Abstract: Provided are compounds of Formula (I?): or pharmaceutically acceptable salts thereof, wherein the variables in the formula are as defined herein; and methods for their use and production.

Abstract: A system for treating a subsurface hydrocarbon containing formation includes one or more shafts. A first substantially horizontal or inclined tunnel extends from one or more of the shafts. A second substantially horizontal or inclined tunnel extends from one or more of the shafts. Two or more heat source wellbores extend from the first tunnel to the second tunnel. The heat source wellbores are configured to allow heated fluid to flow through the wellbores from the first tunnel to the second tunnel.

Abstract: A system for treating a subsurface hydrocarbon containing formation includes one or more substantially horizontal or inclined tunnels extending from at least one shaft. One or more heater sources are located in one or more heater wellbores coupled to at least one of the substantially horizontal or inclined tunnels.

Abstract: A system for treating a subsurface hydrocarbon containing formation includes one or more substantially horizontal or inclined tunnels extending from one or more shafts. A production system is located in at least one of the tunnels. The production system is configured to produce fluids from the formation that collect in the tunnel.

Abstract: A method of heating a subsurface hydrocarbon containing formation includes providing heat flux per volume to a first portion of a subsurface hydrocarbon containing formation. The heat flux per volume is provided by two or more first heat sources positioned in the first portion. Heat flux per volume is provided to a second portion of the subsurface hydrocarbon containing formation with the heat flux per volume being provided by two or more second heat sources positioned in the second portion. The heat flux per volume provided by the two or more second heat sources is greater than the heat flux per volume provided by the two or more first heat sources. The second portion is positioned below the first portion.

Abstract: A system for treating a subsurface hydrocarbon containing formation includes one or more shafts. At least two substantially horizontal or inclined tunnels extend from one or more of the shafts. A plurality of heat sources are located in at least one heat source wellbore extending between at least two of the substantially horizontal tunnels. Electrical connections for the heat sources are located in at least one of the substantially horizontal tunnels.

Abstract: A system for treating a subsurface hydrocarbon containing formation includes one or more shafts. A first substantially horizontal or inclined tunnel extends from one or more of the shafts. A second substantially horizontal or inclined tunnel extends from one or more of the shafts. Two or more heat source wellbores extend from the first tunnel to the second tunnel. The heat source wellbores are configured to allow electrical current to flow between the heat source wellbores.

Abstract: A system for treating a subsurface hydrocarbon containing formation includes one or more tunnels having an average diameter of at least 1 m. At least one tunnel is connected to the surface. Two or more wellbores extend from at least one of the tunnels into at least a portion of the subsurface hydrocarbon containing formation. At least two of the wellbores contain elongated heat sources configured to heat at least a portion of the subsurface hydrocarbon containing formation such that at least some hydrocarbons are mobilized.

Abstract: A method of heating a subsurface hydrocarbon containing formation includes providing heat flux per volume to a first portion of a subsurface hydrocarbon containing formation. The heat flux per volume is provided by two or more first heat sources positioned in the first portion. Heat flux per volume is provided to a second portion of the subsurface hydrocarbon containing formation with the heat flux per volume being provided by two or more second heat sources positioned in the second portion. The heat flux per volume provided by the two or more second heat sources is greater than the heat flux per volume provided by the two or more first heat sources. The second portion is positioned below the first portion.

Abstract: An exemplary embodiment of the invention relates to a system and method for providing digital messaging services received from multiple sources over a communications network. The system includes a client system, including a display screen coupled to a communications link; a workstation including a web browser, a memory, and a processor, said workstation coupled to said communications link; a hosting system, including a graphics server, a content server, and a scheduling server, each in communication with each other via a communications link; and a workstation and data storage device coupled to the communications link; and a data storage device for storing data utilized by said hosting system. The client system requests and receives digital messaging services from said hosting system under a subscription agreement.

Abstract: A system for treating a subsurface hydrocarbon containing formation includes one or more substantially horizontal or inclined tunnels extending from at least one shaft. One or more heater sources are located in one or more heater wellbores coupled to at least one of the substantially horizontal or inclined tunnels.

Abstract: A system for treating a subsurface hydrocarbon containing formation includes one or more substantially horizontal or inclined tunnels extending from one or more shafts. A production system is located in at least one of the tunnels. The production system is configured to produce fluids from the formation that collect in the tunnel.

Abstract: A system for treating a subsurface hydrocarbon containing formation includes one or more shafts. At least two substantially horizontal or inclined tunnels extend from one or more of the shafts. A plurality of heat sources are located in at least one heat source wellbore extending between at least two of the substantially horizontal tunnels. Electrical connections for the heat sources are located in at least one of the substantially horizontal tunnels.

Abstract: A system for treating a subsurface hydrocarbon containing formation includes one or more shafts. A first substantially horizontal or inclined tunnel extends from one or more of the shafts. A second substantially horizontal or inclined tunnel extends from one or more of the shafts. Two or more heat source wellbores extend from the first tunnel to the second tunnel. The heat source wellbores are configured to allow electrical current to flow between the heat source wellbores.

Abstract: A system for treating a subsurface hydrocarbon containing formation includes one or more tunnels having an average diameter of at least 1 m. At least one tunnel is connected to the surface. Two or more wellbores extend from at least one of the tunnels into at least a portion of the subsurface hydrocarbon containing formation. At least two of the wellbores contain elongated heat sources configured to heat at least a portion of the subsurface hydrocarbon containing formation such that at least some hydrocarbons are mobilized.

Abstract: A system for treating a subsurface hydrocarbon containing formation includes one or more shafts. A first substantially horizontal or inclined tunnel extends from one or more of the shafts. A second substantially horizontal or inclined tunnel extends from one or more of the shafts. Two or more heat source wellbores extend from the first tunnel to the second tunnel. The heat source wellbores are configured to allow heated fluid to flow through the wellbores from the first tunnel to the second tunnel.

Abstract: A system for treating a subsurface hydrocarbon containing formation includes one or more substantially horizontal or inclined tunnels extending from at least one shaft. One or more heater sources are located in one or more heater wellbores coupled to at least one of the substantially horizontal or inclined tunnels.

Abstract: A system for treating a subsurface hydrocarbon containing formation includes one or more substantially horizontal or inclined tunnels extending from one or more shafts. A production system is located in at least one of the tunnels. The production system is configured to produce fluids from the formation that collect in the tunnel.

Abstract: An exemplary embodiment of the invention relates to a system and method for providing digital messaging services received from multiple sources over a communications network. The system includes a client system, including a display screen coupled to a communications link; a workstation including a web browser, a memory, and a processor, said workstation coupled to said communications link; a hosting system, including a graphics server, a content server, and a scheduling server, each in communication with each other via a communications link; and a workstation and data storage device coupled to the communications link; and a data storage device for storing data utilized by said hosting system.

Abstract: An exemplary embodiment of the invention relates to a system and method for providing digital messaging services received from multiple sources over a communications network. The system includes a client system, including a display screen coupled to a communications link; a workstation including a web browser, a memory, and a processor, said workstation coupled to said communications link; a hosting system, including a graphics server, a content server, and a scheduling server, each in communication with each other via a communications link; and a workstation and data storage device coupled to the communications link; and a data storage device for storing data utilized by said hosting system. The client system requests and receives digital messaging services from said hosting system under a subscription agreement.