Patents by Inventor George R. Simon

George R. Simon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Oncotherapeutic application of inhibitors of high-affinity glucose transporters
    Patent number: 8999326
    Abstract: The subject invention concerns materials and methods for treating oncological disorders in a person or animal using any agent or compound that inhibits uptake of glucose into a cell. The subject invention also concerns methods for inducing apoptosis and inhibiting the proliferation or survival of a cell. In one embodiment, the methods comprise administering an effective amount of an agent or compound that inhibits the activity of one or more glucose transporter proteins, such as Glut-1. An antibody that binds to and inhibits a glucose transporter protein can be used in the present methods.
    Type: Grant
    Filed: August 15, 2008
    Date of Patent: April 7, 2015
    Assignee: University of South Florida
    Inventor: George R. Simon
  • Predictive value of nuclear excision repair genes for cancer survival
    Patent number: 8580498
    Abstract: Patients who have their cancer surgically removed are at risk for recurrence, even though currently free of disease. Lung cancer patients with higher activity of a nuclear excision repair gene called ERCC1 were at a lower risk for recurrence than patients with lower activity of ERCC1. Hence, it is possible to predict which patients are at a higher risk for recurrence after resection. This information can be used to design treatment strategies for patients determined to be at a higher risk for recurrence. Additionally, patients who are lower risk for recurrence can be saved the morbidity of further treatment.
    Type: Grant
    Filed: February 14, 2011
    Date of Patent: November 12, 2013
    Assignee: University of South Florida
    Inventors: George R. Simon, Gerold Bepler
  • PREDICTIVE VALUE OF NUCLEAR EXCISION REPAIR GENES FOR CANCER SURVIVAL
    Publication number: 20110143361
    Abstract: Patients who have their cancer surgically removed are at risk for recurrence, even though currently free of disease. Lung cancer patients with higher activity of a nuclear excision repair gene called ERCC1 were at a lower risk for recurrence than patients with lower activity of ERCC1. Hence, it is possible to predict which patients are at a higher risk for recurrence after resection. This information can be used to design treatment strategies for patients determined to be at a higher risk for recurrence. Additionally, patients who are lower risk for recurrence can be saved the morbidity of further treatment.
    Type: Application
    Filed: February 14, 2011
    Publication date: June 16, 2011
    Applicant: University of South Florida
    Inventors: George R. Simon, Gerold Bepler
  • Oncotherapeutic Application of Inhibitors of High-Affinity Glucose Transporters
    Publication number: 20110104249
    Abstract: The subject invention concerns materials and methods for treating oncological disorders in a person or animal using any agent or compound that inhibits uptake of glucose into a cell. The subject invention also concerns methods for inducing apoptosis and inhibiting the proliferation or survival of a cell. In one embodiment, the methods comprise administering an effective amount of an agent or compound that inhibits the activity of one or more glucose transporter proteins, such as Glut-1. An antibody that binds to and inhibits a glucose transporter protein can be used in the present methods.
    Type: Application
    Filed: August 15, 2008
    Publication date: May 5, 2011
    Applicant: University of South Florida
    Inventor: George R. Simon