Patents by Inventor George NACLERIO

George NACLERIO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BENZAMIDE ANTIBACTERIAL AGENTS
    Publication number: 20230391767
    Abstract: The present invention generally relates to compounds as a new antibiotic to treat various infections, including infections caused by methicillin-resistant Staphylococcus aureus, vancomycin-intermediate and vancomycin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecalis and Clostridioides difficile. Pharmaceutical compositions and methods for treating those diseases are within the scope of this invention.
    Type: Application
    Filed: August 21, 2023
    Publication date: December 7, 2023
    Inventors: Herman O. SINTIM, Mohamed SELEEM, Clement OPOKU-TEMENG, Haroon Taj MOHAMMAD, George NACLERIO
  • Benzamide antibacterial agents
    Patent number: 11731964
    Abstract: The present invention generally relates to compounds as a new antibiotic to treat various infections, including infections caused by methicillin-resistant Staphylococcus aureus, vancomycin-intermediate and vancomycin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecalis and Clostridioides difficile. Pharmaceutical compositions and methods for treating those diseases are within the scope of this invention.
    Type: Grant
    Filed: March 29, 2019
    Date of Patent: August 22, 2023
    Assignee: Purdue Research Foundation
    Inventors: Herman O. Sintim, Mohamed Seleem, Clement Opoku-Temeng, Haroon Taj Mohammad, George Naclerio
  • CF3-, OCF3-, SCF3-, and SF5-Containing Antibacterial Agents
    Publication number: 20220249447
    Abstract: The present invention generally relates to compounds as a new antibiotic to treat various infections, including infections caused by methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-intermediate and vancomycin-resistant S. aureus (VISA and VRSA respectively) vancomycin-resistant Enterococcusfaecalis (VRE), and Clostridioides difficile. Pharmaceutical compositions and methods for treating those infection diseases are within the scope of this invention.
    Type: Application
    Filed: April 24, 2020
    Publication date: August 11, 2022
    Inventors: Herman O. Sintim, George Naclerio
  • INHIBITORS OF CYCLIC MONO- AND DI-NUCLEOTIDE PHOSPHODIESTERASES AND THE USES THEREOF
    Publication number: 20220194957
    Abstract: Cyclic nucleotides, both mono- and di-nucleotides, play diverse roles in the prokaryotes and eukaryotes. Described are compounds, which inhibit phosphodiesterases that inhibit cyclic mononucleotide or dinucleotides and/or both mononucleotide and dinucleotide. These compounds have potential diverse applications as antiviral, antibacterial, anti-inflammatory and anticancer agents, including cancer immunotherapy. Pharmaceutical compositions and methods for treating those kinase related diseases are within the scope of this invention.
    Type: Application
    Filed: December 16, 2021
    Publication date: June 23, 2022
    Applicant: Purdue Research Foundation
    Inventors: Herman O. Sintim, George Naclerio, Caroline Karanja
  • BENZAMIDE ANTIBACTERIAL AGENTS
    Publication number: 20210047316
    Abstract: The present invention generally relates to compounds as a new antibiotic to treat various infections, including infections caused by methicillin-resistant Staphylococcus aureus, vancomycin-intermediate and vancomycin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecalis and Clostridioides difficile. Pharmaceutical compositions and methods for treating those diseases are within the scope of this invention.
    Type: Application
    Filed: March 29, 2019
    Publication date: February 18, 2021
    Inventors: Herman O. SINTIM, Mohamed SELEEM, Clement OPOKU-TEMENG, Haroon Taj MOHAMMAD, George NACLERIO