Patents by Inventor George Tuszynski

George Tuszynski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for inhibiting angiogenesis
    Publication number: 20070128196
    Abstract: Methods for inhibiting angiogenesis in endothelial cells and selectively inducing apoptosis in endothelial cells via compounds which binds annexin II are provided. These compounds and methods for using these compounds are useful in the treatment of diseases or disorders characterized by unwanted angiogenesis. Also provided are pharmaceutical compositions containing a compound which binds annexin II and a pharmaceutically acceptable vehicle and methods for identifying such compounds.
    Type: Application
    Filed: January 5, 2007
    Publication date: June 7, 2007
    Inventors: Mahesh Sharma, George Tuszynski
  • Angiocidin: a Cys-Ser-Val-Thr-Cys-Gly specific tumor cell adhesion receptor
    Publication number: 20030180295
    Abstract: The present invention provides the sequence of a cell matrix receptor specific for the Cys-Ser-Val-Thr-Cys-Gly (SEQ ID NO: 1) region of thrombospondin. Also provided are purification, cloning and expression methods. The receptor protein is useful in numerous diagnostic, prophylactic and therapeutic areas.
    Type: Application
    Filed: April 16, 2002
    Publication date: September 25, 2003
    Applicant: Philadelphia Health and Education Corporation
    Inventors: George Tuszynski, Taffy Williams
  • Retroinverso polypeptides that mimic or inhibit thrombospondin
    Publication number: 20030171298
    Abstract: The present invention relates generally to polypeptides that mimic or inhibit the biological activity of thrombospondin, and particularly to polypeptides in retroinverso form. The peptides. These polypeptides may be used biological and pharmaceutical applications such as: (a) inhibiting the invasive and metastatic activity of melanoma cells, (b) promoting and inhibiting cellular attachment to tissue culture flasks, (c) promoting wound healing, angiogenesis, and implant acceptance, (d) agents for anti-platelet aggregation, (e) agents for antimalarial activity, and (f) diagnostic reagents in different therapeutic applications, as well as other related areas.
    Type: Application
    Filed: October 3, 2001
    Publication date: September 11, 2003
    Applicant: INKINE PHARMACEUTICALS MCP HAHNEMANN
    Inventors: Taffy Williams, George Tuszynski, Paul Actor
  • Compositions for treating chemotherapy-resistant tumor cells and targeted chemotherapy compositions
    Patent number: 6380161
    Abstract: The present invention provides methods and compositions for treating cancer and chemotherapy-resistant cancers comprising a chemotherapeutic agent conjugated to or coadministered with a peptide.
    Type: Grant
    Filed: June 20, 2000
    Date of Patent: April 30, 2002
    Assignees: Inkine Pharmaceutical Company, Inc., Philadelphia Health and Education Corporation
    Inventors: Taffy Williams, George Tuszynski, Paul Actor
  • Retroinverso polypeptides that mimic or inhibit thrombospondin activity
    Patent number: 6339062
    Abstract: The present invention relates generally to polypeptides that mimic or inhibit the biological activity of thrombospondin, and particularly to polypeptides in retroinverso form. These polypeptides may be used for their biological and pharmaceutical applications such as: (a) inhibiting the invasive and metastatic activity of melanoma cells, (b) promoting and inhibiting cellular attachment to tissue culture flacks, (c) promoting wound healing, angiogenesis, and implant acceptance, (d) agents for anti-platelet aggregation, (e) agents for antimalarial activity, and (f) diagnostic reagents in different therapeutic applications, as well as other related areas.
    Type: Grant
    Filed: November 23, 1998
    Date of Patent: January 15, 2002
    Assignee: Inkine Pharmaceutical Company, Inc.
    Inventors: Taffy Williams, George Tuszynski, Paul Actor
  • Peptide fragments and analogs of thrombospondin and methods of use
    Patent number: 5190918
    Abstract: Compounds and compositions comprising fragments and synthetic analogs of human thrombospondin are provided together with methods for their use as thrombospondin-like agents.
    Type: Grant
    Filed: February 22, 1990
    Date of Patent: March 2, 1993
    Assignees: W. R. Grace & Co.-Conn., The Medical College of Pennsylvania
    Inventors: Alan H. Deutch, George Tuszynski
  • Use of thrombospondin to promote wound healing
    Patent number: 5155038
    Abstract: Pharmaceutical compositions and dressings useful in wound healing are provided. The pharmaceutical compositions comprise thrombospondin as the active ingredient.
    Type: Grant
    Filed: February 22, 1990
    Date of Patent: October 13, 1992
    Assignees: W. R. Grace & Co.-Conn., Medical College of Pennsylvania
    Inventors: Jacob Eyal, George Tuszynski