Patents by Inventor George P. Hess

George P. Hess has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • THERAPEUTIC TREATMENT FOR DRUG POISONING AND ADDICTION
    Publication number: 20160193202
    Abstract: The present invention relates to methods of treating or preventing drug poisoning and drug addiction in a subject. These methods involve administering to a subject in need of said treatment or prevention a ligand which binds to a regulatory site on the nicotinic acetylcholine receptor.
    Type: Application
    Filed: August 12, 2014
    Publication date: July 7, 2016
    Inventors: Stephen H. CURRY, George P. HESS
  • Inhibition of beta-amyloid peptide aggregation
    Patent number: 9233106
    Abstract: The present invention relates to methods of using cocaine-binding-site ligands and cocaine-binding-site RNA aptamers to treat or prevent Alzheimer's Disease and to reduce or prevent aggregation of beta-amyloid peptides in a subject.
    Type: Grant
    Filed: July 12, 2007
    Date of Patent: January 12, 2016
    Assignee: CORNELL RESEARCH FOUNDATION, INC.
    Inventors: George P. Hess, Moataz M. Gadalla
  • Protecting group for carboxylic acids that can be photolyzed by visible light
    Patent number: 8053585
    Abstract: The present invention relates to a photolabile compound including a coumarin family caging group covalently bound to an organic moiety containing a carboxyl group, an amino group, a sulfhydryl group, and/or a hydroxyl group. The photolabile compound, upon absorbing visible light, releases the organic moiety. Also disclosed is a method of making a photolabile compound that releases a biologically active compound upon absorbing visible light by providing an organic moiety and binding a coumarin family caging group to the organic moiety under conditions effective to make the photolabile compound. The present invention also relates to a method of obtaining a biologically active compound in a sample. The method involves adding to a sample a photolabile compound including a coumarin family caging group covalently bound to an organic moiety. The sample is then illuminated with visible light under conditions effective to obtain a biologically active compound including the organic moiety.
    Type: Grant
    Filed: April 12, 2006
    Date of Patent: November 8, 2011
    Assignee: Cornell Research Foundation, Inc.
    Inventors: George P. Hess, Barry K. Carpenter, Vishakha R. Shembekar, Yongli Chen
  • INHIBITION OF BETA-AMYLOID PEPTIDE AGGREGATION
    Publication number: 20100069468
    Abstract: The present invention relates to methods of using cocaine-binding-site ligands and cocaine-binding-site RNA aptamers to treat or prevent Alzheimer's Disease and to reduce or prevent aggregation of beta-amyloid peptides in a subject.
    Type: Application
    Filed: July 12, 2007
    Publication date: March 18, 2010
    Applicant: CORNELL RESEARCH FOUNDATION, INC.
    Inventors: George P. Hess, Moataz M. Gadalla
  • Caged caboxyl compounds and use thereof
    Patent number: 5587509
    Abstract: A method of releasing a caged carboxylic acid in which a 2-alkoxy-5-nitro-phenyl photosensitive group blocks a carboxyl function and the compositions so produced are disclosed.
    Type: Grant
    Filed: March 8, 1995
    Date of Patent: December 24, 1996
    Assignee: Cornell Research Foundation, Inc.
    Inventors: George P. Hess, Barry K. Carpenter, Doraiswamy Ramesh, Raymond Wieboldt
  • Caged carboxyl compounds and use thereof
    Patent number: 5430175
    Abstract: Caged carboxyl compounds in which a 2-alkoxy-5-nitrophenyl photosensitive group blocks a carboxyl function are disclosed. Preferably the compounds are neuroactive amino acids. The compounds are photolyzable by laser pulses at wavelengths above about nm within about 3 .mu.s and provide a product quantum yield of greater than about 0.2.
    Type: Grant
    Filed: November 30, 1993
    Date of Patent: July 4, 1995
    Assignee: Cornell Research Foundation, Inc.
    Inventors: George P. Hess, Barry K. Carpenter, Doraiswamy Ramesh, Raymond Wieboldt