Patents by Inventor George S. Sheppard

George S. Sheppard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Indole-3-carbonyl and indole-3-sulfonyl derivatives as platelet activating factor antagonists
    Patent number: 5567711
    Abstract: The present invention provides compounds of formula ##STR1## and the pharmaceutically acceptable salts thereof which are potent antagonists of PAF and are useful in the treatment of PAF-related disorders including asthma, shock, respiratory distress syndrome, acute inflammation, transplanted organ rejection, gastrointestinal ulceration, allergic skin diseases, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.
    Type: Grant
    Filed: April 19, 1995
    Date of Patent: October 22, 1996
    Assignee: Abbott Laboratories
    Inventors: George S. Sheppard, Steven K. Davidsen, James B. Summers, George M. Carrera, Jr.
  • Platelet activating factor antagonists: imidazopyridine indoles
    Patent number: 5486525
    Abstract: The present invention relates to compounds of formula ##STR1## and the pharmaceutically acceptable salts thereof which are potent antagonists of PAF and are useful in the treatment of PAF-related disorders including asthma, shock, respiratory distress syndrome, acute inflammation, transplanted organ rejection, gastrointestinal ulceration, allergic skin diseases, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.
    Type: Grant
    Filed: December 5, 1994
    Date of Patent: January 23, 1996
    Assignee: Abbott Laboratories
    Inventors: James B. Summers, Jr., Steven K. Davidsen, Michael L. Curtin, H. Robin Heyman, George S. Sheppard, Lianhong Xu, George M. Carrera, Jr., Robert B. Garland
  • Platelet activating factor antagonists
    Patent number: 5459152
    Abstract: Indole compounds substituted at the 3-position by a 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]thiazole, 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]oxazole, or 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]pyrrole group are potent antagionists of PAF and are useful in the treatment of PAF-related disorders including asthma, shock, respiratory distress syndrome, acute inflammation, transplanted organ rejection, gastrointesinal ulceration, allergic skin diseases, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.
    Type: Grant
    Filed: December 2, 1993
    Date of Patent: October 17, 1995
    Assignee: Abbott Laboratories
    Inventors: James B. Summers, Steven K. Davidsen, James H. Holms, Daisy Pireh, H. Robin Heyman, Michael B. Martin, Douglas H. Steinman, George S. Sheppard, George M. Carrera, Jr.
  • Platelet activating factor antagonists
    Patent number: 5382670
    Abstract: Indole compounds substituted at the 1- or 3-position by a (pyrid-3-yl)thiazolid-4-yl)alkyl-, (pyrid-3-yl)thiazolid-4-oyl)-, (pyrid-3-yl)dithiolan-4-yl)alkyl- or (pyrid-3-yl)dithiolan-4-oyl)- group are potent inhibitors of PAF and are useful in the treatment of PAF-related disorders including septic shock, respiratory distress syndrome, acute inflammation, delayed cellular immunity, parturtition, fetal lung maturation, and cellular differentiation.
    Type: Grant
    Filed: July 7, 1993
    Date of Patent: January 17, 1995
    Assignee: Abbott Laboratories
    Inventors: James B. Summers, George S. Sheppard, James G. Phillips, Daisy Pireh, Douglas H. Steinman, Paul D. May, Denise E. Guinn, H. Robin Heyman, George M. Carrera, Jr., Steven K. Davidsen
  • Platelet activating antagonists
    Patent number: 5120749
    Abstract: Indole compounds substituted at the 1- or 3 position by a (pyrid-3 yl)thiazolid-4-yl)alkyl-, (pyrid-3-yl)thiazolid-4-oyl)-, (pyrid-3-yl)dithiolan-4-yl)alkyl- or (pyrid-3-yl) dithiolan-4-ol)- group are potent inhibitors of PAF and are useful in the treatment of PAF-related disorders including anaphylactic shock, respiratory distress syndrome, acute inflammation, delayed cellular immunity, parturtition, fetal lung maturation, and cellular differentiation.
    Type: Grant
    Filed: February 20, 1991
    Date of Patent: June 9, 1992
    Assignee: Abbott Laboratories
    Inventors: James B. Summers, George S. Sheppard, James G. Phillips, Daisy Pireh, Douglas H. Steinman, Paul D. May