Patents by Inventor George S. Golda
George S. Golda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6806052Abstract: An apparatus and system are provided for simultaneously analyzing a plurality of analytes anchored to microparticles. Microparticles each having a uniform population of a single kind of analyte attached are disposed as a substantially immobilized planar array inside of a flow chamber where steps of an analytical process are carried out by delivering a sequence of processing reagents to the microparticles by a fluidic system under microprocessor control. In response to such process steps, an optical signal is generated at the surface of each microparticle which is characteristic of the interaction between the analyte carried by the microparticle and the delivered processing reagent. The plurality of analytes are simultaneously analyzed by collecting and recording images of the optical signals generated by all the microparticles in the planar array.Type: GrantFiled: April 18, 2002Date of Patent: October 19, 2004Assignee: Lynx Therapeutics, Inc.Inventors: John Bridgham, Kevin P. Corcoran, George S. Golda, Michael C. Pallas, Sydney Brenner
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Publication number: 20030077615Abstract: Abstract An apparatus and system are provided for simultaneously analyzing a plurality of analytes anchored to microparticles. Microparticles each having a uniform population of a single kind of analyte attached are disposed as a substantially immobilized planar array inside of a flow chamber where steps of an analytical process are carried out by delivering a sequence of processing reagents to the microparticles by a fluidic system under microprocessor control. In response to such process steps, an optical signal is generated at the surface of each microparticle which is characteristic of the interaction between the analyte carried by the microparticle and the delivered processing reagent. The plurality of analytes are simultaneously analyzed by collecting and recording images of the optical signals generated by all the microparticles in the planar array.Type: ApplicationFiled: April 18, 2002Publication date: April 24, 2003Applicant: Lynx Therapeutics, Inc.Inventors: John Bridgham, Kevin P. Corcoran, George S. Golda, Michael C. Pallas, Sydney Brenner
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Publication number: 20020137052Abstract: An apparatus and system are provided for simultaneously analyzing a plurality of analytes anchored to microparticles. Microparticles each having a uniform population of a single kind of analyte attached are disposed as a substantially immobilized planar array inside of a flow chamber where steps of an analytical process are carried out by delivering a sequence of processing reagents to the microparticles by a fluidic system under microprocessor control. In response to such process steps, an optical signal is generated at the surface of each microparticle which is characteristic of the interaction between the analyte carried by the microparticle and the delivered processing reagent The plurality of analytes are simultaneously analyzed by collecting and recording images of the optical signals generated by all the microparticles in the planar array.Type: ApplicationFiled: July 17, 2001Publication date: September 26, 2002Applicant: Lynx Therapeutics, Inc.Inventors: John Bridgham, Kevin P. Corcoran, George S. Golda, Sydney Brenner, Michael C. Pallas
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Publication number: 20020061529Abstract: An apparatus and system are provided for simultaneously analyzing a plurality of analytes anchored to microparticles. Microparticles each having a uniform population of a single kind of analyte attached are disposed as a substantially immobilized planar array inside of a flow chamber where steps of an analytical process are carried out by delivering a sequence of processing reagents to the microparticles by a fluidic system under microprocessor control. In response to such process steps, an optical signal is generated at the surface of each microparticle which is characteristic of the interaction between the analyte carried by the microparticle and the delivered processing reagent. The plurality of analytes are simultaneously analyzed by collecting and recording images of the optical signals generated by all the microparticles in the planar array.Type: ApplicationFiled: July 17, 2001Publication date: May 23, 2002Applicant: Lynx Therapeutics, Inc.Inventors: John Bridgham, Kevin P. Corcoran, George S. Golda, Sydney Brenner, Michael C. Pallas
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Publication number: 20020051992Abstract: An apparatus and system are provided for simultaneously analyzing a plurality of analytes anchored to microparticles. Microparticles each having a uniform population of a single kind of analyte attached are disposed as a substantially immobilized planar array inside of a flow chamber where steps of an analytical process are carried out by delivering a sequence of processing reagents to the microparticles by a fluidic system under microprocessor control. In response to such process steps, an optical signal is generated at the surface of each microparticle which is characteristic of the interaction between the analyte carried by the microparticle and the delivered processing reagent. The plurality of analytes are simultaneously analyzed by collecting and recording images of the optical signals generated by all the microparticles in the planar array.Type: ApplicationFiled: July 17, 2001Publication date: May 2, 2002Applicant: Lynx Therapeutics, Inc.Inventors: John Bridgham, Kevin P. Corcoran, George S. Golda, Michael C. Pallas, Sydney Brenner
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Patent number: 5443791Abstract: A liquid-handling instrument has a worksurface with registration for modular stations to support containers of liquid, pipette apparatus with a pipette tip coupled to a sensing circuit, a robotic translation system for moving the pipette tip, and a control system with an iconic user interface for programming and editing. A gauge block registered on the worksurface provides for calibration using the sensing tip, and register cavities on the worksurface provide for modular stations. There is a wash station fop the pipette tip on the worksurface. An automated laboratory based on the liquid-handling system has heating and cooling and a sealable incubation station as well as a magnetic separation station. Methods are disclosed using the apparatus to convey droplets of liquid, to aspirate with minimum tip contamination, to mix liquids in containers, and to validate the worksurface.Type: GrantFiled: August 7, 1992Date of Patent: August 22, 1995Assignee: Perkin Elmer - Applied Biosystems DivisionInventors: G. Richard Cathcart, Thomas Brennan-Marquez, John A. Bridgham, George S. Golda, Harry A. Guiremand, Marianne Hane, Louis B. Hoff, Eric Lachenmeier, Melvyn N. Kronick, Douglas H. Keith, Paul E. Mayrand, Michael L. Metzker, William J. Mordan, Lincoln J. McBride, John Shigeura, Chen-Hanson Ting, Norman M. Whiteley