Patents by Inventor George R. Pettit

George R. Pettit has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis of dolastatin 10
    Patent number: 4978744
    Abstract: A complicated but extremely important scheme of synthesis has been developed for synthesizing, dolaisoleuine, dolaproine, dolaphenine and dolavaline from readily available starting materials such as Z-(S,S)isoleucine, S-phenylalaline, S-phenylalaninol, S-prolinol, S-mandelate, and S-valine. The requisite amino acids have been combined using several peptide coupling procedures to create pharmaceutically pure dolastatin 10.
    Type: Grant
    Filed: January 27, 1989
    Date of Patent: December 18, 1990
    Assignee: Arizona Board of Regents
    Inventors: George R. Pettit, Sheo B. Singh
  • Cell growth inhibitory macrocyclic lactones denominated Combretastatin D-1 and Combretastatin D-2
    Patent number: 4940726
    Abstract: The isolation and elucidation of novel caffrane macrocyclic lactones denominated "Combretastatin D-1" and "Combretastatin D-2", each of which was found to possess unexpected cell growth inhibitory properties.
    Type: Grant
    Filed: April 26, 1989
    Date of Patent: July 10, 1990
    Assignee: Arizona Board of Regents
    Inventors: George R. Pettit, Sheo B. Singh
  • Isolation and structural elucidation of the cytostatic linear depsipeptide dolastatin 15
    Patent number: 4879278
    Abstract: A new cytostatic depsipeptide, designated "dolastatin 15", was isolated from the Indian Ocean shell-like mollusk Dolabella auricularia. Dolastatin 15 inhibited growth of the PS leukemia with ED.sub.50 0.0024 .mu.g/mL. Pharmaceutical preparations and therapeutic regimens utilizing Dolastatin 15, its synthetic counterpart and pharmaceutically active derivatives are disclosed.
    Type: Grant
    Filed: May 16, 1989
    Date of Patent: November 7, 1989
    Assignee: Arizona Board of Regents
    Inventors: George R. Pettit, Yoshiaki Kamano
  • Isolation and structural elucidation of cephalostatins 1-4
    Patent number: 4873245
    Abstract: The marine worm Cephalodiscus gilchristi (Hemichordata phylum) from Southeast Africa has been found to contain powerful inhibitors of the murine P388 lymphocytic leukemia, herein denominated "cephalostatin 1, cephalostatin 2, cephalostatin 3 and cephalostatin 4". Pharmaceutical preparations containing the substances and methods of use are described.
    Type: Grant
    Filed: March 14, 1988
    Date of Patent: October 10, 1989
    Assignee: Arizona Board of Regents
    Inventors: George R. Pettit, Yoshiaki Kamano
  • Method of inhibiting leukemias and sarcomas in a mammalian host
    Patent number: 4866071
    Abstract: A new antineoplastic substance denominated "pancratistatin". Methods of isolating natural and synthetic pancratistatin and 7-deoxynarciclasine and the pharmaceutically acceptable derivatives thereof to make a pharmaceutical preparation therefrom and methods for treating a host afflicted with a neoplasm with said preparations.
    Type: Grant
    Filed: January 6, 1987
    Date of Patent: September 12, 1989
    Assignee: Arizona Board of Regents
    Inventor: George R. Pettit
  • Compositions of matter and methods of using same
    Patent number: 4833257
    Abstract: New and exceptionally potent antineoplastic agents denominated Bryostatin 9, Bryostatin 10, Bryostatin 11, Bryostatin 12 and Bryostatin 13 have been isolated from the marine animal Bugula neritina (Linneaeus) (Bryozoan phylum) and the structures identified. Meaningful antineoplastic activity is found for each.
    Type: Grant
    Filed: July 28, 1986
    Date of Patent: May 23, 1989
    Assignee: Arizona Board of Regents
    Inventors: George R. Pettit, Cherry L. Herald, Yoshiaki Kamano, John E. Leet
  • Cell growth inhibitory substance
    Patent number: 4816444
    Abstract: A potent cell growth inhibitory substance obtained from the Indian Ocean sea hare Dolabella, herein denominated "dolastatin 10"; and pharmaceutical preparations containing same; and methods useful for the treatment of a host afflicted with neoplastic disease therewith.
    Type: Grant
    Filed: July 10, 1987
    Date of Patent: March 28, 1989
    Assignee: Arizona Board of Regents, Arizona State University
    Inventors: George R. Pettit, Cherry L. Herald, Yoshiaki Kamano
  • Bryostatins 4 to 8
    Patent number: 4611066
    Abstract: New and potent antineoplastic agents designated bryostatin 4, bryostatin 5, bryostatin 6, bryostatin 7, and bryostatin 8 have been isolated from the marine animal Bugula neritina L. and Amatnea convoluta (Bryozoan phylum).
    Type: Grant
    Filed: August 10, 1984
    Date of Patent: September 9, 1986
    Assignee: Arizona State University
    Inventors: George R. Pettit, Cherry L. Herald, Yoskiaki Kamano
  • Macrocyclic lactones
    Patent number: 4560774
    Abstract: New and exceptionally potent antineoplastic agents designated bryostatin 1, bryostatin 2 and bryostatin 3 have been isolated from the marine animal Bugula neritina L. (Bryozoan phylum). An x-ray crystallographic analysis led to the assignment of novel structures shown in Charts I, II and III.
    Type: Grant
    Filed: July 12, 1983
    Date of Patent: December 24, 1985
    Assignee: Arizona State University
    Inventors: George R. Pettit, Cherry L. Herald
  • Dolastatins A and B cell growth inhibitory substances
    Patent number: 4486414
    Abstract: Potent cell growth inhibitory substances have been obtained from the Indian Ocean sea hare Dolabella. These substances have been given the names dolastatin A and dolastatin B. These compounds are characterized by physical and chemical parameters.
    Type: Grant
    Filed: March 21, 1983
    Date of Patent: December 4, 1984
    Assignee: Arizona Board of Reagents
    Inventor: George R. Pettit
  • Cell growth inhibitory substances
    Patent number: 4414205
    Abstract: Potent cell growth inhibitory substances have been obtained from the Indian Ocean sea hare Dolabella. These substances have been given the names dolastatin 1, dolastatin 2, and dolastatin 3. These compounds are characterized by physical and chemical parameters. Their utility as antiviral agents is supported by the disclosure of various preparations for such use.
    Type: Grant
    Filed: August 28, 1981
    Date of Patent: November 8, 1983
    Assignee: University Patents, Inc.
    Inventor: George R. Pettit
  • Phyllanthostatin compounds
    Patent number: 4388457
    Abstract: New antineoplastic glycosides, phyllanthostatin 1, 2 and 3, and the related glycoside, phyllanthoside, have been isolated from the Central American tree, Phyllanthus acuminatus Vahl. These compounds exhibit activity against the National Cancer Institute's P388 lymphocytic leukemia. Also, phyllanthoside was found to possess a curative level of activity against the murine B16 malanoma.
    Type: Grant
    Filed: February 11, 1982
    Date of Patent: June 14, 1983
    Assignee: University Patents, Inc.
    Inventor: George R. Pettit
  • 1,4-Bis(2-haloethyl)-1,4-diazabicyclo[2.2.1]-heptane dihydrogen dimaleate and selected salts
    Patent number: 4306071
    Abstract: 1,4-Bis(2'-haloethyl)-1,4-diazabicyclo[2.2.1]-heptane derivatives, such as diperchlorate, dichloride, diacetate, dibenzoate, diascorbate, disalicylate, ditartrate, disaccharin, dihydrogen dimaleate, together with ethyl sulfonate and periodate.
    Type: Grant
    Filed: November 14, 1979
    Date of Patent: December 15, 1981
    Assignee: The United States of America as represented by the Department of Health & Human Services
    Inventors: George R. Pettit, Donald P. Gieschen, William E. Pettit