Abstract: A closure member is configured for use in a valve. These configurations may include a plug with grooves or “flutes” that extend along its length. Inserts in the flutes may comprise materials, like ceramics, that are different than the material that forms the core or base portion of the plug. These inserts are useful to slow erosion of the device, particularly in the flutes, which form an outwardly-facing surface that is subject to high velocity flow in the valve. This feature can extend service life of the plug, particularly in highly-erosive process fluids, like particle-entrained fluids commonly found in hydrocracking or refining operations.

Abstract: Disclosed herein include methods, compositions, and kits suitable for use in treatment and/or prevention of RNA viral infections. In some embodiments, the method comprises modulation of host factors related to RNA viral infection using compounds, compositions and kits disclosed herein. There are provided, some embodiments, compounds modulating host factors that govern SARS-CoV-2 replication. Disclosed herein include the use of compounds, compositions and kits disclosed herein to prevent and/or treat SARS-CoV-2 infection, for example by modulating the SARS-CoV-2 life cycle.

Abstract: Compounds, pharmaceutically acceptable salts, and pharmaceutical compositions thereof are disclosed that are useful for inhibition of the biological activity of CCL2, as well as methods of treatment for diseases involving the biological activity of CCL2.

Abstract: Methods and compositions for treating RNA viral infections, including behavior symptoms of the RNA viral infections, are disclosed herein. Also disclosed are methods and compositions for reducing the progression of clinical complications associated with RNA viral infections. The methods, for example, can include administering pharmaceutical compositions or analogues thereof to a patient in need. One or more additional therapeutic agents can also be administered to the patient in the disclosed methods.

Abstract: Compounds, pharmaceutically acceptable salts, and pharmaceutical compositions thereof are disclosed that are useful for inhibition of the biological activity of CCL2, as well as methods of treatment for diseases involving the biological activity of CCL2.

Abstract: Compounds, pharmaceutically acceptable salts, and pharmaceutical compositions thereof are disclosed that are useful for inhibition of the biological activity of CCL2, as well as methods of treatment for diseases involving the biological activity of CCL2.

Abstract: An assembly includes a main terminal equipped with a communication module using at least a first communications protocol capable of connecting the main terminal to a communication network, which enables the use of at least one function, the main terminal being arranged to use at least one configuration program, and the configuration program enables at least one preferred function to be selected and a code representing the selected preferred function to be generated, and a second communications protocol. The assembly additionally comprises at least one secondary terminal equipped with a passive communication module using the second communications protocol to communicate with the main terminal in order to protect the code representing the selected preferred function.

Abstract: Compounds, pharmaceutically acceptable salts, and pharmaceutical compositions thereof are disclosed that are useful for inhibition of the biological activity of CCL2, as well as methods of treatment for diseases involving the biological activity of CCL2.

Abstract: Compounds, pharmaceutically acceptable salts, and pharmaceutical compositions thereof are disclosed that are useful for inhibition of the biological activity of HMGB1, as well as methods of treatment for diseases involving the inflammation activity or cytokine activity of HMGB1.

Abstract: A set of devices including: at least one receiver and at least one portable device, the receiver including a mechanism receiving a multichannel signal capable of preserving a part of the signal transmitted on a particular channel allowing information to be received, a conversion mechanism associated with a propagation mechanism broadcasting the information, and a communication mechanism; a portable object including an electronic module, the electronic module including at least a calculation unit and a wireless communication circuit to communicate with the communication mechanism of the receiver. The portable object can detect, via the wireless communication circuit, presence of at least one receiver belonging to the set of devices and acting on the at least one receiver to change the particular channel and to select a particular channel whose identifier or whose program currently being broadcast has at least one identifier identical to the identifier programmed in the portable object.

Abstract: An assembly includes a main terminal equipped with a communication module using at least a first communications protocol capable of connecting the main terminal to a communication network, which enables the use of at least one function, the main terminal being arranged to use at least one configuration program, and the configuration program enables at least one preferred function to be selected and a code representing the selected preferred function to be generated, and a second communications protocol. The assembly additionally comprises at least one secondary terminal equipped with a passive communication module using the second communications protocol to communicate with the main terminal in order to protect the code representing the selected preferred function.

Abstract: A set of devices including: at least one receiver and at least one portable device, the receiver including a mechanism receiving a multichannel signal capable of preserving a part of the signal transmitted on a particular channel allowing information to be received, a conversion mechanism associated with a propagation mechanism broadcasting the information, and a communication mechanism; a portable object including an electronic module, the electronic module including at least a calculation unit and a wireless communication circuit to communicate with the communication mechanism of the receiver. The portable object can detect, via the wireless communication circuit, presence of at least one receiver belonging to the set of devices and acting on the at least one receiver to change the particular channel and to select a particular channel whose identifier or whose program currently being broadcast has at least one identifier identical to the identifier programmed in the portable object.

Abstract: There is disclosed a method and a system for accessing information and/or data available on a wide area computer network (100), such as the Internet. A first modulated acoustic signal (A) is transmitted to a group of potential users each provided with a portable communication unit (1, 1*), this first modulated acoustic signal including at least one identifier (ID—1, ID—2, ID—3, . . . ) associated with a link to a determined site of the wide area computer network. These identifiers are stored in the portable communication unit then subsequently downloaded to a computer terminal (50, 51, 52) connected to the wide area computer network. After the downloaded identifier or identifiers have been compared with a determined list of identifiers (ID_A, ID_B, ID_C, . . . ), a list of links (Link_A, Link_B, Link_C, . . . ) to sites corresponding to the downloaded identifier or identifiers is generated by the computer terminal.

Abstract: There is disclosed a method and a system for accessing information and/or data available on a wide area computer network (100), such as the Internet. A first modulated acoustic signal (A) is transmitted to a group of potential users each provided with a portable communication unit (1, 1*), this first modulated acoustic signal including at least one identifier (ID—1, ID—2, ID—3, . . . ) associated with a link to a determined site of the wide area computer network. These identifiers are stored in the portable communication unit then subsequently downloaded to a computer terminal (50, 51, 52) connected to the wide area computer network. After the downloaded identifier or identifiers have been compared with a determined list of identifiers (ID_A, ID_B, ID_C, . . . ), a list of links (Link_A, Link_B, Link_C, . . . ) to sites corresponding to the downloaded identifier or identifiers is generated by the computer terminal.

Abstract: There is disclosed a method and a system for accessing information and/or data available on a wide area computer network (100), such as the Internet. A first modulated acoustic signal (A) is transmitted to a group of potential users each provided with a portable communication unit (1, 1*), this first modulated acoustic signal including at least one identifier (ID—1, ID—2, ID—3, . . . ) associated with a link to a determined site of the wide area computer network. These identifiers are stored in the portable communication unit then subsequently downloaded to a computer terminal (50, 51, 52) connected to the wide area computer network. After the downloaded identifier or identifiers have been compared with a determined list of identifiers (ID_A, ID_B, ID_C, . . . ), a list of links (Link_A, Link_B, Link_C, . . . ) to sites corresponding to the downloaded identifier or identifiers is generated by the computer terminal.

Abstract: There is disclosed a method and a system for accessing information and/or data available on a wide area computer network (100), such as the Internet. A first modulated acoustic signal (A) is transmitted to a group of potential users each provided with a portable communication unit (1, 1*), this first modulated acoustic signal including at least one identifier (ID—1, ID—2, ID—3, . . . ) associated with a link to a determined site of the wide area computer network. These identifiers are stored in the portable communication unit then subsequently downloaded to a computer terminal (50, 51, 52) connected to the wide area computer network. After the downloaded identifier or identifiers have been compared with a determined list of identifiers (ID_A, ID_B, ID_C, . . . ), a list of links (Link_A, Link_B, Link_C, . . . ) to sites corresponding to the downloaded identifier or identifiers is generated by the computer terminal.

Abstract: This watch can guide its wearer towards a place specified by the wearer and comprises time display means (2, 3, 11), selection means (9), data processing means (8) and means for determining the direction of the said place, formed by an antenna (5) and a GPS receiver (6) for determining the geographical coordinates of the location where the said watch is situated. According to the invention this watch further comprises an electronic tourist guide comprising a re-programmable memory unit (14) arranged to receive a database relative to local tourist information, the said selection means (9) being so arranged that the wearer can select the said place in the said database, and that the said means for determining the direction can determine the said direction of the said place and can then indicate this direction by way of the said display means (2, 3, 11).

Abstract: This invention relates to the detection of biomolecules. Specifically, the invention relates to electronic or electrochemical detection of biomolecules using biochip arrays. In particular, the invention provides an apparatus comprising a platform for a column-and-row addressable, high-density, enhanced-sensitivity biochip array, and methods of use thereof. The devices and methods of the invention can be used to detect molecular interactions such as nucleic acid hybridization or protein binding.