2017Assignee: TERRAVIA HOLDINGS, INC.Inventors: George N. Rudenko, Jason Casolari, Scott Franklin
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Patent number: 9649368Abstract: Genetically engineered microbial, e.g., Prototheca, cells provide microbial oil useful as a food additive and a source of renewable fuels and industrial chemicals.Type: GrantFiled: April 5, 2016Date of Patent: May 16, 2017Assignee: TERRAVIA HOLDINGS, INC.Inventors: Scott Franklin, Shane Brubaker, George N. Rudenko, Jeffrey L. Moseley, Xinhua Zhao, Tina T. Huynh, Riyaz Bhat, Matthew Shoa-Azar, Trung H. Nguyen, Karen Espina, Aravind Somanchi
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Patent number: 9518277Abstract: Genetically engineered microbial, e.g., Chlorella protothecoides, cells producing microbial oils are useful as a food additive and a source of renewable fuels and industrial chemicals. Lipid biosynthesis genes for Auxenochlorella protethecoides are disclosed that are useful for increasing lipid production and altering fatty acid and triacylglycerol profiles in recombinant microrganisms including cells of the genus Auxenochlorella or Prototheca.Type: GrantFiled: December 6, 2013Date of Patent: December 13, 2016Assignee: TerraVia Holdings, Inc.Inventors: Scott Franklin, Shane Brubaker, George N. Rudenko, Riyaz Bhat, Matthew Shoa-Azar, Aravind Somanchi, Aren Ewing
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Publication number: 20160289695Abstract: Genetically engineered microbial, e.g., Prototheca, cells provide microbial oil useful as a food additive and a source of renewable fuels and industrial chemicals.Type: ApplicationFiled: April 5, 2016Publication date: October 6, 2016Inventors: Scott FRANKLIN, Shane BRUBAKER, George N. RUDENKO, Jeffrey L. MOSELEY, Xinhua ZHAO, Tina T. HUYNH, Riyaz BHAT, Matthew SHOA-AZAR, Trung H. NGUYEN, Karen ESPINA, Aravind SOMANCHI
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Publication number: 20160251685Abstract: The invention features plant acyl-ACP thioesterase genes of the FatB class and proteins encoded by these genes. The genes are useful for constructing recombinant host cells having altered fatty acid profiles. Oleaginous microalga host cells with the new genes or previously identified FatB genes are disclosed. The microalgae cells produce triglycerides with useful fatty acid profiles.Type: ApplicationFiled: March 5, 2016Publication date: September 1, 2016Applicant: Solazyme, Inc.Inventors: George N. RUDENKO, Jason CASOLARI, Scott FRANKLIN
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Patent number: 9328351Abstract: Genetically engineered microbial, e.g., Prototheca, cells provide microbial oil useful as a food additive and a source of renewable fuels and industrial chemicals.Type: GrantFiled: November 28, 2012Date of Patent: May 3, 2016Assignee: SOLAZYME, INC.Inventors: Scott Franklin, Shane Brubaker, George N. Rudenko, Jeffrey L. Moseley, Xinhua Zhao, Tina T. Huynh, Riyaz Bhat, Matthew Shoa-Azar, Trung H. Nguyen, Karen Espina, Aravind Somanchi
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Publication number: 20160083758Abstract: Novel plant acyl-ACP thioesterase genes of the FatB and FatA classes and proteins encoded by these genes are disclosed. The genes are useful for constructing recombinant host cells having altered fatty acid profiles. Expression of the novel and/or mutated FATB and FATA genes is demonstrated in oleaginous microalga host cells. Furthermore, a method for producing an oil elevated in one or more of C12:0, C14:0, C16:0, C18:0 and/or C18:1 fatty acids includes transforming a cell with novel and/or mutated FATB and/or FATA genes, e.g., having an N-terminal deletion. The cells produce triglycerides with altered and useful fatty acid profiles.Type: ApplicationFiled: September 18, 2015Publication date: March 24, 2016Applicant: Solazyme, Inc.Inventors: Jason CASOLARI, George N. RUDENKO, Scott FRANKLIN, Xinhua ZHAO
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Patent number: 9290749Abstract: The invention features plant acyl-ACP thioesterase genes of the FatB class and proteins encoded by these genes. The genes are useful for constructing recombinant host cells having altered fatty acid profiles. Oleaginous microalga host cells with the new genes or previously identified FatB genes are disclosed. The microalgae cells produce triglycerides with useful fatty acid profiles.Type: GrantFiled: March 15, 2013Date of Patent: March 22, 2016Assignee: Solazyme, Inc.Inventors: George N. Rudenko, Jason Casolari, Scott Franklin
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Publication number: 20140288320Abstract: The invention features plant acyl-ACP thioesterase genes of the FatB class and proteins encoded by these genes. The genes are useful for constructing recombinant host cells having altered fatty acid profiles. Oleaginous microalga host cells with the new genes or previously identified FatB genes are disclosed. The microalgae cells produce triglycerides with useful fatty acid profiles.Type: ApplicationFiled: March 13, 2014Publication date: September 25, 2014Applicant: Solazyme, Inc.Inventors: George N. Rudenko, Jason Casolari, Scott Franklin
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Publication number: 20140275586Abstract: The invention features plant acyl-ACP thioesterase genes of the FatB class and proteins encoded by these genes. The genes are useful for constructing recombinant host cells having altered fatty acid profiles. Oleaginous microalga host cells with the new genes or previously identified FatB genes are disclosed. The microalgae cells produce triglycerides with useful fatty acid profiles.Type: ApplicationFiled: March 15, 2013Publication date: September 18, 2014Inventors: George N. Rudenko, Jason Casolari, Scott Franklin