Abstract: A compound of the formula ##STR1## in which R.sup.1 is hydrogen, halogen, lower alkyl, lower alkoxy or trifluoromethyl;R.sup.2 is hydrogen or lower alkyl having one to three carbon atoms; andR.sup.5 is benzyl or lower alkyl;and a compound of the formula ##STR2## in which R.sup.1 is hydrogen, halogen, lower alkyl, lower alkoxy or trifluoromethyl;R.sup.2 is hydrogen or lower alkyl having one to three carbon atoms; andX is bromo or chloro, or hydrogen;as intermediates for pyrazino(2,3-3,4) pyrido (1,2-a) indoles which are useful for treating hypertension in mammals.

Abstract: Herein is disclosed pyrazino[2',3'-3,4]pyrido[1,2-a]indole derivatives, therapeutically acceptable acid addition salts thereof, processes for their preparation, methods of using the derivatives and pharmaceutical compositions. The derivatives are useful for treating hypertension in a mammal.

Abstract: [2]Benzopyrano[4,3-c]pyridine derivatives characterized by having a 2,3,4,4a,6,10b-hexahydro-1H-[2]benzopyrano[4,3-c]pyridine nucleus are disclosed. The nucleus can be optionally further substituted at positions 2,6 and on the aromatic ring. The derivatives are useful diuretic, anorexic, antidepressant, anticonvulstant and antihypertensive agents. Methods for the preparation and use of these derivatives also are disclosed.

Abstract: Thiazinoindole derivatives characterized by having an amino(lower)alkyl radical attached to the 1 position of a 1H-1,4-thiazino[4,3-a]indole nucleus are disclosed. The amino portion of the amino(lower)alkyl radical may be further substituted with one or two lower alkyl groups or incorporated in a heterocyclic amine radical. The derivatives are substituted further at positions 1 and 10 and may be optionally substituted at positions 3, 4, 6, 7, 8 and 9. The thiazinoindole derivatives of this invention are useful antidepressant and antiulcer agents. Methods for the use of these derivatives and compositions containing them are also disclosed.

Abstract: Oxazinoindole derivatives characterized by having an amino(lower)alkyl radical attached to the 1 position of a 1H-1,4-oxazino[4,3-a]indole nucleus are disclosed. The amino portion of the amino(lower)alkyl radical may be further substituted with one or two lower alkyl groups or incorporated in a heterocyclic amine radical. The derivatives are substituted further at positions 1 and 10 and may be optionally substituted at positions 3, 4, 6, 7, 8 and 9. The oxazinoindole derivatives of this invention are useful antidepressant and antiulcer agents. Methods for the use of these derivatives and compositions containing them are also disclosed.

Abstract: Oxazinoindole derivatives characterized by having an amino(lower)alkyl radical attached to the 1 position of a 1H-1,4-oxazino[4,3-a]indole nucleus are disclosed. The amino portion of the amino(lower)alkyl radical may be further substituted with one or two lower alkyl groups or incorporated in a heterocyclic amine radical. The derivatives are substituted further at positions 1 and 10 and may be optionally substituted at positions 3, 4, 6, 7, 8 and 9. The oxazinoindole derivatives of this invention are useful antidepressant and antiulcer agents. Methods for the preparation and use of these derivatives are also disclosed.