Abstract: A method of detecting an analyte in a fluid includes the step of positioning a sensor probe in the fluid. The sensor probe includes a sensing element which absorbs in the infrared region of the spectrum in response to the analyte. The change is then detected with a detection system.

Abstract: A sensor probe suited for implanting into the skin of a person includes a sensor body which may be formed from a polymer which includes 2-hydroxyethyl methacrylate (HEMA). A sensing system is supported by the body. The sensing system exhibits a detectable change when the probe is exposed to the analyte in the fluid. The sensing system may include an enzyme capable of catalyzing a reaction of the analyte to form a reaction product and a dye system which absorbs in the infrared region of the spectrum in response to the reaction product.

Abstract: A burette (10, 110, 200) suitable for delivery of a reagent into a target solution (50) employs diffusion for delivering the reagent. The reagent is in the form of a solution, which is combined with a matrix material (22), such as a gel or porous ceramic. A membrane (32) covers a delivery outlet (20) to the burette. In one embodiment, the delivery outlet comprises a plurality of fine bores (36), each one filled with or covered by a membrane (38). Stirring of the burette or target solution is achieved with a stirring means (104, 106). A heating or cooling means (80) heats a tip (16) of the burette.

Abstract: The invention relates to a novel phakic intraocular lens. The positioning arms or haptics of the lens are designed to hold the lens in position and proper orientation without engaging structures within the eye.

Abstract: The invention relates to a posterior chamber phakic intraocular lens with improved fluid flow between the anterior and posterior chambers of the eye. The fluid flow is accomplished by means of an opening situated in the center of the optical portion of the intraocular lens.

Abstract: A phakic intraocular lens includes a body having a flat anterior-facing surface and a curved posterior-facing surface that defines the optical power of the lens. The lens allows fluid to flow between the phakic lens and the iris and between the phakic lens and the natural lens. An enlarged outer rim helps maintain the position of the lens. Some embodiments are provided with openings, channels, or both at the circumferential edge of the flat anterior-facing surface or the lens body to help prevent the flat surface of the lens from sealing against the iris.

Abstract: A sensor probe suited for implanting into the skin of a person includes a sensor body which may be formed from a polymer which includes 2-hydroxyethyl methacrylate (HEMA). A sensing system is supported by the body. The sensing system exhibits a detectable change when the probe is exposed to the analyte in the fluid. The sensing system may include an enzyme capable of catalyzing a reaction of the analyte to form a reaction product and a dye system which absorbs in the infrared region of the spectrum in response to the reaction product.

Abstract: A phakic intraocular lens includes a body having a flat anterior-facing surface and a curved posterior-facing surface that defines the optical power of the lens. The lens allows fluid to flow between the phakic lens and the iris and between the phakic lens and the natural lens. An enlarged outer rim helps maintain the position of the lens. Some embodiments are provided with openings, channels, or both at the circumferential edge of the flat anterior-facing surface or the lens body to help prevent the flat surface of the lens from sealing against the iris.

Abstract: In vivo or in vitro monitoring of chemical and biochemical species (e.g., pH, or glucose levels) in the interstitial fluid of patients or in a sample of a fluid to be analyzed is provided by a probe (10, 70, 210, 270). For in vivo monitoring, the probe is readily inserted by a minimally invasive method. Optical or electrochemical sensing methods are employed to detect a physical or chemical change, such as pH, color, electrical potential, electric current, or the like, which is indicative of the concentration of the species or chemical property to be detected. Visual observation by the patient may be sufficient to monitor certain biochemicals (e.g., glucose) with this approach. A CAP membrane allows high enzyme loadings, and thus enables use of microminiature probes, and/or diagnosis of low levels of the analyte(s), with sufficient signal-to-noise ratio and low background current.

Abstract: A burette (10, 110, 200) suitable for delivery of a reagent into a target solution (50) employs diffusion for delivering the reagent. The reagent is in the form of a solution, which is combined with a matrix material (22), such as a gel or porous ceramic. A membrane (32) covers a delivery outlet (20) to the burette. In one embodiment, the delivery outlet comprises a plurality of fine bores (36), each one filled with or covered by a membrane (38). Stirring of the burette or target solution is achieved with a stirring means (104, 106). A heating or cooling means (80) heats a tip (16) of the burette.

Abstract: Disclosed are methods and devices which comprise providing a laser beam having a pre-defined shape along a beam axis and exposing a plurality of corneal regions to a plurality of asymmetrical laser beam subportions to affect the shape of said cornea without introducing any substantial asymmetry to the shape of said cornea.

Abstract: This invention is a method for sculpturing a laser beam (13) in a predetermined pattern using a device (17) between the laser source (11) and the target (23). The method comprises a series of sequential steps in which at least two regions of the cornea (177) are each exposed to increasingly larger portions of the laser beam (13). In the preferred embodiment, two pairs of complementary regions of the cornea (177) will be sequentially exposed to laser radiation. In each such region, a first part will be exposed to a substantially segmental portion of the beam (13), and then at least another larger substantially segmental portion of the beam (13) in which the larger segmental portion, includes the smaller segmental portion. In the preferred embodiment, the target (23) is the human eye, and the predetermined pattern is intended to shape the eye to treat it for astigmatism, myopia, or hyperopia.