Patents by Inventor George P. Claxton

George P. Claxton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing quinoline aldehyde and ketone derivatives
    Patent number: 4999431
    Abstract: This invention relates to novel quinolyloxazole-2-ones which are useful as protein kinase C inhibitors, effective in the treatment of hypertension and asthma. This invention also includes a novel procedure for producing an intermediate ketone compound involving the reaction of a bromo-quinoline compound with butyl lithium and further reacting the lithiated compound with N-methyl-N-methoxyalkanamide.
    Type: Grant
    Filed: February 23, 1990
    Date of Patent: March 12, 1991
    Assignee: Merrell Dow Pharmaceuticals
    Inventors: Winton D. Jones, Richard C. Dage, George P. Claxton, Hsien C. Cheng, Phillip J. Robinson
  • Method of using quinolyloxazole-2-ones as proteinkinase C inhibitors
    Patent number: 4990519
    Abstract: This invention relates to novel quinolyloxazole-2-ones which are useful as protein kinase C inhibitors, effective in the treatment of hypertension and asthma. This invention also includes a novel procedure for producing an intermediate ketone compound involving the reaction of a bromo-quinoline compound with butyl lithium and further reacting the lithiated compound with N-methyl-N-methoxyalkanamide.
    Type: Grant
    Filed: February 23, 1990
    Date of Patent: February 5, 1991
    Assignee: Merrell Dow Pharmaceuticals
    Inventors: Winton D. Jones, George P. Claxton, Richard C. Dage, Hsien C. Cheng, Phillip J. Robinson
  • Qunolyloxazole-2-ones useful as proteinkinase C inhibitors
    Patent number: 4886811
    Abstract: This invention relates to novel quinolyloxazole-2-ones which are useful as protein kinase C inhibitors, effective in the treatment of hypertension and asthma. This invention also includes a novel procedure for producing an intermediate ketone compound involving the reaction of a bromo-quinoline compound with butyl lithium and further reacting the lithiated compound with N-methyl-N-methoxyalkanamide.
    Type: Grant
    Filed: October 24, 1988
    Date of Patent: December 12, 1989
    Assignee: Merrell Dow Pharmaceuticals
    Inventors: Winton D. Jones, George P. Claxton, Richard C. Dage, Hsien C. Cheng, Phillip J. Robinson
  • Cardiotonic phenyl oxazolones
    Patent number: 4866085
    Abstract: Phenyloxazolones are useful as cardiotonics in the treatment of heart failure and enhance cardiac function.
    Type: Grant
    Filed: November 24, 1987
    Date of Patent: September 12, 1989
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Richard A. Schnettler, George P. Claxton, Winton D. Jones, Jr.
  • Cardiotonic tricyclic oxazolones
    Patent number: 4803210
    Abstract: Tricyclic oxazolones enhance myocardial contractile force and are useful as cardiotonics in the treatment of heart failure.
    Type: Grant
    Filed: April 14, 1988
    Date of Patent: February 7, 1989
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Winton D. Jones, Richard A. Schnettler, George P. Claxton, Richard C. Dage
  • Cardiotonic tricyclic imidazolones
    Patent number: 4743607
    Abstract: Tricyclic imidazolones enhance myocardial contractile force and are useful as cardiotonics in the treatment of heart failure.
    Type: Grant
    Filed: May 29, 1987
    Date of Patent: May 10, 1988
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Winton D. Jones, George P. Claxton, Richard A. Schnettler, Richard C. Dage
  • Cardiotonic phenyl oxazolones
    Patent number: 4728661
    Abstract: Phenyloxazolones are useful as cardiotonics in the treatment of heart failure and enhance cardiac function.
    Type: Grant
    Filed: November 13, 1985
    Date of Patent: March 1, 1988
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Richard A. Schnettler, Winton D. Jones, Jr., George P. Claxton
  • Cardiotonic heterocyclic oxazolones
    Patent number: 4698353
    Abstract: Heterocyclic oxazolones enhance myocardial contractile force and cardiac function and are used as cardiotonics in the treatment of heart failure.
    Type: Grant
    Filed: November 13, 1985
    Date of Patent: October 6, 1987
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Richard A. Schnettler, Winton D. Jones, Jr., George P. Claxton
  • Cardiotonic thiazolones
    Patent number: 4670450
    Abstract: Thiazolones enhance myocardial contractile force and are useful as cardiotonics in the treatment of heart failure.
    Type: Grant
    Filed: November 13, 1985
    Date of Patent: June 2, 1987
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Richard A. Schenttler, Winton D. Jones, Jr., George P. Claxton
  • 2-Hydroxy-5-(1-hydroxy-2-piperazinylethyl)-benzoic acid derivatives
    Patent number: 4255575
    Abstract: Derivatives of 2-hydroxy-5-(1-hydroxy-2-piperazinylethyl)benzoic acid are prepared which are useful for their blocking action on .alpha. and .beta.-adrenergic receptors. In addition, these compounds are useful as spasmolytic and antihypertensive agents.
    Type: Grant
    Filed: May 4, 1979
    Date of Patent: March 10, 1981
    Assignee: Richardson-Merrell Inc.
    Inventors: J. Martin Grisar, George P. Claxton
  • 2-Hydro xy-5-[1-hydroxy-2-[4-(2-oxo-1-benzimidazolinyl)piperidino]ethyl]benzoic acid derivatives
    Patent number: 4200755
    Abstract: Derivatives of 2-hydroxy-5-[1-hydroxy-2-[4-(2-oxo-1-benzimidazolinyl)piperidino]ethyl]ben zoic acid are prepared which are useful for their blocking action on .alpha. and .beta.-adrenergic receptors. In addition, these compounds are useful for their spasmolytic and anti-hypertensive activity.
    Type: Grant
    Filed: May 4, 1979
    Date of Patent: April 29, 1980
    Assignee: Richardson-Merrell Inc.
    Inventors: J. Martin Grisar, George P. Claxton
  • .alpha.-Alkylbenzyl lactamimides
    Patent number: 4055561
    Abstract: Novel derivatives of .alpha.-alkylbenzyl lactamimide are useful as anticoagulants.
    Type: Grant
    Filed: April 25, 1973
    Date of Patent: October 25, 1977
    Assignee: Richardson-Merrell Inc.
    Inventors: J. Martin Grisar, George P. Claxton, Robert D. MacKenzie
  • N-(phenylether-substituted benzyl)alkanediamines
    Patent number: 4038412
    Abstract: Novel N-(substituted benzyl)alkanediamines are prepared which are useful for the prevention and inhibition of viral infections.
    Type: Grant
    Filed: August 25, 1975
    Date of Patent: July 26, 1977
    Assignee: Richardson-Merrell Inc.
    Inventors: J. Martin Grisar, George P. Claxton
  • Process for preparing 2-azacycloalkylmethyl ketones
    Patent number: 3931155
    Abstract: A process for the preparation of 2-azacycloalkylmethyl ketones by chelating a methyl ketone with magnesium methyl carbonate and condensing the chelate with a 1-azacycloalkene in an atmosphere of carbon dioxide. The novel compounds described are useful anticoagulants.
    Type: Grant
    Filed: April 25, 1973
    Date of Patent: January 6, 1976
    Assignee: Richardson-Merrell Inc.
    Inventors: J. Martin Grisar, George P. Claxton