Patents by Inventor Georges E. Lambelin

Georges E. Lambelin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4738979
    Abstract: A compound of the formula: ##STR1## wherein X.sup.1, X.sup.2, Y.sup.1 and Y.sup.2, whether or not identical are hydrogen, a halogen such as fluoro, chloro or bromo, linear or branched alkyl of 1 to 3 carbon atoms, linear or branched alkoxy of 1 to 3 carbon atoms, carboxy, alkoxy-carbonyl of 1 to 3 carbon atoms or phenyl;R.sup.1 is hydrogen, methyl or phenyl;R.sup.2 and R.sup.3, which may or may not be identical, are hydrogen, hydroxyl, linear or branched alkyl of 1 to 6 carbon atoms, or linear or branched alkoxy group of 1 to 4 carbon atoms;R.sup.1 and R.sup.2 may together form a carbon-carbon double bond; andR.sup.4 and R.sup.5 whether or not identical, are hydrogen, linear or branched alkyl or 1 to 3 carbon atoms.The compounds are useful as blocking agents of .alpha..sub.2 -adrenergic receptors.
    Type: Grant
    Filed: January 27, 1986
    Date of Patent: April 19, 1988
    Assignee: G. D. Searle & Co.
    Inventors: Piedad Calderon, Alexis A. Cordi, Claude L. Gillet, Hugo J. Gorissen, Georges E. Lambelin, Joseph L. Roba, Michel P. Snyers, William R. van Dorsser
  • Patent number: 4639468
    Abstract: A glycinamide derivative of the general formula I: ##STR1## wherein: R is a linear or ramified alkyl group C.sub.5 -C.sub.18, a linear or ramified alkenyl group C.sub.5, C.sub.6, C.sub.7, C.sub.8, C.sub.9, C.sub.10, C.sub.11, C.sub.12, C.sub.13, C.sub.14, C.sub.15, C.sub.16, C.sub.17 or C.sub.18, a linear or ramified alkynyl group C.sub.4 -C.sub.10, a linear or ramified acyl group C.sub.4 -C.sub.18, a linear or ramified alkyl group C.sub.1 -C.sub.10, substituted by a phenoxy group, by a hydroxy radical, by an acetoxy radical, by a carboxy radical, by a linear or ramified alkoxycarbonyl group C.sub.1 -C.sub.4, by a carbonyl radical, by a carboxaldehyde group, by an acetal or cetal group, by one or more phenyl groups, by one or more phenyl groups substituted by a halogen atom such as fluorine, chlorine or bromine,R.sub.1 represents hydrogen, a linear or ramified alkyl group C.sub.1, C.sub.2, C.sub.3, C.sub.4, C.sub.5, C.sub.6, C.sub.7, C.sub.8, C.sub.9 or C.sub.10, a linear or ramified acyl group C.sub.1 -C.
    Type: Grant
    Filed: August 23, 1985
    Date of Patent: January 27, 1987
    Assignee: Continental Pharma Inc.
    Inventors: Romeo Roncucci, Claude L. Gillet, Alexis H. Cordi, Mark A. Martens, Joseph L. Roba, Paul J. Niebes, Georges E. Lambelin, William R. Van Dorsser
  • Patent number: 4638070
    Abstract: This invention relates to heterocyclic amino-alcohol derivatives of the formula ##STR1## These compounds are useful as antihypertensives.
    Type: Grant
    Filed: June 30, 1980
    Date of Patent: January 20, 1987
    Assignee: Continental Pharma
    Inventors: Georges E. Lambelin, Romeo R. Roncucci, Joseph Roba, Claude L. Gillet
  • Patent number: 4562205
    Abstract: 2-Pentanoylaminoacetic acid and pharmaceutically suitable salts thereof are claimed for use as pharmaceuticals.The compounds are useful in producing an effect on the central nervous system, especially in the treatment of various forms of epilepsy, of disninesiae, of parkinsonism, of memory troubles, of psychic troubles and of cerebral anoxia.
    Type: Grant
    Filed: June 25, 1984
    Date of Patent: December 31, 1985
    Assignee: Continental Pharma Inc.
    Inventors: Robert G. Cavalier, Alexis A. Cordi, Claude L. Gillet, Philippe M. Janssens de Varebeke, Paul J. Niebes, Joseph L. Roba, William R. Van Dorsser, Georges E. Lambelin, Michel R. Franz
  • Patent number: 4534911
    Abstract: Method for the preparation of micronized p-butoxyphenylacetylhydroxamic acid, comprising dissolving the p-butoxyphenylacetylhydroxamic acid in a basic solution of salifying agent and then precipitating it in an acid solution in the presence of a surface-active agent.
    Type: Grant
    Filed: December 7, 1983
    Date of Patent: August 13, 1985
    Assignee: Continental Pharma, Inc.
    Inventors: Michel R. Franz, Andreas B. Vincze, Georges E. Lambelin, Alain V. Polat
  • Patent number: 4507314
    Abstract: Drug for treating affections provoked by a too high histamine level in the body, for treating affections of the gastroduodenal mucosa and allergic affections, comprising the reaction product of (+)-catechin with at least one basic amino-acid, which is more particularly selected from the group consisting of L-lysine, L-arginine and L-ornithine.
    Type: Grant
    Filed: July 20, 1983
    Date of Patent: March 26, 1985
    Assignee: Midit, Societe Fiduciaire
    Inventors: Paul J. Niebes, Daniel M. Matagne, Etienne P. Hanon, Joseph L. Roba, Georges E. Lambelin
  • Patent number: 4338330
    Abstract: A derivative of benzimidazole of the general formula I: ##STR1## wherein: R.sub.1 represents a linear or ramified alkyl radical C.sub.1,C.sub.2,C.sub.3,C.sub.4,C.sub.5,C.sub.6,C.sub.7,C.sub.8,C.sub.9,C. sub.10,C.sub.11,C.sub.12,C.sub.13,C.sub.14,C.sub.15, C.sub.16,C.sub.17 or C.sub.18, a cycloalkyl radical C.sub.3,C.sub.4,C.sub.5,C.sub.6,C.sub.7 or C.sub.8, a linear or ramified alkyl radical C.sub.1,C.sub.2,C.sub.3,C.sub.4 or C.sub.5 substituted by one or more radicals selected from the group comprising:phenyl, phenoxy, phenylthio, phenylsufinyl radicals;phenyl, phenoxy, phenylthio, phenylsulfinyl radicals substituted by one or more linear or ramified alkyl radicals C.sub.1,C.sub.2, C.sub.3 or C.sub.4, by one or more linear or ramified alkoxy radicals C.sub.1,C.sub.2, C.sub.3 or C.sub.4, by a methylenedioxy radical, for one or more halogen atoms, such as fluorine, chlorine or bromine;linear or ramified alkylcarboxamido groups C.sub.1,C.sub.2,C.sub.3,C.sub.4,C.sub.5 or C.sub.
    Type: Grant
    Filed: April 30, 1980
    Date of Patent: July 6, 1982
    Assignee: Continental Pharma
    Inventors: Claude L. Gillet, Joseph L. Roba, Michel Snyers, William R. Van Dorsser, Georges E. Lambelin
  • Patent number: 4268517
    Abstract: A pharmaceutical composition for treating degenerative diseases of the articular cartilage, in particular osteoarthritis and chondromalacia, and of the degenerative processes of the articular cartilage resulting from other diseases, such as rheumatoid arthritis, this composition containing (+) - catechin and/or one of the salts thereof as an active products, said composition being administered orally, rectally, intra-articularly, intravenously or topically.
    Type: Grant
    Filed: August 30, 1979
    Date of Patent: May 19, 1981
    Assignee: Continental Pharma
    Inventors: Paul J. Niebes, Andras B. Vincze, Joseph L. Roba, Georges E. Lambelin, Daniel M. Matagne, Etienne T. Hanon, Michel R. Franz
  • Patent number: 4228187
    Abstract: Amino-alcohols of the formula ##STR1## wherein R.sub.1 represents either a linear or branched chain alkyl radical having 1 to 4 carbon atoms, or a cycloalkyl radical having 5 or 6 carbon atoms; R.sub.2 represents a lower alkyl radical having 1 or 2 carbon atoms; R.sub.3 represents a linear or branched chain alkyl radical having 3 to 10 carbon atoms which radical is optionally substituted by phenyl; R.sub.4 represents hydrogen, or, together with R.sub.3 and the adjacent nitrogen atom, a heterocyclic nucleus of the piperidine type and the corresponding non-toxic salts of said amino-alcohols; preparation of the above and their use as antispasmodic, peripheral vasodilatory and anti-hypertensive agents and as an agent having a protective activity against anoxia of the myocardium.
    Type: Grant
    Filed: August 30, 1976
    Date of Patent: October 14, 1980
    Assignee: Continental Pharma
    Inventors: Georges E. Lambelin, Claude L. Gillet, Joseph L. Roba
  • Patent number: 3954871
    Abstract: The new amino-alcohols according to the invention are represented by the formula ##SPC1##Wherein: R.sub.1 represents a RS, RSO or RSO.sub.2 group in which R is a linear or branched alkyl group (C.sub.1 -C.sub.10), an acetyl radical or hydrogen; R.sub.2 and R.sub.3, which may be identical or different, represent a halogen atom or an alkyl (C.sub.1 -C.sub.3), amino, alkylamino (C.sub.1 -C.sub.4), acylamino, nitro, carboxy, carbalkoxy, trifluoromethyl, alkoxy (C.sub.1 -C.sub.4) or alkylthio (C.sub.1 -C.sub.4) radical; R.sub.4 represents hydrogen or a linear or branched alkyl radical containing 1 - 4 carbon atoms; R.sub.5 and R.sub.6, which may be identical or different, represent hydrogen, a substituted or not, linear or branched alkyl (C.sub.1 -C.sub.16) radical, a cycloalkyl (C.sub.5 -C.sub.6) radical, an alkynyl (C.sub.3 -C.sub.4) radical, an alkenyl (C.sub.3 -C.sub.4) radical or a heterocycle of the kind piperidine, morpholine, pyridine or pyridimine, R.sub.5 and R.sub.
    Type: Grant
    Filed: March 29, 1974
    Date of Patent: May 4, 1976
    Assignee: Continental Pharma
    Inventors: Nguyen Phuc Buu-Hoi, Georges E. Lambelin, Joseph L. Roba, Claude Gillet, Guy D. Jacques