Abstract: An injectable nanoparticular formulation and method of use thereof for treating non-compressible hemorrhage or internal bleeding has been developed. The formulation includes two interactive components, one a targeting nanoparticle with a polypeptide sequence that binds to a cell present at a site of injury, and the other a crosslinking nanoparticle with a bioorthogonal click-crosslinking group.

Abstract: A system and method for coordinated and controlled abdominal gas insufflation includes clamp configured to engage an abdominal wall. A needle advancement control is configured to receive a needle and advance the needle toward the clamp to extend into a portion of the abdomen. A feedback device is configured to monitor the needle as it is advanced into the portion of the abdomen of the subject and provide feedback indicating that the needle has pierced the portion the abdomen.

Abstract: A system and method for coordinated and controlled abdominal gas insufflation includes clamp configured to engage an abdominal wall. A needle advancement control is configured to receive a needle and advance the needle toward the clamp to extend into a portion of the abdomen. A feedback device is configured to monitor the needle as it is advanced into the portion of the abdomen of the subject and provide feedback indicating that the needle has pierced the portion the abdomen.

Abstract: Exemplary systems and methods can be provided for providing information associated with tissue. For example, it is possible to illuminate the tissue with at least one electromagnetic radiation which is a coherent light and/or a partially coherent light. The electromagnetic radiation reflected from the tissue can be received and speckle patterns may be formed associated with the electromagnetic radiation. In addition, changes can be analyzed in the speckle patterns at time intervals sufficient to measure motion of or within a fascial compartment of the tissue. For example, it is also possible that the electromagnetic radiation is an interfered radiation from a sample and a reference. Further, the speckle patterns can be measured at different depths within the sample by moving the reference.

Abstract: Exemplary apparatus and process can be provided for determining at least one characteristic of an anatomical structure. For example, it is possible to generate an acoustic wave in the anatomical structure using an opto-accoustic arrangement It is then possible to detect the acoustic wave and determine whether at least one blood pool is present at or in the anatomical structure as a function of at least one property of the acoustic wave. Further, it is possible to forward at least one first electro-magnetic radiation to at least one tissue of the anatomical structure, detect at least one second electro-magnetic radiation provided from the at least one tissue based on a motion of or within the at least one tissue to generate detection data, and determine the at least one characteristic of the at least one portion based on the detection data.