Patents by Inventor George Sigal

George Sigal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Integrated Consumable Data Management System & Platform
    Publication number: 20190391170
    Abstract: The present invention relates to methods, devices and systems for associating consumable data with an assay consumable used in a biological assay. Provided are assay systems and associated consumables, wherein the assay system adjusts one or more steps of an assay protocol based on consumable data specific for that consumable. Various types of consumable data are described, as well as methods of using such data in the conduct of an assay by an assay system. The present invention also relates to consumables (e.g., kits and reagent containers), software, data deployable bundles, computer-readable media, loading carts, instruments, systems, and methods, for performing automated biological assays.
    Type: Application
    Filed: January 20, 2017
    Publication date: December 26, 2019
    Applicant: Meso Scale Technologies, LLC.
    Inventors: Manish KOCHAR, Peter J. BOSCO, Ian D. CHAMBERLIN, Bandele JEFFREY-COKER, Eric M. JONES, Gary l. KRIVOY, Aaron H. LEIMKUEHLER, Pei-Ming WU, Kim-Xuan NGUYEN, Pankaj OBEROI, Louis W. PANG, Jennifer PARKER, Victor PELLICIER, Nick SAMMONS, George SIGAL, Jacob WOHLSTADTER, Mike VOCK, Stanley T. SMITH, Carl C. STEVENS, Roger D. OSBORNE, Kenneth PAGE, Michael T. WADE, Jon WILLOUGHBY, Lei WANG, Don E. KRUEGER
  • Biodosimetry panels and methods
    Patent number: 10436784
    Abstract: The present invention relates to methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. The invention also relates to algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.
    Type: Grant
    Filed: September 15, 2015
    Date of Patent: October 8, 2019
    Assignees: Meso Scale Technologies, LLC, The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
    Inventors: William F Blakely, Eli N. Glezer, John Kenten, Sudeep Kumar, Anu Mathew, Natalia I. Ossetrova, George Sigal
  • METHODS FOR CONDUCTING MULTIPLEXED ASSAYS
    Publication number: 20190291103
    Abstract: The invention relates to methods for conducting solid-phase binding assays. One example is an assay method having improved analyte specificity where specificity is limited by the presence of non-specific binding interactions.
    Type: Application
    Filed: December 20, 2018
    Publication date: September 26, 2019
    Applicant: Meso Scale Technologies, LLC.
    Inventors: Eli N. Glezer, Sudeep Kumar, Pankaj Oberoi, George Sigal, Michael Tsionsky
  • ASSAY APPARATUSES, METHODS AND REAGENTS
    Publication number: 20190277855
    Abstract: We describe apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.
    Type: Application
    Filed: May 23, 2019
    Publication date: September 12, 2019
    Inventors: Charles M. CLINTON, Eli N. GLEZER, Bandele JEFFREY-COKER, Sandor L. KOVACS, Sudeep M. KUMAR, George SIGAL, Carl STEVENS, Michael VOCK
  • Assay methods
    Patent number: 10408823
    Abstract: The present invention is directed to methods for improving assay specificity and performance in binding assays.
    Type: Grant
    Filed: May 15, 2015
    Date of Patent: September 10, 2019
    Assignee: Meso Scale Technologies, LLC.
    Inventors: Anahit Aghvanyan, Eli N. Glezer, John Kenten, George Sigal, Martin Stengelin, David Routenberg
  • METHODS AND APPARATUS FOR CONDUCTING MULTIPLE MEASUREMENTS ON A SAMPLE
    Publication number: 20190257823
    Abstract: Multiplexed test measurements are conducted using an assay module having a plurality of assay domains. In preferred embodiments, these measurements are conducted in assay modules having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.
    Type: Application
    Filed: May 2, 2019
    Publication date: August 22, 2019
    Applicant: Meso Scale Technologies, LLC.
    Inventors: Eli N. Glezer, Kent Johnson, Michael Tsionsky, John H. Kenten, Jeff D. Debad, Robert M. Umek, Paula Denney Eason, Hans Biebuyck, Jacob N. Wohlstadter, James Wilbur, George Sigal, Niranjan Y. Sardesai
  • Assay Apparatuses, Methods and Reagents
    Publication number: 20190219794
    Abstract: Apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation are described. They are particularly well suited for conducting automated analysis in a multi-well plate assay format.
    Type: Application
    Filed: March 21, 2019
    Publication date: July 18, 2019
    Inventors: Ian Chamberlin, Charlles M. Clinton, Eli N. Glezer, Bandele Jeffrey-Coker, Manish Kochar, Sandor Kovacs, D.T. Le, Aaron Leimkuehler, George Sigal, Leo Tabakin, Jon Willoughby
  • CONTINUOUS INTERLEAVED PROCESS FOR CONDUCTING AN ASSAY IN A MULTI-WELL PLATE
    Publication number: 20190187060
    Abstract: We describe apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.
    Type: Application
    Filed: February 7, 2019
    Publication date: June 20, 2019
    Inventors: Charles M. CLINTON, Eli N. GLEZER, Sharon WEST, George SIGAL, Carl STEVENS, Michael L. VOCK
  • Assay Cartridges and Methods of Using the Same
    Publication number: 20190178787
    Abstract: Assay cartridges are described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain embodiments, these cartridges are adapted to receive and analyze a sample collected on an applicator stick. Also described are kits including such cartridges and a cartridge reader configured to analyze an assay conducted using an assay cartridge.
    Type: Application
    Filed: December 13, 2018
    Publication date: June 13, 2019
    Inventors: Nicholas Anderson, Jeffery Debad, Eli N. Glezer, Sudeep Kumar, Noel Lawrence, Kenneth Page, George Sigal, Sharon West
  • Assay apparatuses, methods and reagents
    Patent number: 10302649
    Abstract: We describe apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.
    Type: Grant
    Filed: December 21, 2006
    Date of Patent: May 28, 2019
    Assignee: Meso Scale Technologies, LLC
    Inventors: Charles M. Clinton, Eli N. Glezer, Bandele Jeffrey-Coker, Sandor L. Kovacs, Sudeep M. Kumar, George Sigal, Carl Stevens, Michael Vock
  • Serology assays
    Patent number: 10295539
    Abstract: The invention provides methods and kits for measuring the ability of a test sample to inhibit the binding of a receptor expressed by a pathogen to a host cell ligand of the pathogen.
    Type: Grant
    Filed: April 18, 2011
    Date of Patent: May 21, 2019
    Assignee: MESO SCALE TECHNOLOGIES, LLC.
    Inventor: George Sigal
  • Assay apparatuses, methods and reagants
    Patent number: 10281678
    Abstract: Apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation are described. They are particularly well suited for conducting automated analysis in a multi-well plate assay format.
    Type: Grant
    Filed: January 3, 2014
    Date of Patent: May 7, 2019
    Assignee: Meso Scale Technologies, LLC
    Inventors: Ian Chamberlin, Charles M. Clinton, Eli N. Glezer, Bandele Jeffrey-Coker, Manish Kochar, Sandor Kovacs, D. T. Le, Aaron Leimkuehler, George Sigal, Leo Tabakin, Jon Willoughby
  • Serology assays
    Patent number: 10241112
    Abstract: The invention provides methods and kits for measuring the ability of a test sample to inhibit the binding of a receptor expressed by a pathogen to a host cell ligand of the pathogen.
    Type: Grant
    Filed: May 22, 2014
    Date of Patent: March 26, 2019
    Assignee: MESO SCALE TECHNOLOGIES, LLC.
    Inventor: George Sigal
  • METHODS FOR CONDUCTING MULTIPLEXED ASSAYS
    Publication number: 20190083976
    Abstract: The invention relates to methods for conducting solid-phase binding assays. One example is an assay method having improved analyte specificity where specificity is limited by the presence of non-specific binding interactions.
    Type: Application
    Filed: December 5, 2018
    Publication date: March 21, 2019
    Applicant: Meso Scale Technologies, LLC
    Inventors: Eli N. Glezer, Sudeep Kumar, Pankaj Oberoi, George Sigal, Michael Tsionsky
  • Continuous interleaved process for conducting an assay in a multi-well plate
    Patent number: 10203286
    Abstract: We describe a method for conducting an assay in a multi-well assay plate using an apparatus comprising a light detection subsystem, a liquid handling subsystem, and a plate handling subsystem. This is particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, it may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.
    Type: Grant
    Filed: April 10, 2009
    Date of Patent: February 12, 2019
    Assignee: Meso Scale Diagnostics, LLC
    Inventors: Charles M. Clinton, Eli N. Glezer, Sharon West, George Sigal, Carl Stevens, Michael L. Vock
  • Methods for conducting multiplexed assays
    Patent number: 10201812
    Abstract: The invention relates to methods for conducting solid-phase binding assays. One example is an assay method having improved analyte specificity where specificity is limited by the presence of non-specific binding interactions.
    Type: Grant
    Filed: October 16, 2017
    Date of Patent: February 12, 2019
    Assignee: Meso Scale Technologies, LLC.
    Inventors: Eli N. Glezer, Sudeep Kumar, Pankaj Oberoi, George Sigal, Michael Tsionsky
  • Methods for conducting multiplexed assays
    Patent number: 10189023
    Abstract: The invention relates to methods for conducting solid-phase binding assays. One example is an assay method having improved analyte specificity where specificity is limited by the presence of non-specific binding interactions.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: January 29, 2019
    Assignee: MESO SCALE TECHOLOGIES, LLC.
    Inventors: Eli N. Glezer, Sudeep Kumar, Pankaj Oberoi, George Sigal, Michael Tsionsky
  • Assay cartridges and method of using the same
    Patent number: 10184884
    Abstract: Assay cartridges are described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain embodiments, these cartridges are adapted to receive and analyze a sample collected on an applicator stick. Also described are kits including such cartridges and a cartridge reader configured to analyze an assay conducted using an assay cartridge.
    Type: Grant
    Filed: December 3, 2010
    Date of Patent: January 22, 2019
    Assignee: Meso Scale Technologies, LLC
    Inventors: Nicholas Anderson, Jeffery Debad, Eli N. Glezar, Sudeep Kumar, Noel Lawrence, Kenneth Page, George Sigal, Sharon West
  • MULTIPLEXED ASSAY KITS FOR EVALUATION OF SYSTEMIC LUPUS ERYTHEMATOSUS
    Publication number: 20180348217
    Abstract: The present invention relates to methods of diagnosing lupus in a patient, as well as methods of monitoring the progression of lupus and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.
    Type: Application
    Filed: August 3, 2018
    Publication date: December 6, 2018
    Applicant: Meso Scale Technologies, LLC
    Inventors: Eli N. Glezer, Mikayla Higgins, John Kenten, George Sigal
  • BIODOSIMETRY PANELS AND METHODS
    Publication number: 20180246100
    Abstract: The present invention relates to methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. The invention also relates to algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.
    Type: Application
    Filed: February 22, 2018
    Publication date: August 30, 2018
    Applicants: Meso Scale Technologies, LLC., THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.
    Inventors: William F. Blakely, Eli N. Glezer, John Kenten, Sudeep Kumar, Anu Mathew, Natalia I. Ossetrova, George Sigal