Patents by Inventor George Richard Uhl

George Richard Uhl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PTPRD inhibitors and uses thereof
    Patent number: 11987564
    Abstract: Disclosed are small molecule PTPRD inhibitors and uses thereof. Methods of using the PTPRD inhibitors include methods of treating, preventing, or delaying the progression of a disorder responsive to PTPRD inhibition, including for example nicotine dependence, addiction, obesity, metabolic syndrome, and substance-use disorders such as stimulant-use disorders and opioid-use disorders.
    Type: Grant
    Filed: May 2, 2022
    Date of Patent: May 21, 2024
    Assignees: Arizona Board of Regents on Behalf of the University of Arizona, The United States Government as respresented by the Department of Veterans Affairs, The University of Kentucky Research Foundation
    Inventors: George Richard Uhl, Ian M. Henderson, Wei Wang, Thomas Prisinzano
  • Compounds for Treating Tauopathies and Restless Leg Syndrome and Methods of Using and Screening for Same
    Publication number: 20230190701
    Abstract: Provided are compounds capable of enhancing the ability of receptor-type tyrosine-protein phosphatase delta (PTPRD) to dephosphorylate a kinase. Also disclosed is a method of treating a tauopathy or restless leg syndrome in a subject comprising administering to the subject an effective amount of a disclosed compound. Also disclosed are kits comprising the compounds together with instructions for treating a condition and/or a compound known for treating the condition. Finally, disclosed herein is a screening method suitable for identifying positive allosteric modulators of the ability of a receptor-type tyrosine-protein phosphatase delta (PTPRD) to dephosphorylate a kinase.
    Type: Application
    Filed: March 2, 2023
    Publication date: June 22, 2023
    Inventors: George Richard Uhl, Ian M. Henderson
  • PTPRD INHIBITORS AND USES THEREOF
    Publication number: 20220380332
    Abstract: Disclosed are small molecule PTPRD inhibitors and uses thereof. Methods of using the PTPRD inhibitors include methods of treating, preventing, or delaying the progression of a disorder responsive to PTPRD inhibition, including for example nicotine dependence, addiction, obesity, metabolic syndrome, and substance-use disorders such as stimulant-use disorders and opioid-use disorders.
    Type: Application
    Filed: May 2, 2022
    Publication date: December 1, 2022
    Inventors: George Richard Uhl, Ian M. Henderson, Wei Wang, Thomas Prisinzano
  • Compounds for Treating Tauopathies and Restless Leg Syndrome and Methods of Using and Screening for Same
    Publication number: 20220031653
    Abstract: Provided are compounds capable of enhancing the ability of receptor-type tyrosine-protein phosphatase delta (PTPRD) to dephosphorylate a kinase. Also disclosed is a method of treating a tauopathy or restless leg syndrome in a subject comprising administering to the subject an effective amount of a disclosed compound. Also disclosed are kits comprising the compounds together with instructions for treating a condition and/or a compound known for treating the condition. Finally, disclosed herein is a screening method suitable for identifying positive allosteric modulators of the ability of a receptor-type tyrosine-protein phosphatase delta (PTPRD) to dephosphorylate a kinase.
    Type: Application
    Filed: July 30, 2021
    Publication date: February 3, 2022
    Inventors: George Richard Uhl, Ian M. Henderson