Patents by Inventor George R. Newkome
George R. Newkome has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20100041859Abstract: In accordance with the present invention, there is provided a method of preparing higher generation 1?3 C-branched polyamide dendrons. The combination of commercially available acryloyl chloride with 1?3 C-branched amines, e.g., di-tert-butyl 4-[2-(tert-butoxycarbonyl)ethyl]-4-aminoheptanedioate, resulted in generally high yields of acryl amides, which upon treatment with other reagents, generated the desired higher generation dendrons. These second and third generation dendrons were fully characterized and compared to the samples prepared from a convergent synthesis.Type: ApplicationFiled: November 11, 2005Publication date: February 18, 2010Applicant: THE UNIVERSITY OF AKRONInventors: George R. Newkome, Charles N. Moorefield, Kishore K. Kotta
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Publication number: 20100013382Abstract: The invention is directed to a method of preparing polymeric metallomacrocycles having measurable photo- and electroluminescence properties and devices using such materials. In an embodiment an O-hexyl-3,5-bis(terpyridine)phenol ligand has been synthesized and transformed into a hexagonal Zn(II)-metallomacrocycle by a facile self-assembly procedure capitalizing on terpyridine-Zn(II)-terpyridine connectivity. The material is usable in an OLED device based on the photo- and electro-luminescence characteristics thereof.Type: ApplicationFiled: August 24, 2007Publication date: January 21, 2010Applicant: THE UNIVERSITY OF AKRONInventors: George R. Newkome, Charles N. Moorefield
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Publication number: 20100001235Abstract: The invention is directed to quantum dot nanoparticles and methods of preparation. Using regioselective dendritic functionalized cellulose, quantum dots may be embedded in the modified cellulosic material. The quantum dot nanoparticles provide use for biotechnology or biomedicinal applications. Photooptical properties and morphology for use in as well as its biocompatibility were investigated.Type: ApplicationFiled: May 23, 2007Publication date: January 7, 2010Applicant: THE UNIVERSITY OF AKRONInventors: George R. Newkome, Charles N. Moorefield
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Patent number: 7589229Abstract: A method for forming cascade polymers specifically utilizing the amine monomer of the formula The monomer is made by initially reacting nitromethane and CH2?CHCO2— TBu by nucleophilic addition to form the triester nitrotrialkanoate of the formula and then reducing the nitrosubstituent to afford the said amine monomer.Type: GrantFiled: January 26, 2007Date of Patent: September 15, 2009Assignee: The University of South FloridaInventors: George R. Newkome, Charles N. Moorefield, Rajani K. Behera
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Publication number: 20090171088Abstract: In accordance with the present invention, there is provided a method for preparing a reversible, self-assembly of an imbedded hexameric metallomacrocycle within a macromolecular superstructure. The method occurs by an intramolecular mechanism in which a macromolecular skeleton possesses multiple ligands capable of reversible assembly-disassembly triggered by the presence of metal ions.Type: ApplicationFiled: November 23, 2005Publication date: July 2, 2009Applicant: THE UNIVERSITY OF AKRONInventors: George R. Newkome, Charles N. Moorefield, Pingshan Wang
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Publication number: 20090131656Abstract: The invention relates to the formation of synthesized fractal constructs and the methods of chemical self-assembly for the preparation of a non-dendritic, nano-scale, fractal constructs or molecules. More particularly, the invention relates to fractal constructs formed by molecular self-assembly, to create synthetic, nanometer-scale fractal shapes. In an embodiment, a nanoscale Sierpinski hexagonal gasket is formed. This non-dendritic, perfectly self-similar fractal macromolecule is comprised of bisterpyridine building blocks that are bound together by coordination to 36 Ru and 6 Fe ions to form a nearly planar array of increasingly larger hexagons around a hollow center.Type: ApplicationFiled: May 10, 2007Publication date: May 21, 2009Inventors: George R. Newkome, Charles N. Moorefield
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Patent number: 7250534Abstract: A compound consists of a fractal-like, plain or organometallic array useful for energy storage devices. A dendrimer useful in the synthesis of the fractal-like compound includes a single ligating moiety bound to a surface of each quadrant of the dendrimer. A method of making metallo-based (macro) molecules includes the steps of combining monomers selected from the group consisting of bipyridal- and terpyridal-based ligands with connecting metals and self assembling macrocycles wherein the monomes are interconnected by the metals.Type: GrantFiled: July 20, 2000Date of Patent: July 31, 2007Assignee: University of South FloridaInventor: George R. Newkome
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Patent number: 7183426Abstract: A method for forming cascade polymers specifically utilizing the amine monomer of the formula The monomer is made by initially reacting nitromethane and CH2?CHCO2-TBu by nucleophilic addition to form the triester nitrotrialkanoate of the formula and then reducing the nitrosubstituent to afford the said amine monomer.Type: GrantFiled: June 16, 2003Date of Patent: February 27, 2007Inventors: George R. Newkome, Charles N. Moorefield, Rajani K. Behera
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Publication number: 20030097019Abstract: A method for forming cascade polymers specifically utilizing the amine monomer of the formula 1Type: ApplicationFiled: August 29, 1996Publication date: May 22, 2003Inventors: GEORGE R. NEWKOME, CHARLES N. MOOREFIELD
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Patent number: 6566409Abstract: A lock unimolecular micelle includes at least one engineered acceptor specifically binding a ligand (or specifically a “key” unimolecular micelle) thereto. A key unimolecular micelle comprises a core molecule and a plurality of branches extending therefrom, at least one of the branches including a shank portion extending therefrom having a terminal moiety at an end thereof for binding to a complimentary acceptor of a lock unimolecular micelle. Together, the lock and key micelles form a unit, either irreversibly or reversibly bound wherein the lock micelles is a soluble receptor engineered to specifically bind to the specifically engineered key micelle.Type: GrantFiled: May 8, 2000Date of Patent: May 20, 2003Assignee: University of South FloridaInventors: George R. Newkome, Charles N. Moorefield, Gregory Baker
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Patent number: 6399717Abstract: There is provided dendritic materials for enhanced performance of an energy storage device having a unimolecular micelle including branched building blocks. Also provided is an energy storage device having a lithium source, a hydrocarbon dendrimer based electrolyte made up of a unimolecular micelle including branched building blocks, insertional electrode, and a current conductor.Type: GrantFiled: November 22, 2000Date of Patent: June 4, 2002Assignee: The University of South FloridaInventors: George R. Newkome, Charles N. Moorefield
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Patent number: 6130209Abstract: A lock unimolecular micelle includes at least one engineered acceptor specifically binding a ligand (or specifically a "key" unimolecular micelle) thereto. A key unimolecular micelle comprises a core molecule and a plurality of branches extending therefrom, at least one of the branches including a shank portion extending therefrom having a terminal moiety at an end thereof for binding to a complimentary acceptor of a lock unimolecular micelle. Together, the lock and key micelles form a unit, either irreversibly or reversibly bound wherein the lock micelles is a soluble receptor engineered to specifically bind to the specifically engineered key micelle.Type: GrantFiled: April 24, 1998Date of Patent: October 10, 2000Assignee: University of South FloridaInventors: George R. Newkome, Charles N. Moorefield, Gregory Baker
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Patent number: 5886126Abstract: The method of forming a surface layer on a substrate is accomplished by dendrimerizing a mixture of branched monomers on the substrate surface wherein the monomers have heterogeneous functionalized branches and homogenous connectivity to the substrate. A cascade polymer coated substrate is formed consisting essentially of a substrate including a surface and at least one dendrimerized surface layer consisting of heterogeneous functionalities the layer being linked to the substrate by homogenous linkages, preferably isocyanate linkages.Type: GrantFiled: August 28, 1996Date of Patent: March 23, 1999Assignee: University of South FloridaInventors: George R. Newkome, Charles N. Moorefield
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Patent number: 5886127Abstract: The method of forming a surface layer on a substrate is accomplished by dendrimerizing a mixture of branched monomers on the substrate surface wherein the monomers introduce heterogeneous functionalized branches and homogenous connectivity to the substrate. A cascade polymer coated substrate is formed consisting essentially of a substrate including a surface and at least one dendrimerized surface layer consisting of heterogeneous functionalities the layer being linked to the substrate by homogenous linkages, preferably isocyanate linkages.Type: GrantFiled: November 19, 1997Date of Patent: March 23, 1999Assignee: University of South FloridaInventors: George R. Newkome, Charles N. Moorefield
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Patent number: 5863919Abstract: A lock unimolecular micelle includes at least one engineered acceptor specifically binding a ligand (or specifically a "key" unimolecular micelle) thereto. A key unimolecular micelle comprises a core molecule and a plurality of branches extending therefrom, at least one of the branches including a shank portion extending therefrom having a terminal moiety at an end thereof for binding to a complimentary acceptor of a lock unimolecular micelle. Together, the lock and key micelles form a unit, either irreversibly or reversibly bound wherein the lock micelles is a soluble receptor engineered to specifically bind to the specifically engineered key micelle.Type: GrantFiled: August 28, 1996Date of Patent: January 26, 1999Assignee: University of South FloridaInventors: George R. Newkome, Charles N. Moorefield, Gregory Baker
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Patent number: 5773551Abstract: A method of synthesizing multi-tier cascade polymers and the polymers made thereby are formed by reacting at least one tier of a polymer with a functionalized isocyanate having the following formula:O.dbd.C.dbd.N--C(CH.sub.2 --R).sub.3with R being selected from the group including:a) --(CH.sub.2).sub.n --CH.sub.2 --COOR'with R' being selected from the group consisting of alkyl, cycloalkyl, aryl, heteroaryl-polycycloalkyl, adamantyl, n.dbd.0-10;b) --O--(CH.sub.2).sub.n --CH.sub.2 COOR'c) --O--(CH.sub.2).sub.n --CH.sub.2 --CNwith R' being selected from the group consisting of alkyl (C-1 to C-20), cycloalkyl (C-3 to C-10), aryl, heteroaryl, polycycloalkyl, adamantyl, n=0-10; andd) --CH.sub.2 --(CH.sub.2).sub.n --O--R"with n=0-10, R" being selected from the group consisting of alkyl, cycloalkyl, aryl, heteroaryl ester functionality, and a sulphur or a silicon atom bearing substituents selected from the group including: ##STR1## --SO.sub.2 --R'", --SiR'".sub.3 --(CH.sub.2 ).sub.n --CH.sub.2 --CN, --(CH.sub.2 ).Type: GrantFiled: August 28, 1996Date of Patent: June 30, 1998Assignee: University of South FloridaInventors: George R. Newkome, Claus Weis
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Patent number: 5703271Abstract: A method of synthesizing multitier cascade polymers and the polymers made thereby are formed by reacting at least one tier of a polymer with a functionalized isocyanate having the following formula:O.dbd.C.dbd.N--C(CH.sub.2 --R).sub.3with R being selected from the group including:--(CH.sub.2).sub.n --CH.sub.2 --COOR' a)with R' being selected from the group consisting of alkyl, cycloalkyl, aryl, heteroaryl- polycycloalkyl, adamantyl, n=0-10;--O--(CH.sub.2).sub.n --CH.sub.2 --COOR'--O--(CH.sub.2).sub.n --CH.sub.2 --CN b)with R' being selected from the group consisting of alkyl (c-1 to C(20), cycloalkyl (C-3 to C-10), aryl heteroaryl, polycycloalkyl, adamantyl, n=0-10; and--CH.sub.2 --(CH.sub.2).sub.Type: GrantFiled: April 2, 1996Date of Patent: December 30, 1997Assignee: University of South FloridaInventors: George R. Newkome, Claus Weis
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Patent number: 5650101Abstract: A lock unimolecular micelle includes at least one engineered acceptor specifically binding a ligand (or specifically a "key" unimolecular micelle) thereto. A key unimolecular micelle comprises a core molecule and a plurality of branches extending therefrom, at least one of the branches including a shank portion extending therefrom having a terminal moiety at an end thereof for binding to a complimentary acceptor of a lock unimolecular micelle. Together, the lock and key micelles form a unit, either irreversibly or reversibly bound wherein the lock micelles is a soluble receptor engineered to specifically bind to the specifically engineered key micelle.Type: GrantFiled: July 25, 1994Date of Patent: July 22, 1997Assignee: University of South FloridaInventors: George R. Newkome, Charles N. Moorefield, Gregory R. Baker
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Patent number: 5585457Abstract: Unimolecular micelies, generally referred to as cascade polymers, are constructed via the addition of successive layers, or tiers, of designed monomers, or building blocks, that possess a predetermined, branched superstructure consisting of connected physical matter inherently defining an internal void volume or void area within the molecular framework. Each of the branches define a flexible arm from a central core atom and terminate with a hydrodynamic reactive group. A method is described for manipulating such cascade polymers.Type: GrantFiled: June 5, 1995Date of Patent: December 17, 1996Assignee: University of South FloridaInventors: George R. Newkome, Charles N. Moorefield
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Patent number: 5516810Abstract: Unimolecular micelles, generally referred to as cascade polymers, are constructed via the addition of successive layers, or tiers, of designed monomers, or building blocks, that possess a predetermined, branched superstructure consisting of connected physical matter inherently defining an internal void volume or void area within the molecular framework. Reactive sites located on the framework and hence within the void regions are capable of being chemically transformed to allow covalent and noncovalent incorporation of one or more guest species into the said void regions. Further, a method is described for making such cascade polymers that includes the steps of forming a unimolecular micelle containing internal void areas with accessible reactive sites capable of bonding to at least one guest after construction of the said unimolecular micelle. The guests are contained within the internal void volume of the cascade polymer and are available and accessible for additional chemical modification.Type: GrantFiled: February 14, 1994Date of Patent: May 14, 1996Assignee: University of South FloridaInventors: George R. Newkome, Charles N. Moorefield