Patents by Inventor George R. Kracke

George R. Kracke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NEUROMUSCULAR BLOCKING AGENTS
    Publication number: 20210047289
    Abstract: Disclosed herein are carborane derivatives of Formula I or Formula V, or a pharmaceutically acceptable salt thereof, for use as neuromuscular blocking agents. The carborane is substituted with two cationic functional groups selected from amines that form ammonium cations, ethers and/or alcohols that form oxonium cations, sulfides and/or thiols that form sulfonium cations, and phosphanes and/or phosphines that form phosphonium cations.
    Type: Application
    Filed: March 27, 2019
    Publication date: February 18, 2021
    Inventors: George R. Kracke, Lalit N. Goswami, Marion F Hawthorne, Satish S. Jalisatgi
  • BORON CLUSTER COMPOUNDS AND USES THEREOF
    Publication number: 20190135838
    Abstract: The present invention relates to novel boron cluster compounds and their use as sodium channel blockers. The invention also provides methods for making and using the compounds.
    Type: Application
    Filed: January 3, 2019
    Publication date: May 9, 2019
    Applicant: The Curators of the University of Missouri
    Inventors: George R. Kracke, Yulia Sevryugina, Marion Frederick Hawthorne
  • Boron cluster compounds and uses thereof
    Patent number: 10202406
    Abstract: The present invention relates to novel cluster boron compounds and their use as sodium channel blockers. The invention also provides methods for making and using the compounds.
    Type: Grant
    Filed: August 18, 2015
    Date of Patent: February 12, 2019
    Assignee: THE CURATORS OF THE UNIVERSITY OF MISSOURI
    Inventors: George R. Kracke, Yulia Sevryugina, Marion Frederick Hawthorne
  • CLUSTER BORON COMPOUNDS AND USES THEREOF
    Publication number: 20160031912
    Abstract: The present invention relates to novel cluster boron compounds and their use as sodium channel blockers. The invention also provides methods for making and using the compounds.
    Type: Application
    Filed: August 18, 2015
    Publication date: February 4, 2016
    Applicant: THE CURATORS OF THE UNIVERSITY OF MISSOURI
    Inventors: George R. Kracke, Yulia Sevryugina, Marion Frederick Hawthorne
  • Cluster boron compounds and uses thereof
    Patent number: 9217002
    Abstract: The present invention relates to novel cluster boron compounds and their use as sodium channel blockers. In particular, the novel cluster boron compounds may be lidocaine analogs where the aromatic ring of the lidocaine molecule is replaced with a cluster boron group. The invention also provides methods for making the cluster boron compounds comprising contacting a halogenated cluster boron with an amino acetamide in the presence of a catalyst, a proton acceptor, and a ligand.
    Type: Grant
    Filed: September 13, 2012
    Date of Patent: December 22, 2015
    Assignee: The Curators of the University of Missouri
    Inventors: George R. Kracke, Yulia Sevryugina, Marion Frederick Hawthorne
  • CLUSTER BORON COMPOUNDS AND USES THEREOF
    Publication number: 20150072956
    Abstract: The present invention relates to novel cluster boron compounds and their use as sodium channel blockers. In particular, the novel cluster boron compounds may be lidocaine analogs where the aromatic ring of the lidocaine molecule is replaced with a cluster boron group. The invention also provides methods for making the cluster boron compounds comprising contacting a halogenated cluster boron with an amino acetamide in the presence of a catalyst, a proton acceptor, and a ligand.
    Type: Application
    Filed: September 13, 2012
    Publication date: March 12, 2015
    Applicant: The Curators of the University of Missouri
    Inventors: George R. Kracke, Yulia Sevryugina, Marion Frederick Hawthorne