Patents by Inventor George Wisely

George Wisely has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Car ligand-binding domain polypeptide co-crystallized with a ligand, and methods of designing ligands that modulate car activity
    Publication number: 20070003976
    Abstract: The present invention provides a crystalline form of a substantially pure constitutive androstane receptor (CAR) polypeptide. Also provided is a crystalline form of a substantially pure constitutive androstane receptor (CAR) polypeptide in complex with a ligand. Also provided are methods for generating the crystalline forms of the present invention and methods for identifying and designing CAR ligands and modulators. Also provided are scalable three-dimensional configurations of points and computer readable storage media containing digitally encoded structural data.
    Type: Application
    Filed: July 16, 2004
    Publication date: January 4, 2007
    Applicant: SMITHKLINE BEECHAM CORPORATION
    Inventors: Jon Collins, Millard Lambert, George Wisely, Xiaoyun Xu
  • Crystallized hnf4 gamma ligand binding domain polypeptide and screening methods employing same
    Publication number: 20050131209
    Abstract: A solved three-dimensional crystal structure of an HNF4g ligand binding domain polypeptide is disclosed, along with a crystal form of the HNF4g ligand binding domain. Methods of designing modulators of the biological activity of HNF4g, and other HNF4 ligand binding domain polypeptides are also disclosed.
    Type: Application
    Filed: January 31, 2002
    Publication date: June 16, 2005
    Inventors: Roderick Davis, Robert Johnson, Aaren Miller, James Way, Shawn Williams, Timothy Willson, George Wisely, Ann Kontz