Patents by Inventor George Todd MILNE

George Todd MILNE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • sGC STIMULATORS
    Publication number: 20230106002
    Abstract: Compounds of Formulae I? and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
    Type: Application
    Filed: December 20, 2021
    Publication date: April 6, 2023
    Inventors: Takashi Nakai, Joel Moore, Nicholas Robert Perl, Rajesh R. Iyengar, Ara Mermerian, G-Yoon Jamie Im, Thomas Wai-Ho Lee, Colleen Hudson, Glen Robert Rennie, Lei Jia, Paul Allan Renhowe, Timothy Claude Barden, Xiang Y. Yu, James Edward Sheppeck, Karthik Iyer, Joon Jung, George Todd Milne, Kimberly Kafadar Long, Mark G. Currie
  • sGC stimulators
    Patent number: 11207323
    Abstract: Compounds of Formulae I? and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
    Type: Grant
    Filed: March 13, 2020
    Date of Patent: December 28, 2021
    Assignee: Cyclerion Therapeutics, Inc.
    Inventors: Takashi Nakai, Joel Moore, Nicholas Robert Perl, Rajesh R. Iyengar, Ara Mermerian, G-Yoon Jamie Im, Thomas Wai-Ho Lee, Colleen Hudson, Glen Robert Rennie, Lei Jia, Paul Allan Renhowe, Timothy Claude Barden, Xiang Y. Yu, James Edward Sheppeck, Karthik Iyer, Joon Jung, George Todd Milne, Kimberly Kafadar Long, Mark G. Currie
  • sGC STIMULATORS
    Publication number: 20210214364
    Abstract: The present patent application discloses at least the compounds according to Formula l shown below, or pharmaceutically acceptable salts thereof, wherein ringjB,n, JD, J,0, X, X1, J, RC, and W are as defined herein. These compounds are useful as simulators of soluble sGC.
    Type: Application
    Filed: December 15, 2020
    Publication date: July 15, 2021
    Inventors: Paul Allan Renhowe, James Edward Sheppeck, Takashi Nakai, Karthik Iyer, Nicholas Robert Perl, Glen Robert Rennie, Mark G. Currie, Kimberly Kafadar Long, George Todd Milne, Rajesh R. Iyengar
  • sGC STIMULATORS
    Publication number: 20200316065
    Abstract: Compounds of Formulae I? and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
    Type: Application
    Filed: March 13, 2020
    Publication date: October 8, 2020
    Inventors: Takashi Nakai, Joel Moore, Nicholas Robert Perl, Rajesh R. Iyengar, Ara Mermerian, G-Yoon Jamie Im, Thomas Wai-Ho Lee, Colleen Hudson, Glen Robert Rennie, Lei Jia, Paul Allan Renhowe, Timothy Claude Barden, Xiang Y. Yu, James Edward Sheppeck, Karthik Iyer, Joon Jung, George Todd Milne, Kimberly Kafadar Long, Mark G. Currie
  • sGC stimulators
    Patent number: 10639308
    Abstract: Compounds of Formulae I? and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
    Type: Grant
    Filed: November 2, 2018
    Date of Patent: May 5, 2020
    Assignee: Cyclerion Therapeutics, Inc.
    Inventors: Takashi Nakai, Joel Moore, Nicholas Robert Perl, Rajesh R. Iyengar, Ara Mermerian, G-Yoon Jamie Im, Thomas Wai-Ho Lee, Colleen Hudson, Glen Robert Rennie, Lei Jia, Paul Allan Renhowe, Timothy Claude Barden, Xiang Y. Yu, James Edward Sheppeck, Karthik Iyer, Joon Jung, George Todd Milne, Kimberly Kafadar Long, Mark G. Currie
  • sGC stimulators
    Patent number: 10517874
    Abstract: Compounds of Formulae I? and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
    Type: Grant
    Filed: January 16, 2017
    Date of Patent: December 31, 2019
    Assignee: Cyclerion Therapeutics, Inc.
    Inventors: Takashi Nakai, Joel Moore, Nicholas Robert Perl, Rajesh R. Iyengar, Ara Mermerian, G-Yoon Jamie Im, Thomas Wai-Ho Lee, Colleen Hudson, Glen Robert Rennie, Paul Allan Renhowe, Timothy Claude Barden, Xiang Y. Yu, James Edward Sheppeck, Karthik Iyer, Joon Jung, George Todd Milne, Kimberly Kafadar Long, Mark G. Currie, James Jia
  • sGC STIMULATORS
    Publication number: 20190167679
    Abstract: Compounds of Formulae I? and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
    Type: Application
    Filed: November 2, 2018
    Publication date: June 6, 2019
    Inventors: Takashi Nakai, Joel Moore, Nicholas Robert Perl, Rajesh R. Iyengar, Ara Mermerian, G-Yoon Jamie Im, Thomas Wai-Ho Lee, Colleen Hudson, Glen Robert Rennie, James Jia, Paul Allan Renhowe, Timothy Claude Barden, Xiang Y. Yu, James Edward Sheppeck, Karthik Iyer, Joon Jung, George Todd Milne, Kimberly Kafadar Long, Mark G. Currie
  • sGC stimulators
    Patent number: 10183021
    Abstract: Compounds of Formulae I? and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
    Type: Grant
    Filed: August 24, 2016
    Date of Patent: January 22, 2019
    Assignee: Ironwood Pharmaceuticals, Inc.
    Inventors: Takashi Nakai, James Jia, Paul Allan Renhowe, Timothy Claude Barden, Xiang Y. Yu, James Edward Sheppeck, Karthik Iyer, Joon Jung, George Todd Milne, Kimberly Kafadar Long, Mark G. Currie, Joel Moore, Nicholas Robert Perl, Rajesh R. Iyengar, Ara Mermerian, G-Yoon Jamie Im, Thomas Wai-Ho Lee, Colleen Hudson, Glen Robert Rennie
  • sGC STIMULATORS
    Publication number: 20170137439
    Abstract: Compounds of Formulae I? and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
    Type: Application
    Filed: January 16, 2017
    Publication date: May 18, 2017
    Applicant: Ironwood Pharmaceuticals, Inc.
    Inventors: Takashi NAKAI, Joel MOORE, Nicholas Robert PERL, Rajesh R. IYENGAR, Ara MERMERIAN, G-Yoon Jamie IM, Thomas Wai-Ho LEE, Colleen HUDSON, Glen Robert RENNIE, James JIA, Paul Allan RENHOWE, Timothy Claude BARDEN, Xiang Y. YU, James Edward SHEPPECK, Karthik IYER, Joon JUNG, George Todd MILNE, Kimberly Kafadar LONG, Mark G. CURRIE
  • sGC STIMULATORS
    Publication number: 20170136019
    Abstract: Compounds of Formulae I? and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
    Type: Application
    Filed: January 16, 2017
    Publication date: May 18, 2017
    Applicant: Ironwood Pharmaceuticals, Inc.
    Inventors: Takashi NAKAI, Joel MOORE, Nicholas Robert PERL, Rajesh R. IYENGAR, Ara MERMERIAN, G-Yoon Jamie IM, Thomas Wai-Ho LEE, Colleen HUDSON, Glen Robert RENNIE, James JIA, Paul Allan RENHOWE, Timothy Claude BARDEN, Xiang Y. YU, James Edward SHEPPECK, Karthik IYER, Joon JUNG, George Todd MILNE, Kimberly Kafadar LONG, Mark G. CURRIE
  • sGC stimulators
    Patent number: 9586937
    Abstract: Compounds of Formulae I? and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
    Type: Grant
    Filed: July 21, 2016
    Date of Patent: March 7, 2017
    Assignee: IRONWOOD PHARMACEUTICALS, INC.
    Inventors: Takashi Nakai, Joel Moore, Nicholas Robert Perl, Rajesh R. Iyengar, Ara Mermerian, G-Yoon Jamie Im, Thomas Wai-Ho Lee, Colleen Hudson, Glen Robert Rennie, James Jia, Paul Allan Renhowe, Timothy Claude Barden, Xiang Y. Yu, James Edward Sheppeck, Karthik Iyer, Joon Jung, George Todd Milne, Kimberly Kafadar Long, Mark G. Currie
  • sGC STIMULATORS
    Publication number: 20160375022
    Abstract: Compounds of Formulae I? and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
    Type: Application
    Filed: August 24, 2016
    Publication date: December 29, 2016
    Applicant: Ironwood Pharmaceuticals, Inc.
    Inventors: Takashi NAKAI, Joel MOORE, Nicholas Robert PERL, Rajesh R. IYENGAR, Ara MERMERIAN, G-Yoon Jamie IM, Thomas Wai-Ho LEE, Colleen HUDSON, Glen Robert RENNIE, James JIA, Paul Allan RENHOWE, Timothy Claude BARDEN, Xiang Y. YU, James Edward SHEPPECK, Karthik IYER, Joon JUNG, George Todd MILNE, Kimberly Kafadar LONG, Mark G. CURRIE
  • sGC STIMULATORS
    Publication number: 20160347738
    Abstract: Compounds of Formulae I? and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
    Type: Application
    Filed: July 21, 2016
    Publication date: December 1, 2016
    Inventors: Takashi NAKAI, Joel MOORE, Nicholas Robert PERL, Rajesh R. IYENGAR, Ara MERMERIAN, G-Yoon Jamie IM, Thomas Wai-Ho LEE, Colleen HUDSON, Glen Robert RENNIE, James JIA, Paul Allan RENHOWE, Timothy Claude BARDEN, Xiang Y. YU, James Edward SHEPPECK, Karthik IYER, Joon JUNG, George Todd MILNE, Kimberly Kafadar LONG, Mark G. CURRIE
  • USE OF SGC STIMULATORS FOR THE TREATMENT OF NEUROMUSCULAR DISORDERS
    Publication number: 20160324856
    Abstract: The present disclosure relates to methods, uses, pharmaceutical compositions and kits comprising a sGC stimulator or a pharmaceutically acceptable salt thereof, alone or in combination with one or more additional therapeutic agents, for the treatment of a neuromuscular disorder associated with loss or alteration of function of nitric oxide synthase (NOS).
    Type: Application
    Filed: January 13, 2015
    Publication date: November 10, 2016
    Inventors: Kimberly Kafadar LONG, George Todd MILNE, Mark G. CURRIE
  • sGC stimulators
    Patent number: 9481689
    Abstract: Compounds of Formulae I? and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: November 1, 2016
    Assignee: IRONWOOD PHARMACEUTICALS, INC.
    Inventors: Takashi Nakai, Joel Moore, Nicholas Robert Perl, Rajesh R. Iyengar, Ara Mermerian, G-Yoon Jamie Im, Thomas Wai-Ho Lee, Colleen Hudson, Glen Robert Rennie, James Jia, Paul Allan Renhowe, Timothy Claude Barden, Xiang Y. Yu, James Edward Sheppeck, Karthik Iyer, Joon Jung, George Todd Milne, Kimberly Kafadar Long, Mark G. Currie
  • SGC STIMULATORS
    Publication number: 20160311826
    Abstract: The present patent application discloses at least the compounds according to Formula I shown below, or pharmaceutically acceptable salts thereof, wherein ring JB, n, JD, J, o, X, X1, J, RC, and W are as defined herein. These compounds are useful as stimulators of soluble sGC.
    Type: Application
    Filed: December 10, 2014
    Publication date: October 27, 2016
    Inventors: Paul Allan RENHOWE, James Edward SHEPPECK, Takashi NAKAI, Karthik IYER, Nicholas Robert PERL, Glen Robert RENNIE, Mark G. CURRIE, Kimberly Kafadar LONG, George Todd MILNE, Rajesh R. IYENGAR
  • sGC STIMULATORS
    Publication number: 20160031903
    Abstract: Compounds of Formulae I? and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
    Type: Application
    Filed: March 14, 2014
    Publication date: February 4, 2016
    Applicant: IRONWOOD PHARMACEUTICALS, INC.
    Inventors: Takashi NAKAI, Joel MOORE, Nicholas Robert PERL, Rajesh R. IYENGAR, Ara MERMERIAN, G-Yoon Jamie IM, Thomas Wai-Ho LEE, Colleen HUDSON, Glen Robert RENNIE, James JIA, Paul Allan RENHOWE, Timothy Claude BARDEN, Xiang Y. YU, James Edward SHEPPECK, Karthik IYER, Joon JUNG, George Todd MILNE, Kimberly Kafadar LONG