Patents by Inventor George Terrance Walker
George Terrance Walker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10876162Abstract: The present invention provide methods using genes associated with multi-drug resistance for rapidly detecting a patient colonized or infected with an multi-drug resistant organism and administrating the appropriate precautions and/or treatment.Type: GrantFiled: August 6, 2018Date of Patent: December 29, 2020Assignee: OPGEN, INC.Inventors: George Terrance Walker, Tony Rockweiler, Alex Saeed, Vadim Sapiro, Rossio Kersey
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Publication number: 20200286590Abstract: Systems, apparatus, and methods are disclosed for generating a resistome profile for a subject, monitoring an infection state of one or more subjects, and/or identifying a potential infection outbreak at a facility, for example, by obtaining first data representative of at least one measure of antibiotic resistance of an organism from a first sample, identifying the organism, determining at least one of an antibiotic susceptibility phenotype, an identity of an antibiotic resistance gene, and an antibiotic to which the organism is non-susceptible, generating and comparing a first pattern to at least one known pattern to determine and generate a profile uniqueness identifier indicating a degree of similarity above a threshold between the first pattern and the at least one known pattern.Type: ApplicationFiled: November 11, 2019Publication date: September 10, 2020Applicant: OpGen, Inc.Inventors: Evan Jones, Vadim Sapiro, George Terrance Walker, Alex Saeed
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Patent number: 10475526Abstract: Systems, apparatus, and methods are disclosed for generating a resistome profile for a subject, monitoring an infection state of one or more subjects, and/or identifying a potential infection outbreak at a facility, for example, by obtaining first data representative of at least one measure of antibiotic resistance of an organism from a first sample, identifying the organism, determining at least one of an antibiotic susceptibility phenotype, an identity of an antibiotic resistance gene, and an antibiotic to which the organism is non-susceptible, generating and comparing a first pattern to at least one known pattern to determine and generate a profile uniqueness identifier indicating a degree of similarity above a threshold between the first pattern and the at least one known pattern.Type: GrantFiled: May 27, 2015Date of Patent: November 12, 2019Assignee: OpGen, Inc.Inventors: Evan Jones, Vadim Sapiro, George Terrance Walker, Alex Saeed
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Publication number: 20180342310Abstract: The present invention provide methods using genes associated with multi-drug resistance for rapidly detecting a patient colonized or infected with an multi-drug resistant organism and administrating the appropriate precautions and/or treatment.Type: ApplicationFiled: August 6, 2018Publication date: November 29, 2018Inventors: George Terrance Walker, Tony Rockweiler, Alex Saeed, Vadim Sapiro, Rossio Kersey
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Publication number: 20170253917Abstract: The present invention provides methods, systems, and kits for determining an appropriate therapeutic regimen for treating an infection caused by antibiotic resistant bacteria.Type: ApplicationFiled: March 7, 2017Publication date: September 7, 2017Inventors: George Terrance WALKER, Tony ROCKWEILER
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Publication number: 20160085912Abstract: Systems, apparatus, and methods are disclosed for generating a resistome profile for a subject, monitoring an infection state of one or more subjects, and/or identifying a potential infection outbreak at a facility, for example, by obtaining first data representative of at least one measure of antibiotic resistance of an organism from a first sample, identifying the organism, determining at least one of an antibiotic susceptibility phenotype, an identity of an antibiotic resistance gene, and an antibiotic to which the organism is non-susceptible, generating and comparing a first pattern to at least one known pattern to determine and generate a profile uniqueness identifier indicating a degree of similarity above a threshold between the first pattern and the at least one known pattern.Type: ApplicationFiled: May 27, 2015Publication date: March 24, 2016Inventors: Evan JONES, Vadim SAPIRO, George Terrance WALKER, Alex SAEED
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Publication number: 20160053219Abstract: Systems, methods, and devices are disclosed for improved temperature control, particularly within a predetermined range of temperatures near or above varying ambient temperatures. Previously-unrealized advantages are recognized for maintaining samples, particularly medical and/or biological specimens, at a temperature within a predetermined range of temperatures near or above ambient temperature that selectively promote and/or selectively inhibit organism growth, organism viability, biochemical reactions, and/or chemical reactions. Systems, methods, and devices may include at least phase change material selected and configured to maintain a sample at a predetermined temperature range between about 22° Celsius and about 100° Celsius during a predetermined time period.Type: ApplicationFiled: August 25, 2015Publication date: February 25, 2016Inventors: George Terrance Walker, Tony Rockweiler
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Publication number: 20150259729Abstract: The present invention provide methods using genes associated with multi-drug resistance for rapidly detecting a patient colonized or infected with an multi-drug resistant organism and administrating the appropriate precautions and/or treatment.Type: ApplicationFiled: March 13, 2015Publication date: September 17, 2015Inventors: George Terrance Walker, Tony Rockweiler, Alex Saeed, Vadim Sapiro, Rossio Kersey
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Publication number: 20030104430Abstract: Described and disclosed are devices, methods, and compositions of matter for the multiplex amplification and analysis of nucleic acid sequences in a sample using novel strand displacement amplification technologies in combination with bioelectronic microchip technology. Specifically, a nucleic acid in a sample is amplified to form amplicons, the amplicons are addressed to specified electronically addressable capture sites of the bioelectronic microchip, the addressed amplicons are captured and labeled, and then the capture sites are analyzed for the presence of label. Samples may be amplified using strand displacement amplification. The invention is also amenable to other amplification methodologies well known by those skilled in the art. The capture and label steps may be by a method of universal capture with sequence specific reporter, or by a method of sequence specific capture with universal reporter.Type: ApplicationFiled: July 15, 2002Publication date: June 5, 2003Inventors: Michael I. Nerenberg, Carl F. Edman, Catherine A. Spargo, George Terrance Walker
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Patent number: 5744311Abstract: Strand Displacement Amplification methods (thermophilic SDA) which can be performed over a broad temperature range (37.degree. C. to 70.degree. C.). The preferred temperature range for thermophilic SDA is 50.degree. C. to 70.degree. C. It has been found that certain thermophilic restriction endonucleases are capable of nicking the hemimodified restriction endonuclease recognition/cleavage site as required by SDA and dissociating from the site. It has further been found that certain thermophilic polymerases are capable of extending from the nick while displacing the downstream strand. Thermophilic SDA, because of reaction temperatures higher than previously possible with conventional SDA enzyme systems, has improved specificity and efficiency, reduced nonspecific background amplification, and potentially improved yields of amplification products.Type: GrantFiled: August 22, 1996Date of Patent: April 28, 1998Assignee: Becton, Dickinson and CompanyInventors: Melinda S. Fraiser, Catherine A. Spargo, George Terrance Walker, Mark Van Cleve, David James Wright, Michael C. Little
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Patent number: 5736365Abstract: Primers and methods for adapter-mediated multiplex amplification of the IS6110 insertion element of Mycobacterium tuberculosis (M.tb) and the 16S ribosomal gene of Mycobacterium tuberculosis, useful for simultaneously detecting and/or identifying species of the M. tuberculosis complex and other clinically relevant Mycobacterium species. Multiplex Strand Displacement Amplification (SDA) is used in a single amplification reaction which is capable of simultaneously identifying M. tuberculosis and providing a screen for substantially all of the clinically relevant species of Mycobacteria. Also disclosed are methods for adapter-mediated multiplex amplification of multiple target sequences and a single internal control sequence for determination of sample efficacy or quantitation of the targets.Type: GrantFiled: August 29, 1996Date of Patent: April 7, 1998Assignee: Becton, Dickinson and CompanyInventors: George Terrance Walker, James G. Nadeau, Patricia Anne Spears, Colleen M. Nycz, Daryl Dee Shank, James L. Schram, Stewart Russel Jurgensen
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Patent number: 5712124Abstract: This invention relates a nucleic acid target amplification and detection method which operates at a single temperature and makes use of a polymerase in conjunction with an endonuclease that will nick the polymerized strand such that the polymerase will displace the strand without digestion while generating a newly polymerized strand.Type: GrantFiled: January 18, 1995Date of Patent: January 27, 1998Assignee: Becton, Dickinson and CompanyInventor: George Terrance Walker
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Patent number: 5702926Abstract: .alpha.-Boronated deoxynucleoside triphosphates, when incorporated into a double-stranded restriction endonuclease recognition/cleavage site for a restriction endonuclease, induce nicking by the restriction endonuclease. .alpha.-Boronated deoxynucleoside triphosphates (dNTP.alpha.BH.sub.3) are therefore useful as nucleotide analogs in SDA to produce the nickable hemimodified restriction endonuclease recognition/cleavage site required to sustain the amplification reaction.Type: GrantFiled: August 22, 1996Date of Patent: December 30, 1997Assignee: Becton, Dickinson and CompanyInventors: Melinda S. Fraiser, George Terrance Walker
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Patent number: 5648211Abstract: Strand Displacement Amplification methods (thermophilic SDA) which can be performed over a broad temperature range (37.degree. C. to 70.degree. C.). The preferred temperature range for thermophilic SDA is 50.degree. C. to 70.degree. C. It has been found that certain thermophilic restriction endonucleases are capable of nicking the hemimodified restriction endonuclease recognition/cleavage site as required by SDA and dissociating from the site. It has further been found that certain thermophilic polymerases are capable of extending from the nick while displacing the downstream strand. Thermophilic SDA, because of reaction temperatures higher than previously possible with conventional SDA enzyme systems, has improved specificity and efficiency, reduced nonspecific background amplification, and potentially improved yields of amplification products.Type: GrantFiled: April 18, 1994Date of Patent: July 15, 1997Assignee: Becton, Dickinson and CompanyInventors: Melinda S. Fraiser, Catherine A. Spargo, George Terrance Walker, Mark Van Cleve, David James Wright, Michael C. Little