Abstract: Provided herein are methods and compositions related to polyomavirus epitopes useful in the treatment of cancer or a polyomavirus infection.

Abstract: A method for fabricating an optical waveguide comprises: providing a sample of lithium niobate doped with magnesium oxide and having at least one grating of periodic domain inversion defined therein; applying a layer of metallic zinc to a surface of the sample over the at least one grating using sputter deposition; heating the sample in an atmosphere of pure oxygen to cause the zinc to indiffuse into the lithium niobate to form a waveguiding layer of increased refractive index under the surface of the sample; and using a dicing blade to cut two substantially parallel channels along a length direction of the at least one grating, to define a ridge waveguide between the two channels.

Abstract: A method of forming an optical fibre assembly, comprises providing a planar substrate made of a first material; positioning an optical fibre with an outer layer of a first glass material on a surface of the substrate to form a pre-assembly; depositing a further glass material such as silica soot onto the pre-assembly, over at least a part of the optical fibre and adjacent parts of the substrate surface; and heating the pre-assembly to consolidate the further glass material into an amorphous volume in contact with at least parts of the surface of the substrate and the outer layer of the optical fibre, thereby bonding the optical fibre to the substrate to create the optical fibre assembly.

Abstract: Provided herein are methods and compositions related to polyomavirus epitopes useful in the treatment of cancer or a polyomavirus infection.

Abstract: A method for compensating perturbed measurements comprises: obtaining measurements with respect to time of a signal representing a parameter modified by a perturbing influence and a signal representing the perturbing influence and storing the measurements for each time in a data array as parameter data and perturbation data respectively; for each of the parameter data and the perturbation data: fitting a mathematical model to the data with respect to time; determining an error between the model and the data at each time; storing the errors in the data array as normalised parameter data and normalised perturbation data respectively; fitting a mathematical model to the normalised parameter data against the normalised perturbation data to obtain a correlation function representing correlation between the parameter data and the perturbation data; using the correlation function to calculate a correction factor representing the modification of the parameter data by the perturbing influence; using the correction fac

Abstract: A method of controlling additive delivery during a bioreaction in a bioreactor comprises running a bioreaction in a bioreactor including adding additive into the bioreactor during spaced-apart feed events, where contents of the bioreactor equilibrate during a stabilisation period after a feed event; making in situ measurements of a bulk physical property of the bioreactor contents during the bioreaction to obtain process trend data; calculating a derivative of process trend data obtained over a measurement period beginning after a stabilisation period, the derivative being a metabolic rate index (MRI); and using the MRI to determine a time for starting a next feed event. A controller for a bioreactor and a bioreactor system are configured to operate according to the method.

Abstract: A method of forming an optical fibre assembly, comprises providing a planar substrate made of a first material; positioning an optical fibre with an outer layer of a first glass material on a surface of the substrate to form a pre-assembly; depositing a further glass material such as silica soot onto the pre-assembly, over at least a part of the optical fibre and adjacent parts of the substrate surface; and heating the pre-assembly to consolidate the further glass material into an amorphous volume in contact with at least parts of the surface of the substrate and the outer layer of the optical fibre, thereby bonding the optical fibre to the substrate to create the optical fibre assembly.

Abstract: A sample of nonlinear optical material for use in a nonlinear optical device contains a grating comprising alternating regions of inverted and non-inverted nonlinear coefficient of the material, with the regions separated by boundaries positioned such that the grating can provide quasi-phase matching of a selected nonlinear optical interaction, and compensate for phase mismatch arising from the Gouy phase shift of one or more focused optical beams involved in the interaction. The boundary positions can be calculated for second harmonic generation or optical parametric generation and oscillation.

Abstract: Provided by the present invention is a novel method for obtaining an 18F-labelled compound wherein said compound comprises an 18F-labelled pyridyl ring. The method of the invention is advantageous over the prior art methods as it provides these compounds in higher radiochemical yields than have been possible with previous methods. Also provided by the present invention is an 18F-labelled synthon useful in the method of the invention.

Abstract: An optical waveguide device (10) comprises a planar substrate with a lower cladding layer (14), a core layer (16) and an upper cladding layer (18), a groove (20) in the substrate that extends at least into the core layer (16), and a waveguiding channel (22) in the core layer (16), wherein at least a part of the waveguiding channel (22), which may contain a Bragg grating, is sufficiently proximate to the groove (20) in the plane of the substrate for an evanescent field of light propagating in the waveguiding channel (22) to extend laterally into the groove (20). Material contained in the groove modifies the properties of the waveguiding channel, so that a sample of material can be analysed or an active material can be used to modulate the propagating light. The groove (20) can be made before the waveguide (22). The groove (20) can be made by cutting into the substrate with a saw and the waveguide (22) can be made by direct writing in the core layer (16) with an ultraviolet beam.

Abstract: The present invention provides novel tetracyclic indole compounds of Formula (I) either as in vivo imaging agents or as therapeutic agents. A method for the preparation of the in vivo imaging agent compound is also provided by the invention, as well as a precursor for use in said method. Pharmaceutical compositions comprising the compounds of the invention are additionally provided. Where the pharmaceutical composition comprises a compound suitable for in vivo imaging, a kit is provided for the preparation of the pharmaceutical composition. In a further aspect, use of the compound for in vivo imaging or treatment of conditions associated with PBR is provided.

Abstract: Novel radiotracer(s) for Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) imaging of disease states related to altered choline metabolism (e.g., tumor imaging of prostate, breast, brain, esophageal, ovarian, endometrial, lung and prostate cancer—primary tumor, nodal disease or metastases). The present invention also describes intermediate(s), pre-cursor(s), pharmaceutical composition(s), methods of making, and methods of use of the novel radiotracer(s).

Abstract: A method, an apparatus, and a system for automatically replying a mail are provided. The method includes: receiving a new mail sent to a user; obtaining presence information of the user; searching for a mail automatic reply message corresponding to the presence information of the user; and sending the corresponding mail automatic reply message to a sender of the mail. Through the method, the apparatus, and the system, the presence information of the user is obtained, and automatic reply messages are respectively set for different presence information, so that the automatic reply messages are associated with the presence information of the user, and when a state of the user changes, the automatic reply messages are not required to be reset, thereby providing convenience for the user.

Abstract: Novel choline-derived radiotracer (s) having an isotopic carbon for Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) imaging of disease states related to altered choline metabolism (e.g., tumor imaging of prostate, breast, brain, esophageal, ovarian, endometrial, lung and prostate cancer—primary tumor, nodal disease or metastases).

Abstract: The present invention describes intermediate(s), pre-cursor(s), for the preparation of radialabelled choline analogs to be used as radiotracers for Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) imaging of diseases.

Abstract: The invention relates to novel 18F-labelled compounds which may be suitable for use as Positron Emission Tomography (PET) radiotracers, and to processes for preparation of such. The 18F-labelled compounds of the invention comprise a [18F]fluoroalkenyl group.

Abstract: A method of producing a planar substrate having waveguide channels, which method comprises: (i) providing a tube (6) of a substrate material; (ii) depositing silica layers (110) on the inside of the tube (6), the silica layers (110) being doped with a photosensitive material; (iii) drawing the tube (6) so that the cross-sectional size of the tube (109) is reduced; (iv) before or after the reducing of the cross-sectional size of the tube (6), causing the tube (6) to collapse into a flat shape by applying a low pressure to the tube, whereby the deposited silica layers together form a photosensitive silica layer (111); (v) cutting to required lengths the tube (6) which has been collapsed and reduced in cross-sectional size; and (vi) using laser writing to define waveguide channels in the cut lengths of the tube (6) and thereby to produce the planar substrate having the waveguide channels.

Abstract: The invention relates to novel 18F-labelled compounds which may be suitable for use as Positron Emission Tomography (PET) radiotracers, and to processes for preparation of such. The 18F-labelled compounds of the invention comprise a [18F]fluoroalkenyl group.

Abstract: The present invention relates to the field of [18F] radiofluorination chemistry for the preparation of Positron Emission Tomography (PET) radioligands and [18F] radiofluorinating reagents. The invention further provides kits for preparation of the same.

Abstract: A process for poling a ferroelectric material doped with a metal, which process comprises: (i) defining an electrode pattern on a ?z face of a crystal of the ferroelectric material doped with the metal; (ii) providing an electrode material; (iii) poling at a temperature of not more than 45° C.; and (iv) poling by a two-stage voltage-controlled application of electric field based on a first poling stage of domain nucleation and a second poling stage of domain spreading.