Patents by Inventor George Searfoss

George Searfoss has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Variants of TRAF2 which act as an inhibitor of TNF-alpha (TNFalpha) signaling pathway
    Publication number: 20070015699
    Abstract: The present invention relates to variants of TRAF2 which demonstrate the ability to inhibit the TNF ? signaling pathway. In particular, applicants have isolated a splice variant of TRAF2 referred to hereinafter as “TRAF2 truncated” or “TRAF2TR” and a TRAF2 expression construct with enhanced dominant negative properties, hereafter referred to as “TRAF2 truncated-deleted” or “TRAF2TD”. Both TRAF2TR and TRAF2TD have the ability to inhibit the TNF ? signaling pathway and in TRAF2TD, this ability is greatly enhanced, greatly reducing the response to TNF ? binding.
    Type: Application
    Filed: December 5, 2005
    Publication date: January 18, 2007
    Inventors: George Searfoss, Marco Pagnoni, Yuri Ivashchenko, Kun Guo, Kenneth Clark
  • Therapeutic uses of PPAR mediators
    Publication number: 20030220373
    Abstract: Use of PPAR mediators, and their pharmaceutical compositions, as ATP binding cassette transporter 1 (ABC-1) expression modulators, wherein the PPAR ligand receptor agonists of this invention are useful as inducers of ABC-1 expression.
    Type: Application
    Filed: September 9, 2002
    Publication date: November 27, 2003
    Inventors: Michael Jaye, Nicolas Duverger, George Searfoss, Anne Minnich