Patents by Inventor Georges Thiry

Georges Thiry has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • VACCINE COMPOSITION
    Publication number: 20160175423
    Abstract: The present invention relates to an immuno-protective and non-toxic Gram-negative bleb vaccine suitable for paediatric use. Examples of the Gram-negative strains from which the blebs are made are N. meningitidis, M. catarrhalis and H. influenzae. The blebs of the invention are characterized by one or more genetic changes to the chromosome of the bacterium, including up-regulation of protective antigens, down-regulation of immunodominant non-protective antigens, and detoxification of the Lipid A moiety of LPS.
    Type: Application
    Filed: March 2, 2016
    Publication date: June 23, 2016
    Inventors: Francois-Xavier Jacques BERTHET, Wilfried LJ DALEMANS, Philippe DENOEL, Joelle THONNARD, Christiane FERON, Jan POOLMAN, Georges THIRY, Pierre VOET, Yves LOBET, Guy DEQUESNE
  • VACCINE COMPOSITION
    Publication number: 20140294935
    Abstract: The present invention relates to an immuno-protective and non-toxic Gram-negative bleb vaccine suitable for paediatric use. Examples of the Gram-negative strains from which the blebs are made are N. meningitidis, M. catarrhalis and H. influenzae. The blebs of the invention are improved by one or more genetic changes to the chromosome of the bacterium, including up-regulation of protective antigens, down-regulation of immunodominant non-protective antigens, and detoxification of the Lipid A moiety of LPS.
    Type: Application
    Filed: May 12, 2014
    Publication date: October 2, 2014
    Inventors: Francois-Xavier Jacques Berthet, Wilfried Dalemans, Philippe Denoel, Guy Dequesne, Christiane Feron, Yves Lobet, Jan Poolman, George Thiry, Joelle Thonnard, Pierre Voet
  • Homogeneous attenuated human rotavirus population
    Patent number: 7790179
    Abstract: The invention provides an attenuated rotavirus population comprising a single variant or substantially a single variant which is defined by a nucleotide sequence encoding at least one of the major viral proteins designated as VP4 and VP7. The invention particularly provides a rotavirus population designated as P43. The invention further provides a novel formulation for a rotavirus vaccine which is in the form of a quick dissolving tablet for immediate dissolution when placed on the tongue.
    Type: Grant
    Filed: August 22, 2007
    Date of Patent: September 7, 2010
    Assignee: GlaxoSmithKline Biologicals, SA
    Inventors: Brigitte Desiree Alberte Colau, Francoise Denamur, Isabelle Knott, Annick Poliszczak, Georges Thiry, Vincent Vande Velde
  • Immunogenic composition of a homogeneous live attenuated human rotavirus population
    Patent number: 7790180
    Abstract: The invention provides an attenuated rotavirus population comprising a single variant or substantially a single variant which is defined by a nucleotide sequence encoding at least one of the major viral proteins designated as VP4 and VP7. The invention particularly provides a rotavirus population designated as P43. The invention further provides a novel formulation for a rotavirus vaccine which is in the form of a quick dissolving tablet for immediate dissolution when placed on the tongue.
    Type: Grant
    Filed: October 19, 2007
    Date of Patent: September 7, 2010
    Assignee: Glaxosmithkline Biologicals SA
    Inventors: Brigitte Desiree Alberte Colau, Francoise Denamur, Isabelle Knott, Annick Poliszczak, Georges Thiry, Vincent Vande Velde
  • VACCINE
    Publication number: 20090130145
    Abstract: The invention provides an attenuated rotavirus population comprising a single variant or substantially a single variant which is defined by a nucleotide sequence encoding at least one of the major viral proteins designated as VP4 and VP7. The invention particularly provides a rotavirus population designated as P43. The invention further provides a novel formulation for a rotavirus vaccine which is in the form of a quick dissolving tablet for immediate dissolution when placed on the tongue.
    Type: Application
    Filed: August 22, 2007
    Publication date: May 21, 2009
    Inventors: Brigitte Desiree Alberte Colau, Francoise Denamur, Isabelle Knott, Annick Poliszczak, Georges Thiry, Vincent Vande Velde
  • VACCINES COMPRISING OUTER MEMBRANE VESICLES FROM GRAM NEGATIVE BACTERIA
    Publication number: 20090117147
    Abstract: The present invention relates to the field of vaccine formulation, particularly the field of novel adjuvant compositions comprising outer membrane vesicles (or blebs), and advantageous methods of detoxifying these compositions, and advantageous methods of use of such adjuvants.
    Type: Application
    Filed: December 3, 2007
    Publication date: May 7, 2009
    Inventors: Francois-Xavier Jacques BERTHET, Wilfried L J. Dalemans, Philippe Denoel, Guy Dequesne, Christiane Feron, Nathalie Garcon, Yves Lobet, Jan Poolman, Georges Thiry, Joelle Thonnard, Pierre Voet
  • Vaccine Composition
    Publication number: 20080233154
    Abstract: The present invention relates to an immuno-protective and non-toxic Gram-negative bleb vaccine suitable for paediatric use. Examples of the Gram-negative strains from which the blebs are made are N. meningitidis, M. catarrhalis and H. influenzae. The blebs of the invention are improved by one or more genetic changes to the chromosome of the bacterium, including up-regulation of protective antigens, down-regulation of immunodominant non-protective antigens, and detoxification of the Lipid A moiety of LPS.
    Type: Application
    Filed: August 25, 2006
    Publication date: September 25, 2008
    Inventors: Francois-Xavier Jacques Berthet, Wilfried Dalemans, Philippe Denoel, Guy Dequesne, Christiane Feron, Yves Lobet, Jan Poolman, Georges Thiry, Joelle Thonnard, Pierre Voet
  • VACCINE
    Publication number: 20080063662
    Abstract: The invention provides an attenuated rotavirus population comprising a single variant or substantially a single variant which is defined by a nucleotide sequence encoding at least one of the major viral proteins designated as VP4 and VP7. The invention particularly provides a rotavirus population designated as P43. The invention further provides a novel formulation for a rotavirus vaccine which is in the form of a quick dissolving tablet for immediate dissolution when placed on the tongue.
    Type: Application
    Filed: August 23, 2007
    Publication date: March 13, 2008
    Inventors: Brigitte Colau, Francoise Denamur, Isabelle Knott, Annick Poliszczak, Georges Thiry, Vincent Vande Velde
  • VACCINE
    Publication number: 20080057082
    Abstract: The invention provides an attenuated rotavirus population comprising a single variant or substantially a single variant which is defined by a nucleotide sequence encoding at least one of the major viral proteins designated as VP4 and VP7. The invention particularly provides a rotavirus population designated as P43. The invention further provides a novel formulation for a rotavirus vaccine which is in the form of a quick dissolving tablet for immediate dissolution when placed on the tongue.
    Type: Application
    Filed: October 19, 2007
    Publication date: March 6, 2008
    Inventors: Brigitte COLAU, Francoise Denamur, Isabelle Knott, Annick Poliszczak, Georges Thiry, Vincent Velde
  • Vaccine composition
    Publication number: 20060216307
    Abstract: The present invention relates to an immuno-protective and non-toxic Gram-negative bleb vaccine suitable for paediatric use. Examples of the Gram-negative strains from which the blebs are made are N. meningitidis, M. catarrhalis and H. influenzae. The blebs of the invention are improved by one or more genetic changes to the chromosome of the bacterium, including up-regulation of protective antigens, down-regulation of immunodominant non-protective antigens, and detoxification of the Lipid A moiety of LPS.
    Type: Application
    Filed: June 9, 2006
    Publication date: September 28, 2006
    Inventors: Francois-Xavier Berthet, Wilfried Dalemans, Philippe Denoel, Guy Dequesne, Christiane Feron, Yves Lobet, Jan Poolman, Georges Thiry, Joelle Thonnard, Pierre Voet
  • Vaccine composition
    Publication number: 20040126389
    Abstract: The present invention relates to the field of vaccine formulation, particularly the field of novel adjuvant compositions comprising outer membrane vesicles (or blebs), and advantageous methods of detoxifying these compositions, and advantageous methods of use of such adjuvants.
    Type: Application
    Filed: September 15, 2003
    Publication date: July 1, 2004
    Inventors: Francois-Xavier Jacques Berthet, Wilfried L J Dalemans, Philippe Denoel, Guy Dequesne, Chriatiane Feron, Nathalie Garcon, Yves Lobet, Jan Poolman, Georges Thiry, Joelle Thonnard, Pierre Voet