Abstract: The invention provides a truck wheel containment frame, for enclosing and containing disengaged wheels of a vehicle within an interior of the frame. The frame includes support posts extending from the truck body and disposed laterally outward of the wheels. Containment bars or sheet metal span between each adjacent post for containing a disengaged wheel within the interior of the frame bounded the containment bars, the vehicular body and a roadway surface. The containment bars are disposed above the roadway a distance less than the thickness of a disengaged wheel. Releasable fasteners releasably connect the containment bars to the support posts. Preferably the truck wheel containment frame includes sensors for sensing the presence of a disengaged truck wheel within the interior of the frame. The invention may be applied to any type of truck such as a truck trailer combination multi-trailer assemblies, cement trucks, dump truck, liquid transport trailers and others.