Patents by Inventor Georges Bismuth

Georges Bismuth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTI-NEUROPILIN-1 AND ANTI-PROGRAMMED CELL DEATH-1 COMBINATION THERAPY FOR TREATING CANCER
    Publication number: 20220023342
    Abstract: The present invention relates to the combined use of a neuropilin-1 (Nrp-1) neutralizing agent and of a programmed cell death-1 (PD-1) neutralizing agent for killing cancer cells, typically for treating cancer, as well as to corresponding pharmaceutical compositions and kits, and to corresponding diagnostic and therapeutic methods. The invention further relates to in vitro, ex vivo and in vivo methods for detecting CD8+ TILs capable of recognizing cancer cells, for predicting the response of a subject to anti-PD-1 treatment of cancer, and for identifying a subject who responds therapeutically to a treatment of cancer with an antibody combination therapy comprising anti-Nrp-1 and anti-PD-1 antibodies.
    Type: Application
    Filed: December 2, 2019
    Publication date: January 27, 2022
    Inventors: FATHIA MAMI-CHOUAIB, MARINE LECLERC, GEORGES BISMUTH
  • Structural variants of mycolactones for use in modulating inflammation, immunity and pain
    Patent number: 9598393
    Abstract: The present invention is related to variants of mycolactones of formula (I), processes for the preparation thereof, pharmaceutical compositions thereof and their use in modulating inflammation, immunity and pain. Y—O—W (I), wherein Y and W are as defined in claim 1.
    Type: Grant
    Filed: November 16, 2012
    Date of Patent: March 21, 2017
    Assignee: Institut Pasteur
    Inventors: Caroline Demangel, Nicolas Blanchard, Georges Bismuth, Jacques Eustache, Virginie Casarotto, Anne-Caroline Chany, Laure Guenin-Mace
  • STRUCTURAL VARIANTS OF MYCOLACTONES FOR USE IN MODULATING INFLAMMATION, IMMUNITY AND PAIN
    Publication number: 20140329771
    Abstract: The present invention is related to variants of mycolactones of formula (I), processes for the preparation thereof, pharmaceutical compositions thereof and their use in modulating inflammation, immunity and pain. Y—O—W (I), wherein Y and W are as defined in claim 1.
    Type: Application
    Filed: November 16, 2012
    Publication date: November 6, 2014
    Inventors: Caroline Demangel, Nicolas Blanchard, Georges Bismuth, Jacques Eustache, Virginie Casarotto, Anne-Caroline Chany, Laure Guenin-Mace