Abstract: An implantable medical lead may include an electrode at a distal portion of the lead that is configured to monitor or provide therapy to a target site. The lead may include a visible indicator that is visible to the naked eye of a clinician at a medial portion of the lead that is configured to indicate when the electrodes of the lead are longitudinally and radially aligned properly to monitor or treat the target site. A clinician may insert the lead into the patient using an introducer sheath inserted to a predetermined depth into the patient and subsequently aligning the distal portion of the lead by orienting the indicator at an entry port of the introducer sheath.

Abstract: Disclosed herein is a method of inducing an immunological response in a subject which comprises administering an immunogenic amount of a purified fusion protein comprising all or part of F1 antigen of Yersinia pestis fused to the amino terminus of all of V antigen of Yersinia pestis, Yersinia enterocolitica, or Yersinia pseudotuberculosis to the subject.

Abstract: Disclosed herein is a composition comprising a purified fusion protein comprising all or part of F1 antigen of Yersinia pestis fused to the amino terminus of all of V antigen of Yersinia pestis, Yersinia enterocolitica, or Yersinia pseudotuberculosis that is isolated from its expression vector.

Abstract: Disclosed herein is a method of inducing an immunological response in a subject which comprises administering an immunogenic amount of a purified fusion protein comprising all or part of F1 antigen of Yersinia pestis fused to the amino terminus of all of V antigen of Yersinia pestis, Yersinia enterocolitica, or Yersinia pseudotuberculosis to the subject.

Abstract: Disclosed herein is a composition comprising a purified fusion protein comprising all or part of F1 antigen of Yersinia pestis fused to the amino terminus of all of V antigen of Yersinia pestis, Yersinia enterocolitica, or Yersinia pseudotuberculosis that is isolated from its expression vector.

Abstract: A recombinant vaccine is described which is composed of one recombinant protein comprising F1 and V antigen of Yersinia pestis. This vaccine protects experimental mice against pneumonic as well as bubonic plague produced by either F1+ or F1? strains of Y. pestis and may provide the basis for an improved human plague vaccine.

Abstract: An improved small animal restraint device is provided which enables an inidual to conduct ocular examinations of a small animal. The device minimizes manipulation of the eyes of the animal and eliminates recovery time associated with anesthetics, while also reducing examination time. The restraint device comprises a cylinder having a longitudinal slot in the wall thereof. A conical member which is attached to one end of the cylinder includes a pair of eye openings in the upper wall thereof and a nose opening at the apex thereof. A plunger placed in the cylinder at the other end thereof assists in holding the animal in place. A set screw, which extends through the slot in the wall of the cylinder, secures the plunger in place.

Abstract: Different products are hermetically sealed in separate but integrally adjoining packages to form package pairs or what might be called "dual" packages. All of the packages are made from two continuous sheets of plastic packaging material, and the separate packages of each pair are differentially-conditioned by differential evacuation and/or gassing to different pressure levels. A continuous series of filled side-by-side containers formed from one sheet of packaging material is conveyed in two parallel rows into a sealing region where a cover sheet is laid over the containers to form packages. A group of the packages is stopped in the sealing region, and are clamped and partially sealed around the peripheries of the individual packages. The individual side-by-side units of the package pairs are differentially conditioned as to vacuum pressure or gas pressure or composition through aligned openings between adjacent containers in each of the parallel rows.

Abstract: A method and apparatus are provided for packaging products between first and second plastic components sealed by using a hot melt adhesive applied by a dispensing applicator in one of several serially arranged stations of a packaging operation. The first plastic component is supported for indexing movement on a transport and moved under a hot melt applicator which is continuously driven in a predetermined path of travel which traverses the entire periphery of the product-loaded first plastic component. The first plastic component is stopped under the applicator for a predetermined dwell time during which the applicator dispenses the hot melt adhesive, then advanced to a position where the second plastic component is applied to form a filled package which is the evacuated and sealed. Apparatus is provided for preventing dripping or stringing of the hot melt adhesives.

Abstract: Different products are hermetically sealed in separate but integrally adjoining packages to form package pairs or what might be called "dual" packages. All of the packages are made from two continuous sheets of plastic packaging material, and the separate packages of each pair are differentially-conditioned by differential evacuation and/or gassing to different pressure levels. A continuous series of filled side-by-side containers formed from one sheet of packaging material is conveyed in two parallel rows into a sealing region where a cover sheet is laid over the containers to form packages. A group of the packages is stopped in the sealing region, and are clamped and partially sealed around the peripheries of the individual packages. The individual side-by-side units of the package pairs are differentially conditioned as to vacuum pressure or gas pressure or composition through aligned openings between adjacent containers in each of the parallel rows.

Abstract: A sealed package for pressurizing the contents of dispensing containers. The package contains chemicals which react to develop gas pressure to expand the package when in the dispensing container. A series of sequentially rupturable pockets add further increments of internal pressure as dispensing proceeds. These pockets, and additional pockets containing chemicals for initiating package pressurization, are formed in an outer film heat-sealed to a second outer film to define the package. The rupturable pockets are covered with a tape to maintain the chemicals isolated until rupture is effected by progressive lift-off of the tape as the package expands.

Abstract: A racket, especially for tennis and squash, has a strung head portion defined by a rigid frame of novel cross-sectional configuration. The frame has an imperforate wall extending around the greater part of the racket head, and integral with the wall a rigid section which is perforated at intervals to receive the stringing and which is formed as an elongate hollow protuberance projecting at least partially inwardly of the wall towards the center of the racket head. The main section of the frame is preferably a closed section, which may be internally divided into a plurality of discrete cells. The protuberant hollow section may be substantially circular in cross-section or generally rectangular in cross-section for example.

Abstract: A metallized hair roller for use in curling hair by wrapping strands of hair around the outer surface of the roller, securing the hair on the roller with a magnetic holder, clip or similar device and applying heat from an external heat source to the inner surface of the hair roller. The hair roller has an elongated hollow cylindrical plastic body which is encased in a composite metal coating of electrolytic metals creating a thermal energy cell.