Patents by Inventor George Peter Lomonossoff

George Peter Lomonossoff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROTEIN EXPRESSION SYSTEMS
    Publication number: 20210155947
    Abstract: The invention is based on an expression enhancer sequence derived from the RNA-2 genome segment of a bipartite RNA virus, in which a target initiation site in the RNA-2 genome segment has been mutated. Deletion of appropriate start codons upstream of the main RNA2 translation initiation can greatly increase in foreign protein accumulation without the need for viral replication. Also provided are methods, vectors and systems, including the ‘hyper-translatable’ Cowpea Mosaic Virus (“CPMV-HT”) based protein expression system.
    Type: Application
    Filed: September 9, 2020
    Publication date: May 27, 2021
    Inventors: Frank Sainsbury, George Peter Lomonossoff
  • Protein expression systems
    Patent number: 10947549
    Abstract: The invention is based on an expression enhancer sequence derived from the RNA-2 genome segment of a bipartite RNA virus, in which a target initiation site in the RNA-2 genome segment has been mutated. Deletion of appropriate start codons upstream of the main RNA2 translation initiation can greatly increase in foreign protein accumulation without the need for viral replication. Also provided are methods, vectors and systems, including the ‘hyper-translatable’ Cowpea Mosaic Virus (“CPMV-HT”) based protein expression system.
    Type: Grant
    Filed: August 31, 2020
    Date of Patent: March 16, 2021
    Assignee: PLANT BIOSCIENCE LIMITED
    Inventors: Frank Sainsbury, George Peter Lomonossoff
  • PROTEIN EXPRESSION SYSTEMS
    Publication number: 20200392522
    Abstract: The invention is based on an expression enhancer sequence derived from the RNA-2 genome segment of a bipartite RNA virus, in which a target initiation site in the RNA-2 genome segment has been mutated. Deletion of appropriate start codons upstream of the main RNA2 translation initiation can greatly increase in foreign protein accumulation without the need for viral replication. Also provided are methods, vectors and systems, including the ‘hyper-translatable’ Cowpea Mosaic Virus (“CPMV-HT”) based protein expression system.
    Type: Application
    Filed: August 31, 2020
    Publication date: December 17, 2020
    Inventors: Frank Sainsbury, George Peter Lomonossoff
  • Protein expression systems
    Patent number: 10822613
    Abstract: The invention is based on an expression enhancer sequence derived from the RNA-2 genome segment of a bipartite RNA virus, in which a target initiation site in the RNA-2 genome segment has been mutated. Deletion of appropriate start codons upstream of the main RNA2 translation initiation can greatly increase in foreign protein accumulation without the need for viral replication. Also provided are methods, vectors and systems, including the ‘hyper-translatable’ Cowpea Mosaic Virus (“CPMV-HT”) based protein expression system.
    Type: Grant
    Filed: August 11, 2017
    Date of Patent: November 3, 2020
    Assignee: PLANT BIOSCIENCE LIMITED
    Inventors: Frank Sainsbury, George Peter Lomonossoff
  • PROTEIN EXPRESSION SYSTEMS
    Publication number: 20180030462
    Abstract: The invention is based on an expression enhancer sequence derived from the RNA-2 genome segment of a bipartite RNA virus, in which a target initiation site in the RNA-2 genome segment has been mutated. Deletion of appropriate start codons upstream of the main RNA2 translation initiation can greatly increase in foreign protein accumulation without the need for viral replication. Also provided are methods, vectors and systems, including the ‘hyper-translatable’ Cowpea Mosaic Virus (“CPMV-HT”) based protein expression system.
    Type: Application
    Filed: August 11, 2017
    Publication date: February 1, 2018
    Inventors: Frank Sainsbury, George Peter Lomonossoff
  • PROTEIN EXPRESSION SYSTEMS
    Publication number: 20140250549
    Abstract: The invention is based on an expression enhancer sequence derived from the RNA-2 genome segment of a bipartite RNA virus, in which a target initiation site in the RNA-2 genome segment has been mutated. Deletion of appropriate start codons upstream of the main RNA2 translation initiation can greatly increase in foreign protein accumulation without the need for viral replication. Also provided are methods, vectors and systems, including the ‘hyper-translatable’ Cowpea Mosaic Virus (“CPMV-HT”) based protein expression system.
    Type: Application
    Filed: February 4, 2014
    Publication date: September 4, 2014
    Applicant: PLANT BIOSCIENCE LIMITED
    Inventors: Frank Sainsbury, George Peter Lomonossoff
  • Protein expression system
    Patent number: 8674084
    Abstract: The inventions is based on an expression enhancer sequence derived from the RNA-2 genome segment of a bipartite RNA virus, in which a target initiation site in the RNA-2 genome segment has been mutated. Deletion of appropriate start codons upstream of the main RNA2 translation initiation can greatly increase in foreign protein accumulation without the need for viral replication. Also provided are methods, vectors and systems, including the ‘hyper-translatable’ Cowpea Mosaic Virus (‘CPMV-HT’) based protein expression system.
    Type: Grant
    Filed: January 8, 2009
    Date of Patent: March 18, 2014
    Assignee: Plant Bioscience Limited
    Inventors: Frank Sainsbury, George Peter Lomonossoff
  • PROTEIN EXPRESSION SYSTEMS
    Publication number: 20120284871
    Abstract: Disclosed herein are methods and materials, and particularly viral derived sequences, for boosting gene expression in plants and other eukaryotic cells. The methods and materials may be used for boosting expression of heterologous genes encoding proteins of interest.
    Type: Application
    Filed: May 4, 2012
    Publication date: November 8, 2012
    Applicant: PLANT BIOSCIENCE LIMITED
    Inventors: George Peter Lomonossoff, Pooja Saxena, Yulia Alexandrovna Meshcheriakova
  • PRODUCTION OF VIRAL CAPSIDS
    Publication number: 20120174263
    Abstract: The invention provides methods of producing “empty” RNA virus capsids (e.g. from Cowpea mosaic virus) by assembly of viral small (S) and large (L) coat proteins in such a way that encapsidation of native viral RNA is avoided. Aspects of the invention employ in planta expression of capsid components from DNA vectors encoding the S and L proteins or S-L polyproteins including them. Such capsids have utility for the encapsidation or presentation of foreign proteins or desired payloads.
    Type: Application
    Filed: June 15, 2010
    Publication date: July 5, 2012
    Applicant: PLANT BIOSCIENCE LIMITED
    Inventors: Keith Saunders, George Peter Lomonossoff, Frank Sainsbury
  • PROTEIN EXPRESSION SYSTEM
    Publication number: 20100287670
    Abstract: The inventions is based on an expression enhancer sequence derived from the RNA-2 genome segment of a bipartite RNA virus, in which a target initiation site in the RNA-2 genome segment has been mutated. Deletion of appropriate start codons upstream of the main RNA2 translation initiation can greatly increase in foreign protein accumulation without the need for viral replication. Also provided are methods, vectors and systems, including the ‘hyper-translatable’ Cowpea Mosaic Virus (‘CPMV-HT’) based protein expression system.
    Type: Application
    Filed: January 8, 2009
    Publication date: November 11, 2010
    Inventors: Frank Sainsbury, George Peter Lomonossoff
  • Modified plant viruses as vectors
    Patent number: 7208655
    Abstract: The invention relates to assembled particles of a plant virus containing a predetermined foreign peptide as part of the coat protein of the virus, and a method for their production. The foreign peptide is preferably a biologically functional peptide, the biological application of which requires or is enhanced by presentation of the peptide in association with a larger molecule or particle.
    Type: Grant
    Filed: May 30, 2000
    Date of Patent: April 24, 2007
    Assignee: The Dow Chemical Company
    Inventors: George Peter Lomonossoff, John Emil Johnson
  • Modified plant viruses as vectors
    Patent number: 6110466
    Abstract: The invention relates to assembled particles of a plant virus containing a predetermined foreign peptide as part of the coat protein of the virus, and a method for their production. The foreign peptide is preferably a biologically functional peptide, the biological application of which requires or is enhanced by presentation of the peptide in association with a larger molecule or particle.
    Type: Grant
    Filed: December 15, 1993
    Date of Patent: August 29, 2000
    Assignees: Axis Genetics PLC, Purdue Research Foundation
    Inventors: George Peter Lomonossoff, John Emil Johnson
  • Modified plant viruses as vectors of heterologous peptides
    Patent number: 5958422
    Abstract: The invention relates to assembled particles of a plant virus containing a foreign peptide insert in the coat protein of the virus. The site of the insert is free from direct sequence repeats flanking the insert. The invention also relates to a method of production of the particles and their use, in particular in vaccines.
    Type: Grant
    Filed: June 5, 1996
    Date of Patent: September 28, 1999
    Assignee: Axis Genetics PLC
    Inventor: George Peter Lomonossoff
  • Modified plant viruses as vectors
    Patent number: 5874087
    Abstract: The invention relates to assembled particles of a plant virus containing a predetermined foreign peptide as part of the coat protein of the virus, and a method for their production. The foreign peptide is preferably a biologically functional peptide, the biological application of which requires or is enhanced by presentation of the peptide in association with a larger molecule or particle.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: February 23, 1999
    Assignees: Axis Genetics PLC, Purdue Research Foundation
    Inventors: George Peter Lomonossoff, John Emil Johnson