Patents by Inventor George P. Beardsley

George P. Beardsley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrido[2,3-]pyrimidine derivatives
    Patent number: 5026851
    Abstract: 2,4-Diamino- and 2-amino-4-hydroxy- derivatives of N-(4-[2-(pyrido[2,3-d]pyrimidin-6-yl)alkyl]benzoyl-)-L-glutamic acids, and the corresponding 5,6,7,8-tetrahydro compounds are antineoplastic agents.The compounds are prepared by hydrolytic or hydrogenolytic removal of carboxylic acid protecting groups from the correspondingly protected glutamic acid derivatives.A typical embodiment is N-(4-[2-(2-amino-4-hydroxy-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-yl)e thyl]benzoyl)-L-glutamic acid.
    Type: Grant
    Filed: April 21, 1989
    Date of Patent: June 25, 1991
    Assignee: The Trustees of Princeton University
    Inventors: Edward C. Taylor, George P. Beardsley, Peter J. Harrington, Stephen R. Fletcher
  • Diastereoisomeric tetrahydropyrido-(2,3,d) pyrimidine derivatives
    Patent number: 4927828
    Abstract: The diastereoisomeric forms of N-(4-[2-(2-amino-4-hydroxy-5,6,7,8-tetrahydropyrido[2,3-d]-pyrimidin-6-yl) ethyl]benzoyl)-L-glutamic acid are antineoplastic agents.The compounds are prepared by separation of the diastereoisomeric form of the correspondingly protected glutamic derivatives and hydrolytic or hydrogenolytic removal of carboxylic acid and/or amino protecting groups.Typical embodiments are the (R,S) and (S,S) forms of N-(4-[2-(2-amino-4-hydroxy-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-yl)e thyl]benzoyl)-L-glutamic acid.
    Type: Grant
    Filed: June 28, 1988
    Date of Patent: May 22, 1990
    Assignee: The Trustees of Princeton University
    Inventors: Edward C. Taylor, George P. Beardsley, Chuan Shih, Stephen R. Fletcher
  • Pyrido [2,3,d]pyrimidine derivatives
    Patent number: 4845216
    Abstract: 2,4-Diamino- and 2-amino-4-hydroxy- derivatives of N-(4-[2-(pyrido[2,3-d]pyrimidin-6-yl)alkyl]benzoyl)-L-glutamic acids, and the corresponding 5,6,7,8-tetrahydro compounds are antineoplastic agents. The compounds are prepared by hydrolytic or hydrogenolytic removal of carboxylic acid protecting groups from the correspondingly protected glutamic acid derivatives. A typical embodiment is N-)4-[2-(2-amino-4-hydroxy-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-yl)e thyl]benzoyl)-L-glutamic acid.
    Type: Grant
    Filed: July 17, 1987
    Date of Patent: July 4, 1989
    Assignee: The Trustees of Princeton University
    Inventors: Edward C. Taylor, George P. Beardsley, Peter J. Harrington, Stephen R. Fletcher
  • 4(3H)-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidine derivatives
    Patent number: 4833145
    Abstract: Derivatives of N-[4-(N-[2-amino-4(3H)-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-ylme thyl]-amino)benzoyl]-L-glutamic acid are antineoplastic agents. Their preparation and use, and intermediates useful for their preparation are described.
    Type: Grant
    Filed: November 13, 1987
    Date of Patent: May 23, 1989
    Assignees: The Trustees of Princeton University, Eli Lilly and Company
    Inventors: Edward C. Taylor, George P. Beardsley, Chuan Shih
  • 4 (3H)-oxo-5,6,7,8-tetrahydropyrido-(2,3-d)pyrimidine derivatives
    Patent number: 4831037
    Abstract: N-[4-(N'-[2-amino-4(3H)-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-ylme thyl]-N'-acylamino)benzoyl]-L-glutamic acid derivatives are antineoplastic agents. The compounds are prepared through acylation of the corresponding N'-amino compound or hydrolysis of a protected N'-acylamino compound. A typical embodiment is N-[4-(N'-[2-amino-4(3H)-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-ylm ethyl]-N'-formylamino)benzoyl]-L-glutamic acid.
    Type: Grant
    Filed: April 20, 1987
    Date of Patent: May 16, 1989
    Assignee: The Trustees of Princeton University
    Inventors: Edward C. Taylor, George P. Beardsley, James M. Hamby
  • Pyrido(2,3-d)pyrimidine derivatives
    Patent number: 4684653
    Abstract: 2,4-Diamino- and 2-amino-4-hydroxy- derivatives of N-(4-[1-(pyrido[2,3-d]pyrimidin-6-yl)alk-2-yl]-benzoyl)-L-glutamic acids, and the corresponding 5,6,7,8-tetrahydro compounds are antineoplastic agents.The compounds are prepared by hydrolytic or hydrogenolytic removal of carboxylic acid protecting groups from the correspondingly protected glutamic acid derivatives.A typical embodiment is N-(4-[2-(2-amino-4-hydroxy-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-yl)e thyl]benzoyl)-L-glutamic acid.
    Type: Grant
    Filed: March 3, 1986
    Date of Patent: August 4, 1987
    Assignee: The Trustees of Princeton University
    Inventors: Edward C. Taylor, George P. Beardsley, Peter J. Harrington, Stephen R. Fletcher