Patents by Inventor George R. Lenz

George R. Lenz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CD40:CD154 binding interrupter compounds and use thereof to treat immunological complications
    Patent number: 7173046
    Abstract: The present invention relates to novel CD40:CD154 binding interrupter compounds and use of these compounds and pharmaceutical compositions comprising them, to treat conditions associated with inappropriate CD154 activation in a subject. Specifically, this invention provides compounds which are identified by screening a library of small molecules for those that are capable of specifically binding CD154 and interrupting CD40:CD154 interaction.
    Type: Grant
    Filed: February 28, 2003
    Date of Patent: February 6, 2007
    Assignee: Biogen, Inc.
    Inventors: Zhongli Zheng, Mary-Beth Carter, YuSheng Liao, Lihong Sun, Leonid Kirkovsky, Susan Mrose, Yen-Ming Hsu, David Thomas, Gerald W. Shipps, Jr., Satish Jindal, George R. Lenz, Huw M. Nash
  • Novel CD40 : CD154 binding interruptor compounds and use thereof to treat immunological complications
    Publication number: 20040067982
    Abstract: The present invention relates to novel CD40:CD154 binding interrupter compounds and use of these compounds and pharmaceutical compositions comprising them, to treat conditions associated with inappropriate CD154 activation in a subject. Specifically, this invention provides compounds which are identified by screening a library of small molecules for those that are capable of specifically binding CD154 and interrupting CD40:CD154 interaction.
    Type: Application
    Filed: February 28, 2003
    Publication date: April 8, 2004
    Inventors: Zhongli Zheng, Mary-Beth Carter, YuSheng Liao, Lihong Sun, Leonid Kirkovsky, Susan Mrose, Yen-Ming Hsu, David Thomas, Gerald W. Shipps, Satish Jindal, George R. Lenz, Huw M. Nash
  • Methods for forming combinatorial libraries combining amide bond formation with epoxide opening
    Publication number: 20020077491
    Abstract: The invention relates to methods for forming combinatorial libraries. The invention provides methods suitable for the rapid and convenient synthesis of very large combinatorial libraries of small organic molecules. In particular, the invention provides a method for forming combinatorial libraries combining amide bond formation with epoxide opening.
    Type: Application
    Filed: August 31, 2001
    Publication date: June 20, 2002
    Inventors: Gerald W. Shipps, Kristin E. Rosner, Gergely M. Makara, Edward A. Wintner, Huw M. Nash, Jason S. Felsch, Kollol Pal, George R. Lenz
  • Benzothiazine derivatives
    Patent number: 4500708
    Abstract: The present invention relates to a class of novel annulated 4H-1,4-benzothiazine derivatives. The invention further relates to pharmaceutical compositions containing such annulated benzothiazine derivatives and to the use of such compounds and compositions as anorectic agents. In particular, certain of the novel annulated 4H-1,4-benzothiazine derivatives are effective anorectic agents when administered orally.
    Type: Grant
    Filed: April 23, 1984
    Date of Patent: February 19, 1985
    Assignee: G. D. Serle & Co.
    Inventors: Robert J. Chorvat, George R. Lenz, Suzanne Evans Radak
  • 3-Oxoestra-17-acetonitrile and unsaturated analogs
    Patent number: 4389345
    Abstract: This invention relates to cyano steroids of formula I. These compounds exhibit progestational activity.
    Type: Grant
    Filed: October 9, 1981
    Date of Patent: June 21, 1983
    Assignee: G.D. Searle & Co.
    Inventor: George R. Lenz
  • 21-(Acetyloxy)-3-oxo-24-norchola-4,20(22)-diene-23-nitrile and intermediates thereto
    Patent number: 4110325
    Abstract: Preparation of 21-(acetyloxy)-3-oxo-24-norchola-4,20(22)-diene-23-nitrile; its diuretic, antiulcerogenic, and antiviral utility; and intermediates whereby the preparation can be variously effected are disclosed.
    Type: Grant
    Filed: August 10, 1977
    Date of Patent: August 29, 1978
    Assignee: G. D. Searle & Co.
    Inventors: George R. Lenz, John A. Schulz
  • (8.alpha.,13A.beta.)-8-CARBOCYCLIC/CARBOCYCLIC METHYL-5,8,13,13A-TETRAHYDRO-2,3,10,11-TETRAMETHOXY-6H-dibenzo[a,g]quino lizines and intermediates thereto
    Patent number: 4013666
    Abstract: Preparation of antiarrhythmic and antifungal (8.alpha.,13a.beta. )-8-carbocyclic/carbocyclic methyl-5,8,13,13a-tetrahydro-2,3,10,11-tetramethoxy-6H-dibenzo[a,g]quinoli zines is disclosed.
    Type: Grant
    Filed: March 15, 1976
    Date of Patent: March 22, 1977
    Assignee: G. D. Searle & Co.
    Inventor: George R. Lenz
  • [8 .alpha.(E), 13a.beta.]-5,8,13,13a-tetrahydro-2,3,10,11-tetramethoxy-8-(2-phenylethen yl)-6H-dibenzo[a,g]quinolizines and intermediates thereto
    Patent number: 4013644
    Abstract: Preparation of antifungal [8.alpha.(E),13a.beta.]-5,8,13,13a-tetrahydro-2,3,10,11-tetramethoxy-8-(2- phenylethenyl)-6H-dibenzo[a,g]quinolizines is disclosed.
    Type: Grant
    Filed: March 15, 1976
    Date of Patent: March 22, 1977
    Assignee: G. D. Searle & Co.
    Inventor: George R. Lenz