Abstract: The present application provides tumor microenvironment acidity activated anti-CD3 constructs that bind to CD3 (e.g., anti-CD3 monoclonal and multispecific antibodies), nucleic acid molecules encoding an amino acid sequence of the anti-CD3, vectors comprising the nucleic acid molecules, host cells containing the vectors, methods of preparing the anti-CD3 construct, pharmaceutical compositions containing the anti-CD3 construct, and methods of using the anti-CD3 construct or compositions.

Abstract: The present application provides tumor microenvironment acidity activated anti-CD3 constructs that bind to CD3 (e.g., anti-CD3 monoclonal and multispecific antibodies), nucleic acid molecules encoding an amino acid sequence of the anti-CD3, vectors comprising the nucleic acid molecules, host cells containing the vectors, methods of preparing the anti-CD3 construct, pharmaceutical compositions containing the anti-CD3 construct, and methods of using the anti-CD3 construct or compositions.

Abstract: The present invention relates to compositions comprising the compound niraparib, in particular certain solid forms of niraparib.

Abstract: Provided are microfluidic systems and methods for detecting and sorting of droplets comprising heterogeneous particulate objects such as single cells and non-cell particles, including a variety of eukaryotic and bacterial cells, for a variety of bioassay applications. The systems and methods described herein, when implemented in whole or in part, will make relevant microfluidic based tools available for a variety of applications in biotechnology including antibody discovery, immuno-therapeutic discovery, high-throughput single cell analysis, target-specific compound screening, and synthetic biology screening.

Abstract: A lubricator assembly for servicing a tubular member includes a mounting base, a lubricant housing movably coupled to the mounting base and configured to receive lubricant from a lubricant source, a guide pin slidably disposed in the lubricant housing, a first seal positioned between the guide pin and the lubricant housing and a second seal positioned between the guide pin and the lubricant housing, and a first chamber extending between the first seal and the second seal, wherein the guide pin is configured to direct lubricant disposed in the first chamber against the tubular member in response to the tubular member engaging the guide pin.

Abstract: The present invention relates to compositions comprising the compound niraparib, in particular certain solid forms of niraparib.

Abstract: Disclosed herein are methods and processes of preparing niraparib and pharmaceutically acceptable salts thereof, and intermediates and their salts useful for the synthesis of niraparib.

Abstract: A key structure and an assembly method thereof are provided. The key structure includes a base plate, a switch, two fixing bases, two movable members and a keycap. The base plate includes upper and bottom surfaces, and has a first accommodation hole and two second accommodation holes. The switch is disposed on the base plate through the first accommodation hole. The two fixing bases are disposed on the base plate respectively through the two second accommodation holes. Each fixing base has a guiding channel. The two movable members are disposed in the two guiding channels. The keycap is disposed on the switch and the two movable members. Each fixing base includes a first portion protruded from the upper surface and a second portion protruded from the bottom surface. The vertical projection area of the first portion is not greater than the vertical projection area of the second portion.

Abstract: A multi-container system apparatus comprising at least two independent containers, each container of said at least two containers for containing at least one component of the final formulation of a medium; a connector; a connecting tubing line connected to the connector; at least two output tubing lines, the first and second output tubing lines of said at least two output tubing lines connecting the first and second containers of said at least two containers, respectively, to the connecting tubing line.

Abstract: Disclosed herein are methods and processes of preparing niraparib and pharmaceutically acceptable salts thereof, and intermediates and their salts useful for the synthesis of niraparib.

Abstract: A lubricator assembly for servicing a tubular member includes a mounting base, a lubricant housing movably coupled to the mounting base and configured to receive lubricant from a lubricant source, a guide pin slidably disposed in the lubricant housing, a first seal positioned between the guide pin and the lubricant housing and a second seal positioned between the guide pin and the lubricant housing, and a first chamber extending between the first seal and the second seal, wherein the guide pin is configured to direct lubricant disposed in the first chamber against the tubular member in response to the tubular member engaging the guide pin.

Abstract: The present invention relates to compositions comprising the compound niraparib, in particular certain solid forms of niraparib.

Abstract: Novel salts of niraparib are provided. Also provided are pharmaceutical compositions comprising those salts, as well as methods and uses pertaining to the same.

Abstract: Crystalline niraparib freebase is provided. Also provided are pharmaceutical compositions comprising crystalline niraparib freebase, and methods and uses pertaining to the same.

Abstract: Disclosed herein are methods and processes of preparing niraparib and pharmaceutically acceptable salts thereof, and intermediates and their salts useful for the synthesis of niraparib.

Abstract: The present invention relates to compositions comprising the compound niraparib, in particular certain solid forms of niraparib.

Abstract: The present invention relates to pharmaceutical capsule compositions comprising the compound niraparib as an active pharmaceutical ingredient, suitable for oral administration as well as to methods for their preparation. Also described herein are capsule formulations containing niraparib formed by the disclosed methods, and therapeutic uses of such capsule formulations for treating various disorders and conditions. The niraparib is distributed with substantial uniformity throughout a pharmaceutically acceptable carrier of the capsule formulations and exhibit good long-term stability and dissolution properties.

Abstract: The present invention relates to compositions comprising the compound niraparib, in particular certain solid forms of niraparib.

Abstract: A key structure and an assembly method thereof are provided. The key structure includes a base plate, a switch, two fixing bases, two movable members and a keycap. The base plate includes upper and bottom surfaces, and has a first accommodation hole and two second accommodation holes. The switch is disposed on the base plate through the first accommodation hole. The two fixing bases are disposed on the base plate respectively through the two second accommodation holes. Each fixing base has a guiding channel. The two movable members are disposed in the two guiding channels. The keycap is disposed on the switch and the two movable members. Each fixing base includes a first portion protruded from the upper surface and a second portion protruded from the bottom surface. The vertical projection area of the first portion is not greater than the vertical projection area of the second portion.

Abstract: Disclosed herein are methods and processes of preparing niraparib and pharmaceutically acceptable salts thereof, and intermediates and their salts useful for the synthesis of niraparib.