Patents by Inventor George S. Sach

George S. Sach has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyridine compounds which have useful histamine-H.sub.2 antagonist activity
    Patent number: 4894372
    Abstract: This invention relates to 2-pyridine derivatives substituted in the 4-position with a dialkylamino- or piperidinyl- or pyrrolidinylalkyl group. The compounds have histamine H.sub.2 -antagonist activity.
    Type: Grant
    Filed: April 19, 1988
    Date of Patent: January 16, 1990
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: David G. Cooper, George S. Sach
  • 3,5-Substituted-2-pyridyl-alkylaminocyclobutenediones having histamine h.sub.1 -antagonist activity
    Patent number: 4863936
    Abstract: Various substituted aminoalkylamino-2-pyridine derivatives are disclosed which are useful as histamine H.sub.1 -antagonists.
    Type: Grant
    Filed: October 21, 1986
    Date of Patent: September 5, 1989
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: George S. Sach
  • 3,4-diamino-1,2,5-thiadiazole-1-oxides having histamine H.sub.1 -antagonist activity
    Patent number: 4771058
    Abstract: The invention relates to a class of 3,4-diamino-1,2,5-thiadiazole-1-oxides which have histamine H.sub.1 -antagonist activity. A preferred compound of the invention is 3-[3-(5-bromo-3-methylpyrid-2-ylamino)-propylamino]-4-amino-1,2,5-thiadiaz ole-1-oxide.
    Type: Grant
    Filed: June 11, 1986
    Date of Patent: September 13, 1988
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: David G. Cooper, George S. Sach
  • Pyridine derivatives and use as histamine H.sub.2 antagonists
    Patent number: 4758576
    Abstract: This invention relates to 2-pyridine derivatives substituted in the 4-position with a dialkylamino- or piperidinyl- or pyrrolidinylallyl group. The compounds have histamine H.sub.2 -antagonist activity.
    Type: Grant
    Filed: October 31, 1985
    Date of Patent: July 19, 1988
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: David G. Cooper, George S. Sach
  • Tetrahydroquinolinylalkyl amino pyridones and ring homologues thereof, useful as histamine-H.sub.1 -receptor antagonists
    Patent number: 4727076
    Abstract: The invention provides tetrahydroquinolinylalkylamino pyrimidones, and ring homologues thereof, of the general formula (1): ##STR1## wherein R.sup.1 is hydrogen or an alkyl, alkoxy, halogen or amino-substituent, m and n are each 2, 3 or 4 and R.sup.2 is hydrogen, alkyl or variously substituted benzyl.The compounds are useful as histamine-H.sub.1 -receptor antagonists.
    Type: Grant
    Filed: January 21, 1987
    Date of Patent: February 23, 1988
    Assignee: Smith Kline & French Laboratories Ltd.
    Inventors: David G. Cooper, George S. Sach
  • 2-(3-amino-5-halo-2-pyridylalkylamino)-pyrimidones useful as histamine H1-antagonists
    Patent number: 4665078
    Abstract: The invention describes 5-halo-3-amino-2-pyridyl derivatives which are useful as histamine H.sub.1 -antagonists. Particular compounds described are 2-[4-(5-bromo-3-aminopyrid-2-yl)butylamino]-5-(6-methylpyrid-3-ylmethyl)-4 -pyrimidone and 2-[4-(5-bromo-3-aminopyrid-2-yl)butylamino]-5-(N-oxopyrid-4-ylmethyl)-4-py rimidone.
    Type: Grant
    Filed: July 11, 1984
    Date of Patent: May 12, 1987
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: George S. Sach
  • 3,5-Substituted-2-pyridylalkylaminothiadiazoles having histamine H.sub.1 -antagonist activity
    Patent number: 4640926
    Abstract: 3,5-Substituted-2-pyridylalkylaminothiadiazole compounds are disclosed which are useful as histamine H.sub.1 -antagonists.
    Type: Grant
    Filed: May 17, 1985
    Date of Patent: February 3, 1987
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: George S. Sach
  • (4-aminoalkyl-2-pyridyl alkyl)guanidines
    Patent number: 4607107
    Abstract: This invention relates to 4-aminoalkyl-2-pyridyl alkylguanidines which are intermediates for pyrimidone compounds having histamine H.sub.2 -antagonist activity.
    Type: Grant
    Filed: February 17, 1984
    Date of Patent: August 19, 1986
    Assignee: Smith Kline & French Laboratories Ltd.
    Inventors: David G. Cooper, George S. Sach
  • 5-(Nitro or halogen)-3-(alkyl)-2-(aminoalkyl)pyridines
    Patent number: 4584381
    Abstract: Compounds of the formula: ##STR1## where R.sup.1 is halogen or nitro; R.sup.2 is C.sub.1-4 alkyl; and R.sup.3 is a C.sub.1-3 alkylene group are intermediates to 2-(3,5-disubstituted pyridyl-alkyl amino)-5-pyridylmethyl-4-pyrimidone derivatives which are useful as histamine H.sub.1 -antagonists.
    Type: Grant
    Filed: September 17, 1984
    Date of Patent: April 22, 1986
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: George S. Sach
  • Pyridine derivatives histamine H.sub.2 -antagonists
    Patent number: 4574126
    Abstract: This invention relates to 2-pyridine derivatives substituted in the 4-position with a dialkylamino- or piperidinyl- or pyrrolidinylalkyl group. The compounds have histamine H.sub.2 -antagonist activity.
    Type: Grant
    Filed: March 9, 1983
    Date of Patent: March 4, 1986
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: David G. Cooper, George S. Sach
  • Pyridyl-2-oxy-propyl-1H-1,2,4-triazole-3,5-diamines
    Patent number: 4551466
    Abstract: This invention relates to diaminotriazole derivatives in which one amino group is substituted by a 4-dialkylamino- or piperidinyl- or pyrolidinylmethyl pyrid-2-yloxypropyl group. The compounds have histamine H.sub.2 -antagonist activity. One specific compound is 1-methyl-N.sup.5 -3-(4-[1-piperidinomethyl]-pyridyl-2-oxy)-propyl-1H-1,2,4-triazole-3,5-dia mine.
    Type: Grant
    Filed: March 9, 1983
    Date of Patent: November 5, 1985
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: David G. Cooper, George S. Sach
  • 2-(3,5-Substituted-2-pyridylalkylamino)-5-oxopyridylmethyl-4-pyrimidones useful as histamine H.sub.1 -antagonists
    Patent number: 4537890
    Abstract: Pyridone derivatives useful as histamine H.sub.1 -antagonists are disclosed.
    Type: Grant
    Filed: November 23, 1983
    Date of Patent: August 27, 1985
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: George S. Sach
  • 2-(3,5-Substituted-2-pyridylalkylamino)-5-benzyl-4-pyrimidones
    Patent number: 4537891
    Abstract: 3,5-Disubstituted-2-pyridylalkylamino-5-optionally substituted benzyl-4-pyrimidones having histamine H.sub.1 -antagonist activity are disclosed.
    Type: Grant
    Filed: September 29, 1983
    Date of Patent: August 27, 1985
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: George S. Sach
  • 2-Aminoalkyl-pyridine derivatives
    Patent number: 4535163
    Abstract: The invention provides 2-(3,5-disubstituted pyridylalkyl amino)-5-pyridylmethyl-4-pyrimidone derivatives which are useful as histamine H.sub.1 -antagonists.
    Type: Grant
    Filed: February 2, 1984
    Date of Patent: August 13, 1985
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: George S. Sach
  • 3,5-Substituted-2-pyridylalkylamino compounds having histamine H.sub.1 -antagonist activity
    Patent number: 4532252
    Abstract: 3,5-Substituted-2-pyridylalkylamino derivatives are disclosed which are useful as histamine H.sub.1 -antagonists.
    Type: Grant
    Filed: December 9, 1983
    Date of Patent: July 30, 1985
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: George S. Sach
  • Histamine H.sub.1 -antagonists
    Patent number: 4486434
    Abstract: The invention provides 2-(3,5-disubstituted pyridylalkyl amino)-5-pyridylmethyl-4-pyrimidone derivatives which are useful as histamine H.sub.1 -antagonists.
    Type: Grant
    Filed: June 22, 1982
    Date of Patent: December 4, 1984
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: George S. Sach
  • Histamine H.sub.1 -antagonists
    Patent number: 4444772
    Abstract: The invention provides 2-(3,5-disubstituted pyridylalkyl amino)-5-pyridylmethyl-4-pyrimidone derivatives which are useful as histamine H.sub.1 -antagonists.
    Type: Grant
    Filed: June 22, 1982
    Date of Patent: April 24, 1984
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: George S. Sach
  • Pyridines
    Patent number: 4439609
    Abstract: This invention relates to 4-substituted aminomethyl pyridines with a butanamine, oxypropioamine or thiomethylamine substituent at the 2 position. The compounds are reacted with pyridones to form compounds which have histamine H.sub.2 -antagonist activity.
    Type: Grant
    Filed: February 16, 1983
    Date of Patent: March 27, 1984
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: David G. Cooper, George S. Sach
  • Alkoxypyridyl alkylamines
    Patent number: 4426526
    Abstract: The compounds are alkoxypyridine compounds which are histamine H.sub.2 -antagonists. Two specific compounds of the present invention are N-cyano-N'-methyl-N"-[2-((3-methoxy-2-pyridyl)methylthio)ethyl]guanidine and 1-methylamino-1-[2-((3-methoxy-2-pyridyl)methylthio)ethylamino]-2-nitroeth ylene.
    Type: Grant
    Filed: November 19, 1980
    Date of Patent: January 17, 1984
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham J. Durant, Charon R. Ganellin, George S. Sach
  • Pyrimidone derivatives
    Patent number: 4385058
    Abstract: This invention relates to 2-amino-4-pyrimidone derivatives, in which the amino group is substituted by a methylthioethyl, butyl or oxypropyl group bearing a terminal 4-dialkylaminomethyl-2-pyridyl group. The compounds have histamine H.sub.2 -antagonist activity. A specific compound of this invention is 2-[2-(4-dimethylaminomethyl-2-pyridylmethylthio)ethylamino]-5-(6-methyl-3- pyridylmethyl)-4-pyrimidone.
    Type: Grant
    Filed: September 16, 1981
    Date of Patent: May 24, 1983
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: David G. Cooper, George S. Sach