Abstract: The invention relates to compounds that include peptide and peptidomimetics that inhibit estrogen receptor dependent cell proliferation. The compounds of the invention are useful for treating cell proliferative disorders or physiological conditions characterized by undesirable or unwanted estrogen induced cell proliferation, including breast cancer.

Abstract: A method and apparatus for providing radiused corners on a crack control groove is provided. A radius on the two opposing corners of the crack control groove is simultaneously formed by inserting a pilot segment of a rotating cutting blade into the groove to chase the groove with the blade. The cutting blade has side cutting segments on opposing sides of the pilot segment. The side cutting segments have a concave shape with abrasive material thereon and are located and sized to cut a predetermined radius on the opposing corners 32. Convex shaped shoulder segments inhibit the formation of a well if the blade cuts too deeply. The pilot segment advantageously has no abrasive on its sides so it does not widen the groove, and the pilot segment is shorter than the depth of the groove so it does not deepen the groove.

Abstract: A method and apparatus for providing radiused corners on a crack control groove is provided. A radius on the two opposing corners of the crack control groove is simultaneously formed by inserting a pilot segment of a rotating cutting blade into the groove to chase the groove with the blade. The cutting blade has side cutting segments on opposing sides of the pilot segment. The side cutting segments have a concave shape with abrasive material thereon and are located and sized to cut a predetermined radius on the opposing corners 32. Convex shaped shoulder segments inhibit the formation of a well if the blade cuts too deeply. The pilot segment advantageously has no abrasive on its sides so it does not widen the groove, and the pilot segment is shorter than the depth of the groove so it does not deepen the groove.