Patents by Inventor George Zhang

George Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11562400
    Abstract: A method includes training a plurality of different types of machine learning models using a training dataset to produce a set of trained machine learning models and determining a lift of each trained machine learning model in the set of trained machine learning models using a validation dataset. The method also includes selecting a trained machine learning model from the set of trained machine learning models that has a highest lift of the set of trained machine learning models and predicting a likelihood that a person will perform an action by applying the selected trained machine learning model to data about the person.
    Type: Grant
    Filed: September 23, 2021
    Date of Patent: January 24, 2023
    Assignee: International Business Machines Corporation
    Inventors: Jing Xu, Si Er Han, Xue Ying Zhang, Steven George Barbee, Ji Hui Yang
  • Publication number: 20220411402
    Abstract: Provided are 4?-arylmethoxy isoindoline compounds, and pharmaceutically acceptable salts, solvates, clathrates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.
    Type: Application
    Filed: July 18, 2022
    Publication date: December 29, 2022
    Inventors: Hon-Wah Man, Roger Shen-Chu Chen, George W. Muller, Alexander L. Ruchelman, Ehab M. Khalil, Weihong Zhang
  • Publication number: 20220411424
    Abstract: The present disclosure relates to complexes comprising caffeine and tannic acid as well as emulsions and beverages comprising these complexes which slow the release of the caffeine. Also described are methods of preparing the complexes and emulsions and beverages comprising caffeine-tannic acid complexes.
    Type: Application
    Filed: June 17, 2022
    Publication date: December 29, 2022
    Inventors: Yu WANG, DaSom NO, Yuan FANG, Nelson TRUSLER, Damian BROWNE, George MEYER, Xin ZHAO, Meng TIAN, Shiyi ZHANG
  • Publication number: 20220401449
    Abstract: The present disclosure relates to colloids comprising caffeine-tannic acid complexes which slow the release of the caffeine. Also described are methods of preparing the colloids and beverages comprising colloids comprising caffeine-tannic acid complexes.
    Type: Application
    Filed: June 17, 2022
    Publication date: December 22, 2022
    Inventors: Yu WANG, DaSom NO, Yuan FANG, Nelson TRUSLER, Damian BROWNE, Xin ZHAO, Meng TIAN, Shiyi ZHANG, George MEYER, Rohil BHATNAGAR
  • Publication number: 20220379443
    Abstract: A screwdriver includes a shank, a ratchet assembly, and a handle. The shank includes a shank extender that in an extended position lengthens the shank and in a retracted position is stored within the handle of the screwdriver. The ratchet assembly includes a knob and is configured to drive in the same direction the knob is turned. The screwdriver includes a locking mechanism to prevent unwanted movement of the shank between the extended and retracted positions. The handle of the screwdriver includes a storage space to hold alternative screwdriver bits and a stabilizing component to decrease movement of the handle when the storage portion is in an extended or open position. In a closed position the handle surrounds the alternate bits and in an open position the alternate bits are exposed.
    Type: Application
    Filed: May 27, 2022
    Publication date: December 1, 2022
    Inventors: Joshua D. Schneider, Colin J. Roberts, Scott M. Hangartner, George Barton, Cheng Zhang Li, Kai-Wen Cheng
  • Publication number: 20220363760
    Abstract: The present disclosure provides methods of identifying a subject suitable for an immunooncology (I-O) therapy comprising measuring the expression of one or more genes of a pantumor inflammation gene panel. In some aspects, the method further comprises administering an I-O therapy to the subject. In some aspects, the I-O therapy comprises administering an anti-PD-1 antibody or antigen-binding portion thereof or an anti-PD-L1 antibody or antigen-binding portion thereof to the subject.
    Type: Application
    Filed: May 29, 2020
    Publication date: November 17, 2022
    Applicant: Bristol-Myers Squibb Company
    Inventors: Peter M. SZABO, Lan ZHANG, Keyur H. DESAI, Neeraj ADYA, Zhenhao QI, Kim ZERBA, Scott Adams ELY, Saumya PANT, George A. GREEN
  • Publication number: 20220332864
    Abstract: Provided herein are methods of polymerizing ?-olefin monomer with a catalyst and hydrogen in a slurry to produce low molecular weight polyolefins. Hydrogen is vented from the low molecular weight polyolefins and then the low molecular weight polyolefins are further polymerized in a gas phase to produce a polyolefin having a molecular weight distribution of between 4.0 and 30 and a flexural modulus between 1500 mPa and 2500 mPa.
    Type: Application
    Filed: August 14, 2020
    Publication date: October 20, 2022
    Applicant: EXXONMOBIL CHEMICAL PATENTS INC.
    Inventors: Xiaodan ZHANG, Christopher G. BAUCH, Lubin LUO, Jeffrey L. BRINEN, George J. PEHLERT, Todd S. EDWARDS, Sung A. KIM
  • Publication number: 20220324812
    Abstract: The present disclosure relates to compounds that act as inhibitors of NLRP3 inflammasomes; pharmaceutical compositions comprising the compounds; and methods of treating disorders associated with inflammation and inflammaging, including hearing loss and other diseases associated with aging.
    Type: Application
    Filed: March 23, 2022
    Publication date: October 13, 2022
    Inventors: George HARTMAN, XU HE, JIA DU, LIFANG ZHANG, Paul Humphries, Kevin Edward Leif Wilhelmsen
  • Publication number: 20220292401
    Abstract: A computer-implemented method, system and computer program product for improving prediction accuracy in machine learning techniques. A teacher model is constructed, where the teacher model generates a weight for each data case. The current student model is then trained using training data and the weights generated by the teacher model. After training the current student model, the current student model generates state features, which are used by the teacher model to generate new weights. A candidate student model is then trained using training data and these new weights. A reward is generated by comparing the current student model with the candidate student model using training and testing data, which is used to update the teacher model if a stopping rule has not been satisfied. Upon a stopping rule being satisfied, the weights generated by the teacher model are deemed to be the “optimal” weights which are returned to the user.
    Type: Application
    Filed: May 27, 2022
    Publication date: September 15, 2022
    Inventors: Jing Xu, Si Er Han, Steven George Barbee, Xue Ying Zhang, Ji Hui Yang
  • Patent number: 11443235
    Abstract: A computer-implemented method, system and computer program product for improving prediction accuracy in machine learning techniques. A teacher model is constructed, where the teacher model generates a weight for each data case. The current student model is then trained using training data and the weights generated by the teacher model. After training the current student model, the current student model generates state features, which are used by the teacher model to generate new weights. A candidate student model is then trained using training data and these new weights. A reward is generated by comparing the current student model with the candidate student model using training and testing data, which is used to update the teacher model if a stopping rule has not been satisfied. Upon a stopping rule being satisfied, the weights generated by the teacher model are deemed to be the “optimal” weights which are returned to the user.
    Type: Grant
    Filed: November 14, 2019
    Date of Patent: September 13, 2022
    Assignee: International Business Machines Corporation
    Inventors: Jing Xu, Si Er Han, Steven George Barbee, Xue Ying Zhang, Ji Hui Yang
  • Patent number: 11434262
    Abstract: Provided herein are compositions, kits and methods useful in the construction of designer transcription activator-like effector (dTALE) polypeptides.
    Type: Grant
    Filed: October 26, 2016
    Date of Patent: September 6, 2022
    Assignee: President and Fellows of Harvard College
    Inventors: Feng Zhang, Le Cong, Sriram Kosuri, George M. Church
  • Publication number: 20220259669
    Abstract: The present disclosure provides methods of identifying a subject suitable for an immunooncology (I-O) therapy comprising measuring the expression of one or more of STAT1, IFN?, NECTIN2, and CSFIR. In some aspects, the I-O therapy comprises administering an anti-PD-1 antibody or antigen-binding portion thereof or an anti-PD-L1 antibody or antigen-binding portion thereof to the subject.
    Type: Application
    Filed: May 29, 2020
    Publication date: August 18, 2022
    Applicant: Bristol-Myers Squibb Company
    Inventors: Peter M. SZABO, Lan ZHANG, Keyur H. DESAI, Neeraj ADYA, Zhenhao QI, Alex GREENFIELD, George C. LEE, Scott Adams ELY, Saumya PANT, George A. GREEN
  • Patent number: 11414399
    Abstract: Provided are 4?-arylmethoxy isoindoline compounds, and pharmaceutically acceptable salts, solvates, clathrates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.
    Type: Grant
    Filed: March 31, 2020
    Date of Patent: August 16, 2022
    Assignee: CELGENE CORPORATION
    Inventors: Hon-Wah Man, Roger Shen-Chu Chen, George W. Muller, Alexander L. Ruchelman, Ehab M. Khalil, Weihong Zhang
  • Publication number: 20220233691
    Abstract: The present disclosure provides methods of identifying a subject suitable for an immuno-oncology (I-O) therapy comprising measuring the expression of one or more of STAT1, IFN?, NECTIN2, and CSF1R. In some aspects, the I-O therapy comprises administering an anti-PD-1 antibody or antigen-binding portion thereof or an anti-PD-L1 antibody or antigen-binding portion thereof to the subject.
    Type: Application
    Filed: May 29, 2020
    Publication date: July 28, 2022
    Applicant: Bristol-Myers Squibb Company
    Inventors: Peter SZABO, Lan ZHANG, Keyur H. DESAI, Neeraj ADYA, Zhenhao QI, Alex GREENFIELD, George C. LEE, Scott Adams ELY, Saumya PANT, George A. GREEN
  • Publication number: 20210401798
    Abstract: The invention relates to (S)-6-((1 R,2E,4E,8E,10S)-11-(4-fluorophenoxy)-1,10-dihydroxyundeca-2,4,8-trien-6-yn-1-yl)-1,4-dioxan-2-one (compound (1)), which is a lactone-containing analog of lipoxin A4 (LXA4). In particular, the invention features pharmaceutical compositions including compound (1) and the use of compound (1) for the treatment of a disorder (e.g., a fibrotic disorder or an inflammatory disorder, such as an autoimmune disorder) in a subject in need thereof.
    Type: Application
    Filed: October 23, 2019
    Publication date: December 30, 2021
    Applicants: The Brigham and Women's Hospital, Inc., Corbus Pharmaceuticals, Inc., Corbus Pharmaceuticals, Inc.
    Inventors: Nan CHIANG, Sheldon N. CRANE, Thomas JENNEQUIN, Valdas JURKAUSKAS, Clifton D. LEIGH, Kristos Adrian MOSHOS, Charles N. Serhan, Mark A. Tepper, Yuhua George Zhang
  • Publication number: 20210284621
    Abstract: The invention relates to cannabinoid compounds, pharmaceutical compositions including one or more cannabinoid compounds, and the use of pharmaceutical compositions including one or more cannabinoid compounds for the treatment of a disease or condition (e.g., a fibrotic disease or an inflammatory disease) in a subject in need thereof.
    Type: Application
    Filed: May 31, 2019
    Publication date: September 16, 2021
    Inventors: Kristos Adrian MOSHOS, Clifton D. LEIGH, Yuhua George ZHANG, Mark TEPPER, Hongfeng DENG
  • Patent number: D920915
    Type: Grant
    Filed: April 13, 2020
    Date of Patent: June 1, 2021
    Assignee: Eaton Intelligent Power Limited
    Inventors: Alex Zhuang, George Zhang, Erik Jeffrey Gouhl, Darron Kirby Lacey, Tom Xiong
  • Patent number: D929340
    Type: Grant
    Filed: April 27, 2021
    Date of Patent: August 31, 2021
    Assignee: Eaton Intelligent Power Limited
    Inventors: Alex Zhuang, George Zhang, Erik Jeffrey Gouhl, Darron Kirby Lacey, Tom Xiong
  • Patent number: D947798
    Type: Grant
    Filed: April 27, 2021
    Date of Patent: April 5, 2022
    Assignee: Eaton Intelligent Power Limited
    Inventors: Alex Zhuang, George Zhang, Erik Jeffrey Gouhl, Harry Zhang, Andrew Yang, Darron Kirby Lacey, Tom Xiong
  • Patent number: D964942
    Type: Grant
    Filed: September 9, 2020
    Date of Patent: September 27, 2022
    Assignee: Eaton Intelligent Power Limited
    Inventors: George Zhang, Alex Zhuang, Dai Vo