Patents by Inventor George S. Michaels

George S. Michaels has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Multidimensional microdissection and morphological reconstruction of genomic or proteomic expression activity
    Patent number: 10011864
    Abstract: A method of morphological reconstruction of biological activity in a tissue sample maps biological data resulting from analysis of tissue samples onto a 3-D morphological rendering of the biological sample. Each slice in a set of histological slices, indexed by a first index, is micro dissected into micro samples indexed by a pair of first and second indices. The indices are utilized to spatially map biological data to the 3-D rendering.
    Type: Grant
    Filed: February 16, 2011
    Date of Patent: July 3, 2018
    Assignee: Eolas Technologies Inc.
    Inventors: Michael D. Doyle, Maurice J. Pescitelli, Jr., Betsey S. Williams, George S. Michaels
  • MULTIDIMENSIONAL MORPHOLOGICAL RECONSTRUCTION OF GENOME EXPRESSION ACTIVITY
    Publication number: 20110196663
    Abstract: A method of morphological reconstruction of biological activity in a tissue sample maps biological data resulting from analysis of tissue samples onto a 3-D morphological rendering of the biological sample. Each slice in a set of histological slices, indexed by a first index, is micro dissected into micro samples indexed by a pair of first and second indices. The indices are utilized to spatially map biological data to the 3-D rendering.
    Type: Application
    Filed: February 16, 2011
    Publication date: August 11, 2011
    Inventors: Michael D. Doyle, Maurice J. Pescitelli, JR., Betsey S. Williams, George S. Michaels
  • Multidimensional morphological reconstruction of genome expression activity
    Patent number: 7894997
    Abstract: A method of morphological reconstruction of biological activity in a tissue sample maps biological data resulting from analysis of tissue samples onto a 3-D morphological rendering of the biological sample. Each slice in a set of histological slices, indexed by a first index, is micro dissected into micro samples indexed by a pair of first and second indices. The indices are utilized to spatially map biological data to the 3-D rendering.
    Type: Grant
    Filed: October 28, 2009
    Date of Patent: February 22, 2011
    Inventors: Michael D. Doyle, Maurice J. Pescitelli, Jr., Betsey S. Williams, George S. Michaels
  • MULTIDIMENSIONAL MORPHOLOGICAL RECONSTRUCTION OF GENOME EXPRESSION ACTIVITY
    Publication number: 20100049448
    Abstract: A method of morphological reconstruction of biological activity in a tissue sample maps biological data resulting from analysis of tissue samples onto a 3-D morphological rendering of the biological sample. Each slice in a set of histological slices, indexed by a first index, is micro dissected into micro samples indexed by a pair of first and second indices. The indices are utilized to spatially map biological data to the 3-D rendering.
    Type: Application
    Filed: October 28, 2009
    Publication date: February 25, 2010
    Inventors: Michael D. Doyle, Maurice J. Pescitelli, JR., Betsey S. Williams, George S. Michaels
  • Method and system for the multidimensional morphological reconstruction of genome expression activity
    Patent number: 7613571
    Abstract: A method of morphological reconstruction of biological activity in a tissue sample maps biological data resulting from analysis of tissue samples onto a 3-D morphological rendering of the biological sample. Each slice in a set of histological slices, indexed by a first index, is micro dissected into micro samples indexed by a pair of first and second indices. The indices are utilized to spatially map biological data to the 3-D rendering.
    Type: Grant
    Filed: July 27, 2001
    Date of Patent: November 3, 2009
    Inventors: Michael D. Doyle, Maurice J. Pescitelli, Jr., Betsey S. Williams, George S. Michaels
  • Method and system for the multidimensional morphological reconstruction of genome expression activity
    Publication number: 20020048766
    Abstract: A method of morphological reconstruction of biological activity in a tissue sample maps biological data resulting from analysis of tissue samples onto a 3-D morphological rendering of the biological sample. Each slice in a set of histological slices, indexed by a first index, is micro dissected into micro samples indexed by a pair of first and second indices. The indices are utilized to spatially map biological data to the 3-D rendering.
    Type: Application
    Filed: July 27, 2001
    Publication date: April 25, 2002
    Inventors: Michael D. Doyle, Maurice J. Pescitelli, Betsey S. Williams, George S. Michaels
  • DNA-binding proteins of the zinc-finger class
    Patent number: 6205404
    Abstract: The invention is directed to the design of DNA-binding proteins (DBP's) with capabilities of binding to any predetermined target double-stranded DNA sequence. Disclosed are the rules for design of the proteins; an algorithm for screening for the optimal DBP's; a computer system employing the rules and the algorithm; general formulae encompassing the proteins; and methods of use of the proteins.
    Type: Grant
    Filed: February 19, 1999
    Date of Patent: March 20, 2001
    Inventors: George S. Michaels, Raik-Hiio Mikelsaar, Richard J. Feldmann