Abstract: A method is provided for reducing an immune response to an allergen or antigenic determinant thereof in a mammal by administering a modulator of the Notch signalling pathway.

Abstract: Conjugates comprising a plurality of modulators of the Notch signalling pathway chemically bound to a support structure are described. The conjugates are useful for modulation of the Notch signalling pathway and treatment of associated conditions.

Abstract: A method is disclosed for therapeutic modulation of Notch signalling by administering a construct comprising a multiplicity of bond, linked or immobilised modulators of Notch signalling.

Abstract: A method for detecting modulators of Notch signalling is described. The method includes the step of monitoring Notch signalling in a cell of the immune system in the presence of a candidate modulator.

Abstract: Disclosed is a personalized, network-based, distributed learning system. The system allows for the dynamic creation of teaching materials personally tailored for the needs of the individual striving to learn the material. The system additionally allows for learning assessment of the student's comprehension of the course material, and dynamic creation of additional course material representing a portion of the course material not comprehended by the student. Additionally disclosed are methods for caching course content and developing a course curriculum for educating a student about the course material.

Abstract: A cushion element for use in the wheelchair. The cushion element includes a generally rectangular body in plane having a front edge, a pair of opposed side edges and a rear edge. The cushion element is sized and shaped to be placed on a seat support of a wheelchair. The cushion element includes at least one collapsible support located toward the front edge of the element. The collapsible support is characterized by being more easily compressed towards the front edge and less easily compressed towards the rear edge. Thereby, under compression, the collapsible support forms a wedge shaped section in cross-section beneath a wheelchair occupant's legs. In this manner, the person is permitted to reach their foot down to the ground without the formation of a pressure point at the front edge of the seat cushion.